Adenosine receptors and acute kidney injury: perspectives for future therapy [0.03%]
腺苷受体与急性肾损伤：未来治疗的展望
Isabela Berton Wissmann,Renata Cristina Daniel Coelho,Lilian Baseggio et al.
Isabela Berton Wissmann et al.
Adenosine is a key modulator in the pathophysiology of acute kidney injury (AKI), particularly through its influence on inflammatory pathways and renal hemodynamics. This nucleoside exerts its effects via four G protein-coupled receptors-A1...
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia [0.03%]
correction to：“嘌呤能P2X3受体和子宫内膜异位症相关痛觉过敏的作用”
Kailane Paula Pretto,Letícia de Souza Matias,Bruna Dias de Oliveira et al.
Kailane Paula Pretto et al.
Published Erratum
Purinergic signalling. 2025 Jul 30. DOI:10.1007/s11302-025-10106-6 2025
Min Wen,Qin Xu,Jinfeng Xie et al.
Min Wen et al.
Retinal diseases affect the health of millions of people worldwide and activated P2X7 receptors (P2X7Rs) are associated with the pathophysiology of a variety of retina-related diseases, including diabetic retinopathy, age-related macular de...
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia [0.03%]
嘌呤能P2X3受体与子宫内膜异位症相关的痛觉过敏的作用
Kailane Paula Pretto,Letícia de Souza Matias,Bruna Dias de Oliveira et al.
Kailane Paula Pretto et al.
Endometriosis is a chronic gynecological condition characterized by endometrial tissue outside the uterine cavity. Recent research has focused on the relationship between the purinergic system and endometriosis. As a purinergic system compo...
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult mice [0.03%]
CALHM1阻断剂CGP37157通过增加小鼠癫痫持续状态发作严重性而加剧癫痫持续状态
Meghma Mitra,Amaya Sanz Rodriguez,Norman Delanty et al.
Meghma Mitra et al.
Epilepsy is one of the most common chronic brain diseases affecting up to 70 million people worldwide. Major challenges of epilepsy treatment include the high pharmacoresistance in patients and the lack of disease-modification. Extracellula...
Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway [0.03%]
电针通过阻断P2X4R激活的p38信号通路抑制TRPV1表达缓解辣椒素致大鼠直肠内脏痛
Yahong Xue,Qinbing Zhu,Jing Zhang et al.
Yahong Xue et al.
Electroacupuncture (EA), as a combination of traditional acupuncture and modern electrotherapy, and has analgesic effects on various acute and chronic pain. It has been proved to ameliorate chronic visceral pain, but its specific role in re...
P2X3 receptors in the paraventricular hypothalamus: a specific target for visceral pain [0.03%]
腹外侧下丘脑中的P2X3受体：内脏痛的特异性靶点
Xiu-Min Hu,Yong Tang,Peter Illes
Xiu-Min Hu
In a recent article published in Neuron, Li et al. (Neuron 112(22):3734-3749.e5, 2024) accomplished a major scientific advance by reporting that ATP-sensitive P2X3 receptor-channels (P2X3Rs) in the paraventricular hypothalamus (PVH) specifi...
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock [0.03%]
鸟苷或肌苷在猪出血性休克模型中的急性效应
André P Schmidt,Denise A Otsuki,Gisele Hansel et al.
André P Schmidt et al.
Hemorrhagic shock (HS) leads to systemic hypoperfusion, impaired tissue oxygenation, and multi-organ dysfunction, including central nervous system (CNS) injury. Guanosine and inosine, purine nucleosides with neuroprotective and anti-inflamm...
State of the art indicators for imaging purinergic dynamics in vitro and in vivo [0.03%]
体外和体内成像嘌呤能动力学的最新指标研究
Yumo Li,Liwan Zhang,Bohan Li et al.
Yumo Li et al.
Purinergic neurotransmission, a dynamic signaling system using adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine (ADO), uridine diphosphate (UDP), and others, plays a crucial role in brain function. Purinergic signaling i...