Precision microbiome medicine and therapeutics: the enabling role of in vitro gut models [0.03%]
精准的微生物组医学和治疗：体外肠道模型的作用
Zhan Huang,Siew C Ng,Harry Sokol et al.
Zhan Huang et al.
The human gut microbiome exhibits profound interindividual variability, challenging the efficacy of generalized interventions and underscoring the need for precision approaches to microbiome-associated diseases. Such strategies require comp...
Hybrid Histidine Kinases Shape the Architecture of the High Osmolarity Glycerol (HOG) Pathway: From Saccharomyces cerevisiae to the Priority Pathogen Aspergillus fumigatus and other Filamentous Fungi [0.03%]
组氨酸激酶缔造的高渗甘油(HOG)通路结构：从酿酒酵母到重要条件致病菌烟曲霉及其他丝状真菌
Sebastian Schruefer,Yanning Hu,Frank Ebel
Sebastian Schruefer
The HOG pathway enables adaptation to hyperosmotic and other environmental stresses. This review highlights key differences between the pathway in Saccharomyces cerevisiae and in filamentous fungi, focusing on the major pathogen Aspergillus...
The Race between Viral Immune Evasion and the MHC Class I Antigen Processing Pathway [0.03%]
病毒免疫逃逸与MHC I类抗原加工途径的竞赛
Yu Ye,Ying Zhang,Haobing Nie et al.
Yu Ye et al.
Viral immune evasion of the major histocompatibility complex class I (MHC-I) antigen processing and presentation (APP) pathway is a centerpiece of the art of deception that enables persistence, reinfection, and severe disease. It does so by...
Decoding dark septate endophyte symbiosis: A functional and ecological perspective [0.03%]
解码暗 Septate内生菌共生关系：功能和生态学视角
Keerthi Mandyam,Ari Jumpponen
Keerthi Mandyam
Plant root microbial symbioses influence plant performance and ecosystem processes. Among these, dark septate endophyte (DSE) fungi are ubiquitous, non-mycorrhizal root endophytes with broad host ranges that facilitate nutrient acquisition,...
Reagan Lee,Wonjae Kim,Jihye Bae et al.
Reagan Lee et al.
Sulfoquinovosyldiacylglycerol (SQDG) is a ubiquitous sulfolipid of phototroph membranes, including those of oxygenic phototrophs and some anoxygenic phototrophic bacteria, and its headgroup sulfoquinovose (SQ) represents one of the most abu...
Organosulfur Scaffolds as Quorum Sensing and Biofilm Modulators in Gram-Negative Bacteria [0.03%]
喹诺酮类和生物被膜调节因子在革兰氏阴性菌中的作用器官硫骨架作为革兰氏阴性细菌的群体感应和生物被膜调节因子
David C Nwobodo,Melford C Egbujor,Sammy Kiprotich et al.
David C Nwobodo et al.
Quorum sensing (QS) is a cell-density-dependent communication system that coordinates bacterial virulence, biofilm formation, motility, and stress adaptation, making it a compelling target for antivirulence intervention. Due to the possibil...
The natural history of a biocrust architect, the cyanobacterium Microcoleus vaginatus [0.03%]
微藻Microcoleus vaginatus的自然历史
Ferran Garcia-Pichel
Ferran Garcia-Pichel
The filamentous cyanobacterium Microcoleus vaginatus is a pioneer soil colonizer and the most important microorganism for the formation of cyanobacterial biological soil crusts (or biocrusts), biofilm-like communities developing on soil sur...
From Photosynthetic Electron Flow to Gene Regulation: Redox Signal Transduction in Cyanobacteria [0.03%]
从光合作电子传递到基因调控：蓝藻中的红氧信号转导机制研究
Zachary Johnson,Bin Yang,Pavlo Bohutskyi
Zachary Johnson
In cyanobacteria, the free-living ancestors of chloroplasts, photosynthesis simultaneously sustains growth and generates reactive oxygen species (ROS) that damage proteins, lipids, and DNA when light capture outpaces carbon fixation. Mainta...
Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in non-model ectotherms [0.03%]
利用 Caenorhabditis elegans 模型探究提升非模式变温动物抗逆性的微生物群干预手段
Charlotte Sprason,Philip Donkersley,Jason P Chin et al.
Charlotte Sprason et al.
Ectotherms make up most animal species and deliver essential services to ecosystems and human food supply chains but are highly vulnerable to environmental perturbations. Being vastly underrepresented in laboratory-based studies, we also cr...
Feeding the invaders: How metabolic imbalance shapes infection and biofilm development [0.03%]
养活入侵者：代谢失衡如何影响感染和生物膜发育
Sahil Mahajan,Sarah MacDowell,Cortney Mitchem et al.
Sahil Mahajan et al.
Infectious and metabolic disorders have risen sharply and pose a significant threat to human populations worldwide. Despite being deemed unrelated, mounting evidence indicates that metabolic disorders markedly heightened both the likelihood...