Tumor growth inhibitory activity of the P2X7 receptor antagonist AZ10606120 in two cell lines of human glioblastoma [0.03%]
P2X7受体拮抗剂AZ10606120抑制人类胶质母细胞瘤两个细胞系增殖的作用研究
Michela Graziano,Silvia Bono,Michela Pizzoferrato et al.
Michela Graziano et al.
Glioblastoma multiforme (GBM) is among the most aggressive and lethal primary brain tumors. P2X7 is a purinergic receptor overexpressed in GBM, whose activation can promote tumor growth. Two major splice variants of the P2X7 receptor, isofo...
Adenosine A2A receptors in the chorioid plexus are causal in mediating the development of hydrocephalus [0.03%]
脉络丛中的腺苷A2A受体介导脑积水发生发展
Xing-Ying Ren,Yong Tang,Peter Illes
Xing-Ying Ren
In a recent article published in Nature Communications, Zheng et al. report that heightened stimulation of A2A receptors (A2ARs) located in epithelial cells of the chrorioid plexus (ChP) is responsible for the development of hydrocephalus (...
Light flickering with 40 Hz causes analgesia via activation of a retina-amygdala pathway and the local release of adenosine [0.03%]
40赫兹闪烁灯光通过激活视网膜-杏仁核通路及局部腺苷释放产生镇痛作用
Wei Zhao,Yong Tang,Peter Illes
Wei Zhao
In a recent article published in Cell Research, Chen et al. reported that light flickering at 40 Hz effectively counteracts chronic pain in Complete Freund Adjuvant (CFA)-treated mice and in mice whose tibial and common peroneal nerves were...
Proteasomal-dependent endothelial P2Y6 receptor downregulation as an adaptive mechanism limiting monocyte adhesion during intestinal schistosomiasis [0.03%]
肠道血吸虫病期间内皮P2Y6受体依赖溶酶体降解的适应性下调可限制单核细胞黏附作用
Nathalia F Oliveira,Matheus M L V Monteiro,Leticia D Crepaldi et al.
Nathalia F Oliveira et al.
Schistosomiasis, a complex chronic intravascular parasitic disease caused by Schistosoma mansoni, triggers a multifaceted host immune response and drives endothelial cells toward a sustained proinflammatory phenotype. The dysfunctional endo...
Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors [0.03%]
针对阿米巴原虫的宿主导向治疗策略：靶向核苷酸受体P2受体
Mariana M Chaves,Nayara Carvalho-Barbosa,Luiz Eduardo Baggio Savio et al.
Mariana M Chaves et al.
Apicomplexan parasites establish intracellular infections that profoundly alter host cell physiology and elicit complex immune responses. The long-standing coevolution between these parasites and vertebrate hosts has resulted in extensive o...
Latest advances on the role of P2X Receptors in colorectal inflammation and cancer [0.03%]
P2X受体在结直肠炎和癌症中的作用的最新进展
Luigia Ruo,Federica Fortuna,Marianna Grignolo et al.
Luigia Ruo et al.
Extracellular adenosine triphosphate (eATP) is a hallmark of inflammatory and tumor-associated microenvironments, where it functions as a key extracellular signalling molecule through activation of purinergic receptors. In the gastrointesti...
Mixed circuit training as a non-pharmacological strategy to improve platelet function and oxidative balance in type 2 diabetes: role of purinergic signaling [0.03%]
混合电路训练作为改善2型糖尿病血小板功能和氧化平衡的非药物策略：嘌呤能信号的作用
Lucas Macedo Chaves,Samantha Nuncio Prestes,André Campos De Lima et al.
Lucas Macedo Chaves et al.
This study investigates the impact of a 16-week mixed circuit training (MCT) program on purinergic signaling and oxidative stress markers in women with type 2 diabetes mellitus (T2DM), focusing on its potential to modulate platelet-related ...
Phenolic compounds and chemotherapeutic agents differentially regulate P2X receptor subtypes in malignant melanoma [0.03%]
酚类化合物和化学治疗剂可区别调节恶性黑色素瘤中的P2X受体亚型
Serkan Sen,Sefa Celik
Serkan Sen
Melanoma is an aggressive malignancy characterized by high metastatic potential and resistance to conventional therapies. Emerging evidence suggests that purinergic P2X receptors, particularly P2X7, play critical roles in regulating tumor c...
The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies [0.03%]
P2X7受体/NLRP3炎性小体信号通路在脓毒症中的作用：分子机制、器官特异性病理生理学和新兴治疗策略
Hilal Üstündağ
Hilal Üstündağ
Sepsis remains a leading cause of mortality in intensive care units worldwide, representing life-threatening organ dysfunction arising from dysregulated host responses to infection. The purinergic P2X7 receptor (P2X7R) and the NOD-like rece...
The potential role of adenosinergic pathway and methylxanthines in Parkinson's disease: Blowing in the wind or not [0.03%]
腺苷能通路和甲基黄嘌呤在帕金森病中的潜在作用：被风刮走了还是没走？
Alaa Ismail,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Alaa Ismail et al.
Parkinson's disease (PD) is a systemic neurodegenerative disease, and is mainly related to the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Despite extensive research regarding PD neuropatho...