Luyao Liu,Yoshiteru Kagawa,Colin L Masters et al.
Luyao Liu et al.
The human P2X7 purinergic receptor is an ATP-gated ion channel expressed across a wide range of cell types, including immune, epithelial, glial, and various cancer cells. Despite its broad expression and diverse functions, little is known a...
Increased P2X7 level does not affect anxiety or stress-coping behavior in male mice [0.03%]
P2X7水平升高不影响小鼠的焦虑和应激应对行为
Lidia Urbina-Treviño,Hao Tang,Iven-Alex von Mücke-Heim et al.
Lidia Urbina-Treviño et al.
The P2RX7 gene has been linked to various neuropsychiatric disorders. In particular, the SNP rs2230912, which results in a glutamine-to-arginine substitution at position 460, has repeatedly been associated with mood disorders. Although this...
Functional role of peripheral P2X3 receptor expression in trigeminal ganglion neurons: a microarray-based evaluation of the antagonist effect of P2X3 [0.03%]
三叉神经节神经元外周P2X3受体表达的功能作用及P2X3拮抗效应的基因芯片分析
Mika Ishikawa,Takehiro Yajima,Kentaro Mizuta et al.
Mika Ishikawa et al.
The P2X receptor is an extracellular adenosine triphosphate (ATP)-gated ion channel that plays critical roles in cellular and developmental processes, including cell proliferation, survival, and differentiation. Specifically, P2X3 is essent...
Guanosine contributes to rapid purinergic regulation of dopamine during ischemia [0.03%]
次黄嘌呤核苷通过嘌呤能系统参与缺血性损伤中的多巴胺快速释放
Moriah E Weese-Myers,Alaa S Abdelrazeq Hassan,Ashley E Ross
Moriah E Weese-Myers
Purinergic modulation of neurotransmission is a primary strategy employed in rapid neuroprotection during and after ischemic stroke. While the contributions of adenosine and ATP to the purinome are well-documented, guanosine-based regulator...
Modulation of P2X7-driven purinergic signaling and NLRP3 inflammasome activation underlies the hepatoprotective effects of coenzyme Q10 against glyphosate-based herbicide exposure [0.03%]
辅酶Q10调节P2X7介导的胶质生长抑素基除草剂嘌呤能信号和NLRP3炎性小体激活作用及其肝保护效应
Duygu Mutluay,Seda Yakut,Gözde Yücel Tenekeci et al.
Duygu Mutluay et al.
The widespread use of glyphosate-based herbicides (GBHs), including formulations such as Roundup, has raised toxicological concern due to their capacity to induce oxidative stress, inflammatory signaling, and mitochondrial dysfunction leadi...
P2X7 receptor mediates the anti-tumor effect of running on cervical cancer in mice [0.03%]
P2X7受体介导跑步对小鼠宫颈癌的抑瘤效应
Hai-Yun Xiong,Rui Li,Xiu-Min Hu et al.
Hai-Yun Xiong et al.
Previous studies have suggested that running exerts anti-tumor effects on various cancers through multiple pathways. It has been reported that the P2X7 receptor (P2X7R) may display anti-tumor activity in cervical cancer cells, and running c...
ATP and major affective disorders: the involvement of P2X receptors in pathophysiology [0.03%]
ATP与主要情感障碍：P2X受体在病理生理中的作用
Simona Mattova,Patrik Simko,Elena Colzi et al.
Simona Mattova et al.
P2X receptors, a family of ATP-gated ion channels, are increasingly recognized as key contributors to the pathophysiology of major depressive disorder. Among them, P2X7 plays a central role in stress-induced neuroinflammation by driving mic...
Purinergic signaling in dengue infection: modulation of P2 receptors as a potential therapeutic strategy [0.03%]
登革热感染中的嘌呤能信号转导：调节P2受体作为潜在的治疗策略
Vitória C de Melo,Kayla I de Oliveira,Marina Kipper et al.
Vitória C de Melo et al.
Dengue is a globally widespread arboviral disease characterized by an intense inflammatory response that may progress to severe clinical manifestations, such as dengue shock syndrome and hemorrhagic fever. The lack of effective treatments u...
Expression of purinergic receptor P2Y, G-protein coupled 2, is regulated by estrogen during the estrous cycle in mouse uterus [0.03%]
雌激素通过调节小鼠子宫P2Y14受体基因表达影响生殖道功能反抗宿主生育能力的机制研究模型初探
Joohee Kim,Minju Kang,Byeongseok Kim et al.
Joohee Kim et al.
Elucidating the molecular intricacies governing uterine function is crucial for reproductive success. The purinergic receptor P2Y, G-protein coupled 2 (P2ry2), regulates critical cellular processes, and we investigated the mechanisms by whi...
P2X7 receptor-mediated cGAS-STING pathway activation underlies chronic stress-induced depressive-like behaviors [0.03%]
P2X7受体介导的cGAS-STING通路激活参与慢性应激抑郁样行为产生
Xi-Meng He,Yi Zhang,Cui-Yuan Chen et al.
Xi-Meng He et al.
Although chronic stress is known to trigger neuroinflammation and depressive-like behaviors, the mechanisms linking stress sensors to inflammatory cascades remain elusive. The purinergic receptor P2X7 (P2X7R), an extracellular ATP-gated cat...