The P2X7 receptor: insights from the murine monoclonal antibody clone L4 [0.03%]
P2X7受体的研究进展——L4小鼠单克隆抗体的启示
Ronald Sluyter,Amal Elhage,Rachael Bartlett et al.
Ronald Sluyter et al.
The P2X7 receptor (or P2X7) is an ATP-gated ion channel with important roles in the immune and other body systems. Much has been garnered about P2X7 using the first published anti-human P2X7 monoclonal antibody (mAb) (clone L4). This mAb ca...
Is adenosine signalling entering the precision medicine era? From receptor pharmacology to patient stratification [0.03%]
腺苷信号通路进入精准医疗时代吗？从受体药理学到患者分层
Luca Antonioli,György Haskó
Luca Antonioli
Over the past three decades, adenosine signalling has emerged as a fundamental regulatory system controlling immune responses, tissue homeostasis, metabolism, and repair processes. The identification of four adenosine receptor subtypes and ...
Inflammation, oxidative stress and purinergic signaling in pituitary neuroendocrine tumors (PitNETs) [0.03%]
垂体神经内分泌肿瘤(PitNETs)中的炎症、氧化应激和嘌呤能信号转导
Yenidis Teilor Scheibel,Symon Martins,André Paulo Turcatel et al.
Yenidis Teilor Scheibel et al.
Pituitary neuroendocrine tumors (PitNETs) constitute a heterogeneous group of intracranial neoplasms with variable biological behavior, whose aggressiveness cannot be explained solely by the intrinsic characteristics of tumor cells. Growing...
Responsiveness to adenosine diphosphate on carotid arterial and platelet functions in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats [0.03%]
腺苷二磷酸对OSS大鼠颈动脉和血小板功能影响的实验研究
Hideaki Tagashira,Kumiko Taguchi,Takayuki Nagano et al.
Hideaki Tagashira et al.
Extracellular nucleotides, including adenosine diphosphate (ADP), are pivotal in regulating vascular and platelet function. Thus, their abnormal function contributes significantly to the initiation and progression of diabetic complications....
The effect of P2RX7 functional SNPs on osteoblast cell phenotype, function and signalling- roles in bone homeostasis and osteogenesis [0.03%]
P2RX7功能SNPs对成骨细胞表型、功能和信号传导的影响及其在骨骼稳态和骨发生中的作用
Luke Tattersall,Qiguang Wang,Anna Lisa Giuliani et al.
Luke Tattersall et al.
Bone cells are known to express multiple purinergic receptors. These are involved in various aspects of bone physiology depending on the cell type and receptor involved, both in normal and disease states, with extracellular ATP being partic...
Selective P2X3 versus dual P2X2/3 receptor antagonists in refractory chronic cough: a systematic review and dose-response meta-analysis of randomized controlled trials [0.03%]
选择性P2X3与双效P2X2/P2X3受体拮抗剂治疗难治性慢性咳嗽的系统评价和剂量反应meta分析
Jeevarathinam Thirumalai,Indra Sivakumar,Saravanan Sekaran
Jeevarathinam Thirumalai
Extracellular adenosine triphosphate (ATP)-mediated purinergic signalling via P2X3 and heteromeric P2X2/3 ion channel receptors underlies hypersensitisation of vagal airway afferents in refractory chronic cough (RCC), making this pathway a ...
Paul-Pierre Boutet
Paul-Pierre Boutet
In a recent publication in Proceedings of the National Academy of Science, Wang et al. explore the structural and physiological outcomes of P2X3 receptor (P2X3R) activation by MgATP2- and ATP4-, two endogenous forms of ATP. The authors find...
Correction to: The analgesic effect of electroacupuncture in alleviating paclitaxel-induced peripheral neuropathic pain and its possible mechanism relates to TLR4/P2X7-NLRP3 signaling pathway [0.03%]
Correction to：“电针镇痛对紫杉醇外周神经病理性疼痛的干预作用及其可能机制与TLR4/P2X7-NLRP3信号通路有关”
Yuan-Xi Zhou,Man-Ni Wang,Juan-Juan Xin et al.
Yuan-Xi Zhou et al.
Published Erratum
Purinergic signalling. 2026 Jun 10;22(3):57. DOI:10.1007/s11302-026-10169-z 2026
Adenosine A2A receptor signaling in neuroinflammation, glial modulation, and mechanisms associated with chronic pain [0.03%]
腺苷A2A受体在神经炎症、胶质细胞调节和慢性疼痛机制中的信号传导作用
Clara Andressa Barros,Jéssica Gonçalves Rangel,Bruno de Oliveira Cruz et al.
Clara Andressa Barros et al.
Chronic pain is increasingly recognized as a complex and multidimensional condition that extends beyond peripheral nociceptive input, encompassing maladaptive central mechanisms such as persistent neuroinflammation, glial dysfunction, aberr...
Benzamide derivatives as allosteric ligands of the human and rat P2X7 receptor [0.03%]
苯甲酰胺衍生物作为人和大鼠P2X7受体变构激动剂的研究
Andrea Spinaci,Aleksei Smirnov,Beatrice Francucci et al.
Andrea Spinaci et al.
The P2X7 receptor (P2X7R) is a key player of the purinergic signalling and is widely expressed throughout the body. The involvement of this protein in the regulation of physiological processes and the onset and progression of pathological c...