Depletion of P2X4 receptor alleviates prostate cancer bone metastasis through reduced cancer cell invasiveness and enhanced cell adhesion activities [0.03%]
P2X4受体耗竭通过降低癌细胞侵袭性和增强细胞粘附活性来缓解前列腺癌骨转移
Jiepei He,Yuhan Zhou,Hector M Arredondo Carrera et al.
Jiepei He et al.
Prostate cancer (PCa) preferentially metastasizes to bone, which remains incurable and contributes significantly to mortality and morbidity. The P2X4 receptor (P2X4R) is a receptor for ATP that is highly expressed in many cancer types inclu...
ATP who you are [0.03%]
阿特匹夫你是誰
Yong Tang,Peter Illes
Yong Tang
Role of macrophage ATP metabolism disorder in SiO2‑induced pulmonary fibrosis: a review [0.03%]
二氧化硅诱导肺纤维化中巨噬细胞ATP代谢紊乱的作用：综述
Hui-Jie Hu,Yuan-Yuan Fu,Shu-Ling Du et al.
Hui-Jie Hu et al.
Silicosis, a chronic lung disease, results from prolonged inhalation of silica dust (SiO2) in occupational environments, and its pathogenesis remains incompletely elucidated. Studies have shown that alveolar macrophages (AMs) play a pivotal...
Expanding the P2X7R toolbox: discovery of a novel Iodine-125 radioligand [0.03%]
扩展P2X7R工具箱：发现一种新型的碘-125放射配体
Giorgia Tempra,Carlo Matera
Giorgia Tempra
This Journal Club article reviews a 2025 study by Qiu et al. that reports the development of a novel iodine-125 radioligand targeting the purinergic P2X7 receptor (P2X7R). The researchers created a small library of structurally modified P2X...
P2Y6R together with CYSLTR2 serves as endogenous receptor for long-chain ceramides in atherosclerosis [0.03%]
长链半胱胺脂在动脉粥样硬化中P2Y6R与CYSLTR2作为内源性受体共同发挥作用
Qing Ye,Yong Tang
Qing Ye
In a recent article published in Nature, 2025 Zhang et al. identified the pyrimidinergic receptor P2Y6 (P2Y6R), together with the cysteinyl leukotriene receptor 2 (CYSLTR2), as key receptor mediating ceramide-induced atherosclerotic cardiov...
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function [0.03%]
皮肤巨噬细胞促进的P2Y6介导的FSTL1神经修剪以重置疼痛阈值和心脏功能
Yun Liu,Xiao Sun,Zhengxu Jia et al.
Yun Liu et al.
Hyperactivation of cutaneous macrophages promotes the development of chronic pain. Stimulation of nociceptive regions promotes neuroplasticity, which affects pain perception and related physiological responses. However, the specific mechani...
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery [0.03%]
次氯酸诱发的猪冠状动脉血管运动反应中的嘌呤能信号机制研究
Ashwaq Baghdadi,William R Dunn,Vera Ralevic
Ashwaq Baghdadi
Hypochlorous acid (HOCl) is generated by neutrophils during the innate immune response. ATP is released from cells by various stimuli and during inflammation but whether ATP is released by and participates in the response to HOCl is unclear...
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling [0.03%]
运动的抗炎作用与2型糖尿病：嘌呤能信号的作用
Andréia Machado Cardoso,André Campos de Lima,Aline Manica et al.
Andréia Machado Cardoso et al.
This study investigated the effects of physical exercise (PE) on the modulation of purinergic signaling and inflammatory profiles in sedentary women with type 2 diabetes mellitus (T2DM). Over 16 weeks, participants underwent a combined aero...
A new approach to psoriasis therapy: photoswitchable A3 adenosine receptor activation [0.03%]
一种新的银屑病治疗手段：可光调控的A3腺苷受体激活作用
Federica Cherchi,Elisabetta Coppi
Federica Cherchi
This Journal Club article discusses a recent study by López-Cano and collaborators, published in Journal of the American Chemical Society (López-Cano et al. Pharmacol Res 170:105731, 2021), which introduces a pioneering therapeutic approa...
Bruce Cronstein,Siddhesh R Angle
Bruce Cronstein
Published Erratum
Purinergic signalling. 2025 Mar 21. DOI:10.1007/s11302-025-10085-8 2025