RETRACTION: Melatonin Modulates Mitophagy, Innate Immunity and Circadian Clocks in a Model of Viral-Induced Fulminant Hepatic Failure [0.03%]
撤销论文：褪黑素通过调节线粒体自噬、先天免疫和昼夜钟来缓解病毒诱导的急性肝衰模型中的损伤
I. Crespo, P. Fernández-Palanca, B. San-Miguel, M. Álvarez, J. González-Gallego, and M.J. Tuñón, "Melatonin Modulates Mitophagy, Innate Immunity and Circadian Clocks in a Model of Viral-Induced Fulminant Hepatic Failure," Journal of Ce...
Utilises Machine Learning Techniques to Deeply Analyse the Role of Lysosome-Dependent Cell Death in Endometrial Cancer and Its Interactions With the Tumour Microenvironment [0.03%]
利用机器学习技术深入分析溶酶体依赖性细胞死亡在子宫内膜癌中的作用及其与肿瘤微环境的相互作用
Wu Min,Fang Mo,Tang Yun et al.
Wu Min et al.
By integrating gene expression data, clinical features and multimodal data, we constructed a machine learning model capable of accurately predicting the prognosis of endometrial cancer patients. The study found that key genes related to lys...
Endoplasmic Reticulum Stress: A Novel Target for the Prevention and Treatment of Hypertension and Its Related Diseases [0.03%]
内质网应激：高血压及其相关疾病防治的新靶点
Xin Ma,Fei Si,Jie Ma et al.
Xin Ma et al.
Endoplasmic reticulum stress (ERS) emerges as a critical pathophysiological nexus in hypertension and related cardiovascular diseases. Chronic ERS activation via the IRE1α-XBP1, ATF6, and PERK pathways drives vascular endothelial dysfuncti...
Integrated Analysis of the LncRNA-Mediated ceRNA Network Associated With Prognosis in Posttreatment Recurrent Nasopharyngeal Carcinoma [0.03%]
与治疗后复发性鼻咽癌预后相关的长链非编码RNA介导的ceRNA网络的综合分析
Qihong Liu,Jingxiao Lu,Zhiqiang Wang et al.
Qihong Liu et al.
The competing endogenous RNA hypothesis offers new insights into tumour progression, yet its role in posttreatment nasopharyngeal carcinoma relapse remains unclear. This study constructed ceRNA networks to identify molecular markers associa...
Revealing Causal Protein Biomarkers and Potential Therapeutic Targets for Histologic-Specific Lung Cancer [0.03%]
揭示组织学特异性肺癌的因果蛋白质生物标志物和潜在治疗靶点
Wen Sun,Jingyang Liu,Jiayan Li et al.
Wen Sun et al.
Considering the distinct etiological pathways and molecular characteristics of different lung cancer subtypes, it is crucial to develop subtype-specific prevention strategies and therapeutic targets. This study aimed to identify protein bio...
Lactylation Genes LDHA and LDHC Alleviate Osteoarthritis by Reducing Specific B-Cell Expression: Mechanistic Exploration and Experimental Validation [0.03%]
乳酰化基因LDHA和LDHC通过减少特定B细胞表达缓解骨关节炎：机制探索与实验验证
Jingkai Di,Zijian Guo,Yijing Di et al.
Jingkai Di et al.
This study aims to elucidate the correlation between the lactylation-related genes and the progression of knee osteoarthritis (KOA). Integrating genome-wide association study data and expression quantitative trait locus data, Mendelian rand...
Anticancer Activity of Annonacin and Its Synergistic Enhancement of Docetaxel Efficacy in Prostate Cancer [0.03%]
annonacin的抗肿瘤活性及其增效二氢青蒿素治疗前列腺癌的效果
Yunbei Xiao,Qinquan Wang,Chen Sun et al.
Yunbei Xiao et al.
Prostate cancer (PCa) is the second most prevalent malignancy in men, and therapeutic options become severely limited once androgen deprivation therapy (ADT) fails. This study evaluated the antitumor activity of Annonacin, a natural acetoge...
Development and Validation of a Prognostic Model for Lung Cancer Based on Machine Learning and Immune Microenvironment Analysis [0.03%]
基于机器学习和免疫微环境分析的肺癌预后模型的开发与验证
Xiong Zhang,Fei Liu
Xiong Zhang
Lung cancer prognosis varies significantly among patients, highlighting the need for accurate prediction tools. Emerging evidence suggests that the immune microenvironment plays a crucial role in lung cancer progression and treatment respon...
Repeated Exposure to Lidocaine Induces Alzheimer's-Like Cognitive Impairment Neuropathology in Aged Mice Through BDNF-Regulated Autophagy [0.03%]
利多卡因反复暴露通过BDNF调节的自噬在年老小鼠中诱导阿尔茨海默病样的认知障碍和神经病理学
Yongxin Huang,Yanhua Guo,Honghong Zhang et al.
Yongxin Huang et al.
Lidocaine is widely used for perioperative pain management, but repeated exposure may cause neurotoxicity, including neurological deficits. This study investigates mechanisms underlying cognitive decline induced by repeated lidocaine exposu...
SNHG26 Promotes Colorectal Cancer Progression via CDKN2A-Dependent Regulation of Cuproptosis and CD8+ T Cell-Mediated Immunity [0.03%]
SNHG26通过CDKN2A依赖性调节铜死亡和CD8+T细胞介导的免疫促进结直肠癌进展
Ziang Wan,Shan Gao
Ziang Wan
Long non-coding RNAs (lncRNAs) play important roles in colorectal cancer (CRC) progression. However, the biological function and regulatory mechanism of small nucleolar RNA host gene 26 (SNHG26) in CRC remain largely unexplored. SNHG26 expr...