Expression of the P2X1 receptor remains in the type II spiral ganglion neurons in the mature rat cochlea [0.03%]
成熟大鼠耳蜗II型螺旋神经节神经元表达P2X1受体
Prakansha N Kumar,Srdjan M Vlajkovic,Peter R Thorne et al.
Prakansha N Kumar et al.
Our sense of hearing commences in the cochlea, the peripheral sensory organ for hearing. Spiral ganglion neurons (SGN) in the cochlea are primary auditory neurons responsible for auditory neurotransmission. There are two classes of SGNs: ty...
Fernanda Cardoso da Silva,Jeferson Stabile,Cristina Ribas Fürstenau et al.
Fernanda Cardoso da Silva et al.
Cancer is a group of diseases characterized by disordered cell proliferation and loss of tissue architecture. Breast cancer (BC) is the most common and lethal cancer among women, standing out for its molecular, histological and pathological...
P2X4 receptors as the dynamic regulators of auditory sensory cell activity: a potential new mechanism for protecting hearing? [0.03%]
P2X4受体作为听觉感觉细胞活性的动态调节因子：一种新的听力保护机制？
Alizée Fisher-Ridoux,Haruna Suzuki-Kerr
Alizée Fisher-Ridoux
Resistance exercise exerts anti-hypertensive effects and downregulates NTPDase/CD39 and ecto-5'-nucleotidase/CD73 expression in patients with chronic kidney disease undergoing hemodialysis [0.03%]
阻力运动发挥抗高血压作用并下调血液透析慢性肾脏病患者NTDPase/CD39和外核糖核苷酸酶/CD73的表达
Angela Makeli Kososki Dalagnol,Francini Franscescon,Matheus Chimelo Bianchini et al.
Angela Makeli Kososki Dalagnol et al.
Chronic kidney disease (CKD) affects approximately 13.4% of the global population and significantly impacts patients' quality of life. This study aimed to investigate the effects of resistance exercise on blood pressure and purinergic signa...
Spinal P2X3 receptors blockade reverses paclitaxel-induced allodynia in rats [0.03%]
顺铂诱发的癌痛模型大鼠脊髓P2X3受体拮抗作用的镇痛效应研究
Pedro Segura-Chama,Lucio Antonio Ramos-Chávez,Nashiely Yañez-Recendis et al.
Pedro Segura-Chama et al.
Allodynia to mechanical stimuli is one of the most prevalent symptoms in paclitaxel-treated cancer patients. Paclitaxel induces ATP release from nerve terminals; thus, peripheral primary sensory neurons can be sensitized by ATP, as a large ...
Integrins α3 and α6 promote Th17 cell migration by activating the purinergic receptor P2X4 [0.03%]
整合素α3和α6通过激活嘌呤能受体P2X4促进Th17细胞迁移
Chakib Hamoudi,Anahita Lashgari,Fawzi Aoudjit
Chakib Hamoudi
Interactions of effector T cells with laminins during their trafficking across basement membranes play a crucial role in the development of the adaptive immune response and inflammatory diseases. However, the mechanisms involved in this pro...
Abnormal purinergic signaling contributes to development of renal cysts in autosomal dominant polycystic kidney disease [0.03%]
自体显性多囊肾病中异常的嘌呤能信号促进肾囊肿的发展
Veniamin Ivanov,Andrew Wu,Letizia Crocetti et al.
Veniamin Ivanov et al.
Polycystic kidney diseases (PKD) are a group of inherited nephropathies marked by the formation of fluid-filled cysts along the nephron, which cause renal failure. Bulk RNA sequencing of microdissected renal cysts from Pkd1RC/RC mice identi...
The role and therapeutic potential of purinergic signaling pathway in metabolic syndrome-related atherosclerosis [0.03%]
与代谢综合征相关的动脉粥样硬化中嘌呤能信号通路的作用及治疗潜力
Xiang Li,Chengxin Gong,Chengxiao Fu et al.
Xiang Li et al.
Metabolic syndrome (MetS) is a cluster of interrelated and co-occurring metabolic disorders, including abdominal obesity, hyperglycemia, dyslipidemia, the reduced high-density lipoprotein (HDL) cholesterol, and/or hypertension. Cardiovascul...
Acupuncture alleviates postoperative hemorrhoid pain by modulating the P2X7/ERK pathway [0.03%]
针灸通过调节P2X7/ERK途径缓解术后痔痛
Bin Chen,Tian Wang,Jie Gao et al.
Bin Chen et al.
Postoperative pain following hemorrhoid surgery is often accompanied by emotional and cognitive disturbances, complicating recovery. Acupuncture has shown promise in modulating pain and related neuroinflammatory pathways. A rat model of mix...
Adenosine A2A receptors in the nucleus accumbens regulate stress resilience and predict susceptibility to stress-induced affective disturbances [0.03%]
伏隔核腺苷A2A受体调节压力抗压性和预测应激引起的情感障碍的易感性
Laura Menegatti Bevilacqua,Francisco da Silveira Neto,Axel Fogaça Rosado et al.
Laura Menegatti Bevilacqua et al.
Individual variability in stress responses contributes to susceptibility or resilience to mood and anxiety disorders. The adenosinergic system, particularly A1 and A2A receptors, modulates synaptic activity in brain regions involved in emot...