Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering [0.03%]
利用40赫兹光闪烁促进糖淋巴液循环：一种非侵入性策略
Jianchen Fan,Zhihua Gao
Jianchen Fan
The glymphatic system is critical for brain homeostasis by eliminating metabolic waste, whose disturbance contributes to the accumulation of pathogenic proteins in neurodegenerative diseases. Promoting glymphatic clearance is a potential an...
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation [0.03%]
小胶质细胞P2X7受体调节急性应激刺激的小鼠类似抑郁的行为反应
Xin-Yi Cheng,Wen-Jing Ren,Xuan Li et al.
Xin-Yi Cheng et al.
Acute stress causes depressive-like reactions in the tail suspension (TST) and forced swim tests (FST) of mice. Similarly, inescapable foot shock is able to promote the development of anhedonia as indicated by decreased sucrose consumption ...
Purinergic signaling in liver disease: calcium signaling and induction of inflammation [0.03%]
肝病中的嘌呤能信号传导：钙信号转导和炎症诱导
Henning Ulrich,Talita Glaser,Andrew P Thomas
Henning Ulrich
Purinergic signaling regulates many metabolic functions and is implicated in liver physiology and pathophysiology. Liver functionality is modulated by ionotropic P2X and metabotropic P2Y receptors, specifically P2Y1, P2Y2, and P2Y6 subtypes...
The P2X7R is a crucial target for Angiotensin II-induced myocardial ferroptosis and remodeling [0.03%]
P2X7受体是血管紧张素II诱导的心肌铁死亡和重塑的关键靶点
Abdel-Aziz S Shatat
Abdel-Aziz S Shatat
Ongoing cardiac remodeling can lead to negative outcomes, such as cardiac failure and diminished myocardial function, although the remodeling process initially protects the heart as a compensatory mechanism[1] . Importantly, ferroptosis app...
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor [0.03%]
艾灸预处理可减轻惊厥持续状态下的癫痫发作严重程度，并且可以抵消嘌呤能P2X7受体的致惊厥功能
Hong-Wei Zhang,Jia-Jia Li,Yulihan Tang et al.
Hong-Wei Zhang et al.
Moxibustion, traditional Chinese medicine treatment, involves the warming of specific acupuncture points of the body using ignited herbal materials. Evidence suggests beneficial effects of moxibustion in several brain diseases including epi...
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats [0.03%]
施万细胞移植改善大鼠神经损伤并缓解神经病理性疼痛
Wen-Jun Zhang,Xi Li,Jun-Xiang Liao et al.
Wen-Jun Zhang et al.
The mechanism of neuropathic pain induced by nerve injury is complex and there are no effective treatment methods. P2X4 receptor expression is closely related to the occurrence of pain. Schwann cells (SCs) play a key protective role in the ...
Astrocytic P2X7 receptor in retrosplenial cortex drives electroacupuncture analgesia [0.03%]
电针镇痛诱导 retrosplenial 外侧皮层星形胶质细胞依赖的免疫抑制
Wei Zhao,Si-Le Liu,Si-Si Lin et al.
Wei Zhao et al.
P2X7 receptor (P2X7R) has been found to contribute to the peripheral mechanism of acupuncture analgesia (AA). However, whether it plays an important role in central mechanism remains unknown. In this study, we aimed to reveal the role of as...
Regulation of transcription factor function by purinergic signalling in cardiovascular diseases [0.03%]
嘌呤能信号在心血管疾病中通过调节转录因子功能发挥作用
Hao Tang,Qihang Kong,Zhewei Zhang et al.
Hao Tang et al.
Cardiovascular diseases (CVDs), including hypertension, atherosclerosis, myocardial ischemia, and myocardial infarction, constitute the primary cause of mortality worldwide. Transcription factors play critical roles in the development of CV...
Astrocytic adenosine A2B receptors: a crucial player in brain function [0.03%]
星形胶质细胞腺苷A2B受体在脑功能中的重要作用
Cui-Yuan Chen,Yong Tang
Cui-Yuan Chen