CDK12/13 Inhibition Induces DNA Hypomethylation and Sensitizes Cancer Cells to Compounds Targeting DNA-PK [0.03%]
靶向CDK12/13可致DNA低甲基化并使肿瘤细胞对靶向DNA-PK的小分子敏感
Jing Liang,Aishwarya Gondane,Harri M Itkonen
Jing Liang
Inactivation of the major transcription elongation kinase, cyclin-dependent kinase 12 (CDK12), characterizes a subset of aggressive prostate cancers but it is not known how cells adapt and even benefit from this event. We show that mutation...
Corylin Confers Vasoprotection via JDP2-Nrf2 Antioxidant Axis against Chronic Kidney Disease-Induced Smooth Muscle Cell Remodelling [0.03%]
香豆素通过JDP2-Nrf2抗氧化信号轴对慢性肾脏病诱导的血管平滑肌细胞重构发挥保护作用
Shang-En Huang,Chih-Le Lin,Kazunari K Yokoyama et al.
Shang-En Huang et al.
Vascular calcification is a pathological process involving vascular smooth muscle cells (VSMCs) phenotypic switching into osteoblast-like cells within a calcium phosphate-deposited environment. This transformation is a critical risk factor ...
IL-6 Promotes Pathological Angiogenesis in Oral Submucous Fibrosis by Suppressing USP10-VEGFR1 Interaction [0.03%]
IL-6通过抑制USP10-VEGFR1相互作用促进口腔黏膜纤维化病理血管生成
Chunyu Li,Lingshuang Han,Zhenhao Wang et al.
Chunyu Li et al.
Oral submucous fibrosis (OSF) is a chronic, progressive, premalignant disorder with expanding epidemiology, rising annual incidence, and increasing malignant transformation rates. Therefore, elucidating its pathogenesis and establishing ear...
ANXA1-Derived Peptide Increases Melanoma Cell Sensitivity to Vemurafenib by Downregulating EphA2 [0.03%]
annexin a1 衍生的多肽通过下调 ephrin a2 增加恶性黑色素瘤细胞对 vemurafenib 的敏感性
Juan Feng,Xiao-Pu Huang,Ming Zhang et al.
Juan Feng et al.
Vemurafenib (VEM) is a BRAF inhibitor that improves the prognosis of melanoma, but acquired resistance represents a key limitation to its clinical efficacy. This study investigated the potential of A11, an Annexin A1 (ANXA1)-derived peptide...
Unveiling the New Trick for Epigenetic Drug: Radiation Enhancement of Prostate Cancer by the EZH2 Inhibitor Tazemetostat [0.03%]
表观遗传药物的新机制：Tazemetostat联合放疗治疗前列腺癌的实验研究
Tian-Qi Du,Yuhong Ou,Rui-Ji Liu et al.
Tian-Qi Du et al.
The enhancer of zeste homologue 2 inhibitor (EZH2i) Tazemetostat (EPZ-6438) has demonstrated antitumour efficacy in various malignancies. This study aims to evaluate its radiosensitising potential and underlying mechanisms in prostate cance...
Interleukin-23 Receptor and Interleukin-17 Receptor A: Splice Variants, Isoforms and Their Relationship With Periodontitis-A Systematic Review and Bioinformatic Analysis [0.03%]
白细胞介素-23受体和白细胞介素-17受体A：剪接变体，异构体及其与牙周炎的关系-系统评价和生物信息学分析
Mario Alberto Alarcón-Sánchez,Celia Guerrero-Velázquez,Daniel Ortuño-Sahagún et al.
Mario Alberto Alarcón-Sánchez et al.
This systematic review aimed to: (1) identify the splicing variants of IL23R and IL17RA reported in the literature; (2) perform a multiple alignment analysis to describe the isoforms of IL-23R and IL-17RA; and (3) compare the expression lev...
The Mechanistic Study of Melatonin Regulation of p16Ink4a and Oct4 in Anti-Cellular Senescence [0.03%]
褪黑素调控p16ink4a和Oct4抑制细胞衰老的机制研究
Yang Xu,Cong Zhang,Li Wang et al.
Yang Xu et al.
Melatonin is a multifunctional indole hormone with established roles in anti-aging and tissue regeneration. Although it has been shown to modulate key senescence-associated markers such as p16Ink4a (p16) and OCT4, the underlying molecular m...
Toxoplasma gondii-Derived Soluble Factors Induce G2/M Phase Accumulation and p53-Associated Mitochondrial Apoptosis in Human Umbilical Cord Mesenchymal Stem Cells [0.03%]
刚地弓形虫诱导人脐带间充质干细胞G₂/M周期阻滞及p53相关的线粒体凋亡路径激活
Wei Zhou,Tingyu Chen,Ziping Yang et al.
Wei Zhou et al.
Toxoplasma gondii infection poses potential risks to stem cell-based therapeutic applications; however, the effects of parasite-derived soluble factors on mesenchymal stem cells remain unclear. Here, we investigated the impact of T. gondii-...
An Ultrastructural and Proteomic Analysis in DM1 Young Adults' Myoblasts: Stressed RER and Mitochondrial Dysfunction Involvement [0.03%]
DM1年轻成人肌母细胞的超微结构和蛋白质组分析：内质网和线粒体功能障碍的参与
Renata Del Carratore,Alessandra Falleni,Margherita Bernardeschi et al.
Renata Del Carratore et al.
Myotonic dystrophy type 1 (DM1) is a progressive muscular disorder caused by the expansion of CTG repeats in the 3' UTR of the DMPK gene. Although the pathogenic mechanisms remain unclear, recent evidence suggests that activation of innate ...
The Significance of the Regulation Between tRF-31-U5YKFN8DYDZDD and BMPER in the Pathogenesis of Gastric Cancer (GC) [0.03%]
tRF-31-U5YKFN8DYDZDD和BMPER调控在胃癌发生发展中的意义
Yuejiao Huang,Xun Li,Yu Zhang et al.
Yuejiao Huang et al.
tsRNAs are a kind of small non-coding single-stranded RNA, which play an important role in many kinds of tumours. Previous studies have identified that tRF-31-U5YKFN8DYDZDD can be used as a novel tumour biomarker for the diagnosis and progn...