Clare M Turner,James I Elliott,Frederick W K Tam
Clare M Turner
Our knowledge and understanding of the P2 receptor signalling system in the kidney have increased significantly in the last ten years. The broad range of physiological roles proposed for this receptor system and the variety of P2 receptor s...
David G Shirley,Renu M Vekaria,Jean Sévigny
David G Shirley
Members of all four families of ectonucleotidases, namely ectonucleoside triphosphate diphosphohydrolases (NTPDases), ectonucleotide pyrophosphatase/phosphodiesterases (NPPs), ecto-5'-nucleotidase and alkaline phosphatases, have been identi...
P Darwin Bell,Peter Komlosi,Zhi-Ren Zhang
P Darwin Bell
Within each nephro-vascular unit, the tubule returns to the vicinity of its own glomerulus. At this site, there are specialised tubular cells, the macula densa cells, which sense changes in tubular fluid composition and transmit information...
Bellamkonda K Kishore,Raoul D Nelson,R Lance Miller et al.
Bellamkonda K Kishore et al.
The kidneys play a critical role in the maintenance of water homeostasis. This is achieved by the inherent architecture of the nephron along with the expression of various membrane transporters and channels that are responsible for the vect...
Matthew A Bailey,David G Shirley
Matthew A Bailey
A range of P2 receptor subtypes has been identified along the renal tubule, in both apical and basolateral membranes. Furthermore, it has been shown that nucleotides are released from renal tubular cells, and that ectonucleotidases are pres...
Scott Sp Wildman,Esther S-K Kang,Brian F King
Scott Sp Wildman
Sodium balance determines the extracellular fluid volume and sets arterial blood pressure (BP). Chronically raised BP (hypertension) represents a major health risk in Western societies. The relationship between BP and renal sodium excretion...
R J Unwin,D G Shirley
R J Unwin
Helle A Praetorius,Jens Leipziger
Helle A Praetorius
All cells release nucleotides and are in one way or another involved in local autocrine and paracrine regulation of organ function via stimulation of purinergic receptors. Significant technical advances have been made in recent years to qua...
Edward W Inscho
Edward W Inscho
Purinoceptors are rapidly becoming recognised as important regulators of tissue and organ function. Renal expression of P2 receptors is broad and diverse, as reflected by the fact that P2 receptors have been identified in virtually every ma...
P2Y1R-IGFBP2 signaling: new contributor to astrocyte-neuron communication [0.03%]
P2Y1R-IGFBP2信号通路：星形胶质细胞-神经元通讯新因子
In a recent article published in Nature Communications (Shigetomi et al Nat Commun 15(1):6525, 2024), Shigetomi et al. identified that upregulated astrocytic purinergic P2Y1 receptors (P2Y1R), acting via the downstream molecule, insulin-lik...