Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea [0.03%]
从Bothrops mattogrossensis毒液中鉴定出嘌呤能系统成分及Tabebuia aurea中的specioside抑制效应
Dhébora Albuquerque Dias,Kamylla Fernanda Souza de Souza,Iluska Senna Bonfá Moslaves et al.
Dhébora Albuquerque Dias et al.
Snake bites are a severe problem in the countryside of Brazil and are usually attributed to snakes of the genera Bothrops, Crotalus, and Lachesis. Snake venom can release ectoenzymes and nucleotidases that modulate the purinergic system. In...
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain [0.03%]
电针通过抑制大鼠IBS外周敏化依赖于DRG中的P2X7和P2Y1受体
Tingting Lv,Guona Li,Chen Zhao et al.
Tingting Lv et al.
Although multiple purinergic receptors mediate the analgesic effects of acupuncture, it remains unclear whether there is mutual interaction between purinergic receptors to jointly mediate the electroacupuncture inhibition of peripheral sens...
Shu-Ya Mei,Ning Zhang,Meng-Jing Wang et al.
Shu-Ya Mei et al.
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease. The prevalent features of AD pathogenesis are the appearance of β-amyloid (Aβ) plaques and neurofibrillary tangles, which cause microglial activation, synaptic...
Correction to: Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist [0.03%]
Correction to: 非竞争性P2X4受体放射配体[Tritium]PSB-1659的制备及初步评价
Jessica Nagel,Olli Törmäkangas,Katja Kuokkanen et al.
Jessica Nagel et al.
Published Erratum
Purinergic signalling. 2024 Jun 19. DOI:10.1007/s11302-024-10030-1 2024
Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools [0.03%]
探索新型 dilation 衍生物作为 hENT1 抑制剂和潜在的共价分子工具
Majlen A Dilweg,Marina Gorostiola González,Martijn D de Ruiter et al.
Majlen A Dilweg et al.
The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport of nucleosides and nucleobases, such as adenosine. This nucleoside regulates various physiological processes, such as...
Yanni Xi,Zhenya Min,Mianxue Liu et al.
Yanni Xi et al.
P2Y12 receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet function, hemostasis, and thrombosis. P2Y12R activation can promote platelet aggregation and adhesion to cancer cells,...
Zhan-Guo Gao,Mansour Haddad,Kenneth A Jacobson
Zhan-Guo Gao
The A2B adenosine receptor (A2BR) is one of the four adenosine-activated G protein-coupled receptors. In addition to adenosine, protein kinase C (PKC) was recently found to activate the A2BR. The A2BR is coupled to both Gs and Gi, as well a...
Meng Wang,Wei Guo,Jiang-Fan Chen
Meng Wang
Obesity refers to the excessive accumulation of fat caused by a long-term imbalance between energy intake (EI) and energy expenditure (EE). Over recent years, obesity has become a major public health challenge. Caffeine is a natural product...
Curcumin modulates purinergic signaling and inflammatory response in cutaneous metastatic melanoma cells [0.03%]
姜黄素调节皮肤转移性黑色素瘤细胞的嘌呤能信号传导和炎症反应
Daiane Manica,Gilnei Bruno da Silva,Rafael Antônio Narzetti et al.
Daiane Manica et al.
Cutaneous melanoma (CM) poses a therapeutic challenge due to its aggressive nature and often limited response to conventional treatments. Exploring novel therapeutic targets is essential, and natural compounds have emerged as potential cand...
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR [0.03%]
细胞外腺苷三磷酸介导的结直肠癌进展的分子机制：嘌呤受体介导的HuR核质穿梭的作用
Abdel-Aziz S Shatat,Elsayed M Mahgoup,Mohammed H Rashed et al.
Abdel-Aziz S Shatat et al.
One of the leading causes of cancer-related deaths worldwide is colorectal cancer (CRC). Extracellular ATP (e-ATP) and purinergic receptors (P2R) play a central role in CRC proliferation and progression. Human antigen R (HuR) is becoming mo...