Circular RNA Rftn1 Promotes Cardiac Hypertrophy In Vitro and In Vivo by Sponging miRNA-1192 to Upregulate Tripartite Motif Protein 25 and 41 [0.03%]
环状RNA Rftn1通过海绵作用miRNA-1192上调三联体基序蛋白25和41促进心脏肥大
Guangcheng Liu,Haipeng Zhang,Jingdai Zhang et al.
Guangcheng Liu et al.
To verify the role of circular RNA circRftn1 in cardiac hypertrophy and elucidate its potential mechanism via the microRNA-1192-tripartite motif 25 and 41 (miR1192-TRIM25/TRIM41) axis. A mouse model of cardiac hypertrophy was established vi...
Centipede Polypeptide Affects the Inflammatory Reaction and Ferroptosis of Liver Cancer Cells Through the p53/TRAIL Pathway [0.03%]
马陆多肽通过p53/TRAIL信号通路影响肝癌细胞的炎症反应及铁死亡
Xingru Xing,Linzhu Lu,Zhen Huang et al.
Xingru Xing et al.
Various extracts from centipedes have therapeutic effects on liver cancer. This study aims to illustrate the impact and mechanism of centipede polypeptide (CP) on liver cancer. The suitable CP concentration and liver cancer cells were scree...
Repurposing Doxycycline to Overcome High-Glucose-Induced Mitochondrial Biogenesis-Mediated Chemoresistance in Colorectal Cancer Cells [0.03%]
二甲双胍联合多西环素通过靶向胶质瘤细胞线粒体自噬增强放射增敏作用
Chang-Han Wu,Ching-Wen Huang,Yen-Cheng Chen et al.
Chang-Han Wu et al.
Chemoresistance is a major contributor to treatment failure in most patients with cancer. Hyperglycaemia enhances chemoresistance in stage III colorectal cancer (CRC) patients, potentially through a mechanism involving c-Myc. Phospho-PGC-1...
Chengxin Chen,Mengle Peng,Shuhong Liang et al.
Chengxin Chen et al.
Copper ions serve as multifunctional signalling molecules that are integral to various cellular processes in vivo, including cell proliferation, apoptosis and migration. The storage, transport and homeostatic regulation of intracellular cop...
Circulating Erythrocyte- and Endothelial-Derived Microvesicles as Biomarkers of Hemolysis and Clinical Severity in Sickle Cell Disease [0.03%]
不稳定型心绞痛患者冠状动脉慢血流的临床意义
Khouloud Khalfaoui,Mariem Chebbi,Oussema Souiai et al.
Khouloud Khalfaoui et al.
Sickle cell disease (SCD) is a monogenic disorder caused by the presence of hemoglobin S (Hb S) and is associated with a wide range of clinical complications, including hemolytic anemia, vaso-occlusive crises (VOC), and acute chest syndrome...
BNIP3L/BNIP3-Mediated Mitophagy Contributes to the Maintenance of Ovarian Cancer Stem Cells [0.03%]
BNIP3L/BINP3介导的线粒体自噬促进卵巢癌干细胞的维持作用
Na Li,Tejinder Pal Khaket,Yajing Yang et al.
Na Li et al.
Ovarian cancer remains the most lethal gynaecological malignancy, with tumour recurrence and chemoresistance posing significant therapeutic challenges. Emerging evidence suggests that cancer stem cells (CSCs), a rare subpopulation within tu...
Research Trends of Hepatic Stellate Cells in Hepatoma: A Bibliometric Analysis [0.03%]
肝细胞癌相关 hepatic stellate 细胞的研究热点及趋势——基于文献计量学分析
Qingbin Wu,Xiuju Ye,Yuhang Wang et al.
Qingbin Wu et al.
This study aims to delineate the global landscape, knowledge structure, and emerging trends of research on hepatic stellate cells (HSCs) in hepatoma from 2009 to 2023 using bibliometric methods. We retrieved 510 relevant publications from t...
TGFBI Inhibits the Pyroptosis of Macrophages to Ameliorate Septic Shock [0.03%]
TGFBI通过抑制巨噬细胞的焦亡改善脓毒症休克症状
Suzhao Zou,Lan Li,Bo Lv
Suzhao Zou
Septic shock is one of the leading causes of morbidity and mortality in hospital patients. The present study aimed to investigate the potential of transforming growth factor β induced (TGFBI) in macrophage functions and progression of sept...
Aureli Luquero,Noelia Pimentel,Gemma Vilahur et al.
Aureli Luquero et al.
Obesity is a major cause of chronic disease morbidity-mortality. Understanding the mechanisms triggering its promotion will allow the development of effective treatments. Cardiovascular diseases are associated with high-fat diet ingestion; ...