miR-640 Enhances Abemaciclib Sensitivity by Suppressing CDK Inhibitor Resistance-Associated Genes in Breast Cancer Cells [0.03%]
微RNA-miR-640通过抑制乳腺癌细胞中的CDK抑癌基因来增强阿贝西利的敏感性
Ismail Mert Alkac,Cigir Biray Avci
Ismail Mert Alkac
We investigated the potential of miR-640 to downregulate CDK4/6 inhibitor resistance-associated genes and evaluated its apoptotic, anti-metastatic and anti-proliferative effects, both alone and in combination with abemaciclib in breast canc...
miR-640 Enhances Abemaciclib Sensitivity by Suppressing CDK Inhibitor Resistance-Associated Genes in Breast Cancer Cells [0.03%]
微RNA-miR-640通过抑制乳腺癌细胞中的CDK抑制剂抗性相关基因来增强阿贝西利的敏感性
Ismail Mert Alkac,Cigir Biray Avci
Ismail Mert Alkac
We investigated the potential of miR-640 to downregulate CDK4/6 inhibitor resistance-associated genes and evaluated its apoptotic, anti-metastatic and anti-proliferative effects, both alone and in combination with abemaciclib in breast canc...
The Role and Mechanism of Berberine as a Candidate Drug for the Treatment of Radiation-Induced Intestinal Injury [0.03%]
小檗碱防治放射性肠损伤的研究进展及机制探讨
Xihao Liu,Li Guo,Lu Guo et al.
Xihao Liu et al.
Radiation-induced intestinal injury (RIII) is among the most common complications of radiotherapy in patients with abdominaltumours. At present, there are no effective methods for reducing the occurrence or severity of RIII. Berberine (BBR)...
Single-Cell RNA Sequencing Revealed the Role of Interferon-Gamma Related Genes in Primary Sjögren's Syndrome [0.03%]
单细胞RNA测序揭示了一类与γ干扰素相关基因在原发性舍格伦综合征中的作用
Lei Shi,Tian-Chi Wei,Jing Zhang
Lei Shi
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder. Dysregulated interferon-gamma (IFN-γ) signalling is implicated in pSS pathogenesis, yet the underlying mechanisms remain elusive. This study aimed to identify key IFN-γ-a...
Multi-Omics Profiling Identifies Novel Therapeutic Targets and Pathobiological Mechanisms in Oral Cancer [0.03%]
多组学谱分析确定了口腔癌症的新的治疗靶点及病理生物学机制
Meishan Huang,Hongwei Wang,Xiaoqiang Mo et al.
Meishan Huang et al.
Oral cancer (OC) remains a therapeutic challenge due to limited validated targets. Cis-pQTLs from the deCODE cohort (n = 35,559) were harmonized with OC-GWAS (3547 cases and 691,466 controls) meta-data through a two-sample Mendelian randomi...
HDAC2-Mediated SMAD7 Stabilisation Activates Wnt/β-Catenin Signalling to Drive DNA Damage Repair and Cisplatin Resistance in Ovarian Cancer [0.03%]
组蛋白去乙酰化酶2介导的SMAD7稳定激活Wnt/β-catenin信号促进卵巢癌细胞DNA损伤修复和顺铂耐药性
Yingying He,Meiling Wu,Xiaomin Xu et al.
Yingying He et al.
To investigate the role of histone deacetylase 2 (HDAC2) in cisplatin resistance in ovarian cancer (OC). Cisplatin-resistant OC cell lines were employed to construct HDAC2 overexpression and knockdown models, and their effects on cell proli...
β3-AR/β-arrestin2 Interaction Triggers Cardiac Fibrosis Through JNK/c-Jun Pathway in Cardiac Fibroblasts [0.03%]
心房纤维化病灶中β3肾上腺素受体通过JNK/c-jun通路触发心脏成纤维细胞活化的机制研究
Zhongcheng Xu,Min Zhu,Chun Zhou et al.
Zhongcheng Xu et al.
Myocardial fibrosis (MF) is a critical pathological substrate of heart failure (HF), and β3-adrenergic receptor (β3-AR) has been implicated in cardiac remodelling with controversial roles. This study aimed to clarify the pro-fibrotic mech...
Inhibiting HIF-1α-Induced miR-663b Improves Pulmonary Arterial Hypertension by Reducing Dysfunctions of PASMCs Through Repressing Sirt1-ZBP1-Mediated PANoptosis [0.03%]
抑制HIF-1α诱导的miR-663b通过抑制Sirt1-ZBP1介导的PANoptosis改善肺动脉高压血管平滑肌细胞功能异常
Le Shen,Honghong Ma,Yang Yu et al.
Le Shen et al.
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by vascular remodelling. Inflammatory responses and oxidative stress have been shown to contribute to its progression. This study investigated the effects of a nov...
Neurofilament Light Chain (Nfl) Level in Serum as a Suitable In Vivo Biomaker for Axonal Damage in a Murine Viral Model of Multiple Sclerosis [0.03%]
血清神经丝轻链(NFL)水平作为评估小鼠病毒模型多发性硬化轴突损伤的体内生物标志物的适用性研究
A Segna,R Wannemacher,K Rohn et al.
A Segna et al.
Neurofilament light chain (Nfl) is a protein of the cytoskeleton predominantly found in large calibre myelinated axons and a suitable in vivo biomarker for monitoring neurodegenerative processes. Axonal damage results in Nfl release into th...
Monocyte Single-Cell-Type Gene Expression Analysis Differentiates Kawasaki Disease From Viral Infection With High Specificity [0.03%]
单细胞基因表达分析鉴别川崎病与病毒感染能力较强
Nelson L S Tang,Tsz-Ki Kwan,Assunta C H Ho et al.
Nelson L S Tang et al.
Kawasaki disease (KD) and viral infection (VD) share similar clinical features but require distinct treatments. A practical biomarker to distinguish them is therefore clinically important. Previous blood transcriptome studies identified man...