Turning failure into success: how artificial intelligence can help personalize therapies and re-use patient data [0.03%]
变废为宝：人工智能如何助力个性化医疗与重新利用患者数据
Maria P Abbracchio,Ernesto Damiani
Maria P Abbracchio
Despite robust preclinical evidence, many clinical trials, including several that targeted the purinergic system, fail to demonstrate efficacy in humans. Failure may stem from inability to accurately identify patient subgroups responding si...
P2Y6 receptor in the superior cervical ganglion: a key mediator of post-myocardial ischemic sympathetic hyperexcitability via NF-κB mediated neuroinflammation [0.03%]
主动脉夹层所致心脏神经炎症的机制研究及新药防治策略研究
Lifang Zou,Changyi Li,Mingshuo He et al.
Lifang Zou et al.
Myocardial ischemia (MI) often leads to sympathetic overexcitation, though the underlying mechanisms are not fully understood. This work was to elucidate the role of P2Y6 receptors in the superior cervical ganglion (SCG) in mediating sympat...
Jean Lucas Gutknecht da Silva,Jean Sévigny,Daniela Bitencourt Rosa Leal
Jean Lucas Gutknecht da Silva
Neutrophils are key innate immune cells whose effector mechanisms are increasingly recognized as therapeutic targets in chronic inflammation and cancer. While highly heterogeneous and functionally versatile, they can also exacerbate inflamm...
Positive allosteric modulator activity of ginsenosides is restricted to P2X7 and P2X4 receptors [0.03%]
人参皂苷的正变构调节活性仅限于P2X7和P2X4受体
Elizabeth Allum,Leanne Stokes
Elizabeth Allum
Positive allosteric modulators of P2X7 receptors hold promise as host-directed immune enhancers in intracellular infections. We have previously reported the use of protopanaxadiol ginsenosides as positive allosteric modulators of human, rat...
The ATP-adenosine axis as a driver of tumor-associated macrophage reprogramming in colorectal cancer: mechanistic insights into immune evasion and therapeutic vulnerabilities [0.03%]
结直肠癌中的ATP-腺苷轴在肿瘤相关巨噬细胞重编程中的驱动作用：免疫逃逸和治疗弱点的机制见解
Abdullah Faisal Albukhari
Abdullah Faisal Albukhari
Colorectal cancer progression is increasingly recognized as a process shaped not only by tumor-intrinsic genetic alterations but also by dynamic interactions within the tumor microenvironment. Tumor-associated macrophages represent a domina...
Acute effects of a single electroacupuncture session on purinergic signaling and inflammatory markers in patients with chronic nonspecific low back pain: a pilot study [0.03%]
电针单次治疗对慢性非特异性下腰痛患者嘌呤能信号传导和炎症标志物的急性影响：一项试点研究
Jardel Cristiano Ecco,Vinicius Ansolin,Adinei Abadio Soares et al.
Jardel Cristiano Ecco et al.
Chronic nonspecific low back pain (CNLBP) is a problem faced by a significant portion of the world population. However, among the strategies for treating these patients, there are pharmacological and nonpharmacological options. However, non...
Purinergic modulation in Parkinson's disease: the dual role of istradefylline in motor and cognitive outcomes [0.03%]
朴辛能调制在帕金森病中的作用：伊斯特德非林对运动和认知结果的双重作用
Mokhtar Rejili,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Mokhtar Rejili et al.
Istradefylline, a selective adenosine 2A receptor (A2AR) antagonist, was approved in 2019 as an adjuvant treatment to reduce "OFF" periods in Parkinson's disease (PD) patients. This comprehensive review evaluates its dual impact on PD, cont...
The long march towards testing the adenosine receptor agonism hypothesis for human cerebroprotection: The story of the A1R/A3R receptor agonist AST-004 [0.03%]
人类脑保护腺苷受体激动假说的长期验证之路——A1R/A3R受体激动剂AST-004的故事
Theodore E Liston,William S Korinek,Kenneth A Jacobson et al.
Theodore E Liston et al.
AST-004 is an adenosine A1R/A3R agonist and promising cerebroprotectant currently in Phase II clinical development. Clinical evaluations have been initiated in concussion, with trials in preparation for mild complicated traumatic brain inju...
The analgesic effect of electroacupuncture in alleviating paclitaxel-induced peripheral neuropathic pain and its possible mechanism relates to TLR4/P2X7-NLRP3 signaling pathway [0.03%]
电针镇痛对帕利昔露引起的外周神经病理性疼痛及TLR4/P2X7-NLRP3信号通路的影响研究
Yuan-Xi Zhou,Man-Ni Wang,Juan-Juan Xin et al.
Yuan-Xi Zhou et al.
Paclitaxel-induced peripheral neuropathic pain (PIPNP) is a common and debilitating adverse effect of chemotherapy, with limited effective treatments. Electroacupuncture (EA) has demonstrated analgesic potential in various pain models, but ...
The P2X4-P2X7 purinergic axis in alcohol-related liver disease: from fibrogenesis to immunotherapy resistance [0.03%]
乙醇相关性肝病中的P2X4-P2X7嘌呤受体轴：从纤维化到免疫治疗抵抗
Zixuan Li,Jie Qiao,Ji Qiu
Zixuan Li
Alcohol-related liver disease (ALD) is increasingly affecting younger populations globally and has become the leading cause of rising liver-related morbidity and mortality. Chronic alcohol exposure over a long period of time has been shown ...