Violeta N Mutafova-Yambolieva
Violeta N Mutafova-Yambolieva
The urinary bladder mucosa (urothelium and suburothelium/lamina propria) functions as a barrier between the content of the urine and the underlying bladder tissue. The bladder mucosa is also a mechanosensitive tissue that releases signaling...
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex [0.03%]
电针可通过下调初级皮层P2Y14受体表达来缓解炎性痛
Shuai Hou,Cui-Yuan Chen,Rui-Zhu Zhou et al.
Shuai Hou et al.
Increasing evidence indicated that purinergic signalling involved in electroacupuncture (EA)-induced analgesia. Whether purinergic P2Y14 receptor contributes to EA-mediated analgesia remains unclear. Here, we report that the expression of P...
Yong Tang,Peter Illes,Charles Kennedy
Yong Tang
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats [0.03%]
701 Dedicated Pioneering Patch活性成分的筛选及其对慢性约束损伤大鼠的镇痛作用研究
Jun Meng,Zhenglang Zhang,Yujie Wang et al.
Jun Meng et al.
An increasing number of traditional Chinese medicine(TCM) have been confirmed to possess analgesic bioactivity. 701 Dieda Zhentong patch(701-DZP) which includes 14 kinds of TCMs exhibited excellent efficacy in alleviating back or leg pain a...
Role of adenosine in the pathophysiology and treatment of attention deficit hyperactivity disorder [0.03%]
腺苷在注意缺陷多动障碍的病理生理和治疗中的作用
Qingxia Jia,Hongwan Tan,Tingsong Li et al.
Qingxia Jia et al.
Attention deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental condition characterized by persistent inattention, hyperactivity, and impulsivity. Although its precise etiology remains unclear, current evidence suggests that...
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma [0.03%]
小鼠淋巴瘤模型中P2Y12受体介导的环氧合酶2(COX-2)表达促进肿瘤细胞进展
Shilpa Sharma,Khagendra Ghimeray,Md Mostafizur Rahman et al.
Shilpa Sharma et al.
The pro-inflammatory enzyme cyclooxygenase 2 (COX-2) has been known to impart metastatic property to cancer cells. However, blocking of COX-2 with nonsteroidal anti-inflammatory drugs or COX-2-specific inhibitors has failed in clinical tria...
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7 [0.03%]
筛选草药和天然产物库以发现人类P2X7的新变构调节剂
Stefan Bidula,Waraporn Piyasirananda,Hanna Bielecka et al.
Stefan Bidula et al.
P2X7 is an emerging therapeutic target for several disorders and diseases due to its role in inflammatory signalling. This study aimed to exploit the unique chemical libraries of plants used in traditional medicinal practices to discover no...
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior [0.03%]
巨噬细胞极化中P2X7受体的作用及其对神经母细胞瘤行为的影响
Carolina Adriane Bento,Vanessa Fernandes Arnaud-Sampaio,Talita Glaser et al.
Carolina Adriane Bento et al.
Tumor-associated macrophages (TAMs) exhibit antitumor or protumor responses related to inflammatory (or M1) and alternative (or M2) phenotypes, respectively. The P2X7 receptor plays a key role in macrophage polarization, influencing inflamm...
P2 purinergic receptor expression and function in tumor-related immune cells [0.03%]
肿瘤相关免疫细胞中P2嘌呤受体的表达和功能
Vahinipriya Manoharan,Oluwafemi O Adegbayi,Janielle P Maynard
Vahinipriya Manoharan
P2 purinergic receptor expression is dysregulated in multiple cancer subtypes and is associated with worse outcomes. Studies identify roles for P2 purinergic receptors in tumor cells that drive disease aggressiveness. There is also sufficie...
Purines and purinergic receptors in primary tumors of the central nervous system [0.03%]
原发性中枢神经系统肿瘤中的嘌呤和嘌呤能受体
Adinei Abadio Soares,Helamã Moraes Dos Santos,Keyllor Nunes Domann et al.
Adinei Abadio Soares et al.
Purine nucleotides and nucleosides play critical roles in various pathological conditions, including tumor cell growth. Adenosine triphosphate (ATP) activates pro-tumor receptors, while adenosine (ADO) is a potent immunosuppressant and modu...