Toll Like Receptors Signaling Pathways as a Target for Therapeutic Interventions [0.03%]
以 Toll 样受体信号通路作为治疗干预手段
Agnieszka Jezierska,Irina A Kolosova,Alexander D Verin
Agnieszka Jezierska
This review summarizes the key role of Toll-Like Receptor (TLRs) molecules for igniting the immune system. Activated by a broad spectrum of pathogens, cytokines or other specific molecules, TLRs trigger innate immune responses. Published da...
Yawen Zeng,Jiazhen Yang,Juan Du et al.
Yawen Zeng et al.
Sleep is a vital segment of life, however, the mechanisms of diet promoting sleep are unclear and are the focus of research. Insomnia is a general sleep disorder and functional foods are known to play a key role in the prevention of insomni...
The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression [0.03%]
O-GlcNAc修饰在真核基因表达调控中的作用
Sandii Brimble,Edith E Wollaston-Hayden,Chin Fen Teo et al.
Sandii Brimble et al.
O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins has been shown to be involved in many different cellular processes, such as cell cycle control, nutrient sensing, signal transduction, stress response and transcriptional r...
The Hepatocyte Growth Factor Receptor: Structure, Function and Pharmacological Targeting in Cancer [0.03%]
肝细胞生长因子受体：结构、功能及癌症治疗的药理靶点
Fabiola Cecchi,Daniel C Rabe,Donald P Bottaro
Fabiola Cecchi
Under normal conditions, hepatocyte growth factor (HGF)-induced activation of its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand delivery, ligand activation at the target cell surface, and liga...
Mohammed I Khan,Anna M Czarnecka,Renata Duchnowska et al.
Mohammed I Khan et al.
Metastasis is a complex process that propagates cells from the primary or initial site of the cancer occurrence to distant parts of the body. Cancer cells break from the cancer site and circulate through the bloodstream or lymph vessels, al...
Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC) [0.03%]
透明细胞肾细胞癌(tyrosine kinase inhibitors)获得性耐药机制研究进展
Zofia F Bielecka,Anna M Czarnecka,Wojciech Solarek et al.
Zofia F Bielecka et al.
Clear - cell renal cell carcinoma (ccRCC) is a histological subtype of renal cell carcinoma - the most prevalent adult kidney cancer. Causes of ccRCC are not completely understood and therefore number of available therapies is limited. As a...
Mammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell Carcinoma [0.03%]
雷帕霉素靶点抑制剂耐药机制在透明细胞肾细胞癌中的作用
Anna Kornakiewicz,Wojciech Solarek,Zofia F Bielecka et al.
Anna Kornakiewicz et al.
Mammalian target of rapamycin (mTOR) is a kinase protein involved in PI3K/AKT signaling with a central role in the processes of cell growth, survival and angiogenesis. Frequent mutations of this pathway make upstream and downstream componen...
Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops [0.03%]
癌症细胞通过激活补偿信号环而对靶向治疗产生耐药性
Viktoria von Manstein,Chul Min Yang,Diane Richter et al.
Viktoria von Manstein et al.
The emergence of low molecular weight kinase inhibitors as "targeted" drugs has led to remarkable advances in the treatment of cancer patients. The clinical benefits of these tumor therapies, however, vary widely in patient populations and ...
Liver X Receptor: Crosstalk Node for the Signaling of Lipid Metabolism, Carbohydrate Metabolism, and Innate Immunity [0.03%]
肝X受体：脂质代谢、碳水化合物代谢和先天免疫信号的交叉对话节点
Michael B Fessler
Michael B Fessler
Liver X Receptor-α (LXRα, also known as NR1H3) and LXRβ (NR1H2) are members of the nuclear receptor superfamily of ligand-activated transcription factors, a superfamily which includes the more widely known glucocorticoid receptor, estrog...
Update on the Pathophysiological Role of Intracellular Signaling Pathways in Atherosclerotic Plaques and Ischemic Myocardium [0.03%]
动脉粥样硬化斑块和缺血心肌中细胞内信号通路病理生理作用的研究进展
Fabrizio Montecucco,Vincent Braunersreuther,Giorgio Luciano Viviani et al.
Fabrizio Montecucco et al.
Acute atherosclerotic complications, such as myocardial infarction, are often provoked by the rupture of an atherosclerotic plaque and the subsequent thrombotic occlusion of the arterial lumen, which interrupts the blood flow and renders is...