P2Y14 receptor activation and neutrophil signaling: linking inflammation to systemic pathophysiology [0.03%]
P2Y14受体活化与中性粒细胞信号转导：炎症和全身病理生理学之间的关联
Renan da Silva Ebone,Pedro Henrique Doleski,Matheus Henrique Jantsch et al.
Renan da Silva Ebone et al.
Neutrophils are essential effector cells of the innate immune system, acting as the first line of defense against infection and tissue injury. Among the purinergic receptors expressed in these cells, P2Y14 has gained increasing attention in...
Capsaicin suppresses LPS-induced inflammatory responses via NLRP3/CASP-1/IL-1β axis and purinergic pathways in BV-2 microglial cells [0.03%]
辣椒素通过NLRP3/CASP-1/IL-1β轴和嘌呤受体途径抑制LPS诱导的小胶质BV-2细胞炎症反应
Bianca Vedoin Copês Rambo,Milagros Fanny Vera Castro,Mairin Schott et al.
Bianca Vedoin Copês Rambo et al.
Microglial activation drives neuroinflammation, a key factor in many neurological diseases. The purinergic system is a major regulator of inflammatory responses and represents a promising target for controlling neuroinflammation. Capsaicin,...
Peter Illes,Alexei Verkhratsky,Yong Tang
Peter Illes
Current understanding of ENaC regulation by P2Y2/PLC/PI(4,5)P2 pathway [0.03%]
P2Y2/磷脂酶C/PI(4,5)P2信号通路调节上皮钠通道的机制研究进展
Tarek Mohamed Abd El-Aziz,Ahmed Al-Sabi,Lucia A Seale et al.
Tarek Mohamed Abd El-Aziz et al.
The epithelial sodium channel (ENaC) localized in the cell membrane is crucial for sodium transport and blood pressure regulation. Discovered in frog skin, ENaC is expressed in the colon, lungs, exocrine glands, and most notably in the dist...
Blockage of P2X7 receptor activation attenuated bone loss in ligature-induced model of periodontitis in rats [0.03%]
阻断P2X7受体激活可减轻牙周病模型中牙槽骨的丢失
Nadine Linhares,Marco Aurelio Teófilo,Juliane Fernandes et al.
Nadine Linhares et al.
Periodontitis is a highly prevalent immunoinflammatory disease that compromises the supporting tissues of the teeth, especially the periodontal ligament and alveolar bone. During disease progression, inflammatory responses lead to the relea...
Breast cancer patients present pro-tumor biomarkers related to purinergic signaling and oxidative stress [0.03%]
与嘌呤能信号传导和氧化应激相关的乳腺癌促肿瘤生物标志物的表达
Eduarda Valcarenghi Jabonski,Simone Luciana Triquez,Ana Paula Geraldi Norbah et al.
Eduarda Valcarenghi Jabonski et al.
Breast cancer (BC) is a multifactorial disease characterized by cell cycle disorder and immune evasion. Studies reveal that the purinergic system (PS) is a mediator of the immune system and actively participates in the inflammatory process ...
Yong Tang,Peter Illes
Yong Tang
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential [0.03%]
P2X7受体在白血病中的病理机制和治疗潜力
Yanwen Xue,Xiaoxiang Peng,Meng Yan et al.
Yanwen Xue et al.
The P2X7 receptor is a trimeric ion channel purinergic receptor. It plays a crucial part in the pathophysiology of cancers and a variety of inflammatory diseases and is widely expressed in different cell types. Leukemia represents a type of...
Astrocytes: crucial transducers that convert norepinephrine inputs to ATP signaling in the brain [0.03%]
astrocyte：将去甲肾上腺素能输入转化为脑内 ATP 信号的关键转换器
Yuto Kubota,Eiji Shigetomi,Bijay Parajuli et al.
Yuto Kubota et al.
Adenine at lower doses acts in the kidney as an aquaretic agent and prevents hyponatremia [0.03%]
腺苷小剂量时可发挥利尿作用并预防低钠血症
Alaa Alghamdi,Charuhas V Thakar,Hassane Amlal
Alaa Alghamdi
We have previously reported that adenine at high doses interferes with the vasopressin signaling pathway, causes massive diuresis and volume depletion, and ultimately leads to renal failure. In the present study, we examined the effects of ...