Functional divergence of zebrafish keap1 paralogs revealed by CRISPR/Cas9-mediated gene editing: a specialized role for keap1b in inflammation [0.03%]
利用CRISPR/Cas9基因编辑揭示斑马鱼keap1冗余基因的功能分化：KEAP1B在炎症反应中具有特殊功能
Vu Thanh Nguyen,Bui Thi Thu Van,Tran Ngoc Uyen et al.
Vu Thanh Nguyen et al.
The Keap1/Nrf2 signaling pathway is a master regulator of cellular defense against oxidative and electrophilic stress. In teleosts like zebrafish (Danio rerio), whole-genome duplication resulted in two keap1 paralogs, keap1a and keap1b, who...
Deciphering the cucumber ATG6 and its promoter to enhance abiotic stress tolerance and drive stress-responsive transgene expression in plants [0.03%]
黄瓜ATG6及其启动子的解析及在提高植物逆境抗性和驱动胁迫响应的目的基因表达中的应用研究
Issariya Dachphun,Phasanat Supphokha,Supachai Vuttipongchaikij et al.
Issariya Dachphun et al.
Developing climate-resilient plants with enhanced tolerance to abiotic stresses such as drought and salinity is essential for mitigating the impact of climate change on agriculture. One promising approach is the heterologous expression of s...
Avenues of genome editing for color trait improvement in ornamental fishes: current status and future perspectives [0.03%]
观赏鱼类色彩性状改良的基因组编辑途径：现状与未来展望
S S Priyanka,Gowhar Iqbal,N C Nidarshan et al.
S S Priyanka et al.
Ornamental fish industries are growing sectors contributing significantly to livelihood, trade and export, driven by the worldwide demand for colourful and unique species. Pigmentation is the focal point of the visual appeal of ornamental f...
A novel tamoxifen-inducible Mct8-CreERT2 mouse model for targeted studies of Mct8-expressing cells and thyroid hormone transport and function [0.03%]
一项新颖的他莫昔芬诱导型Mct8-CreERT2小鼠模型用于靶向研究表达Mct8的细胞和甲状腺激素转运及功能
Anna Molenaar,Noémi Mallet,Marin Bralo et al.
Anna Molenaar et al.
Deficiency of the Monocarboxylate Transporter 8 (MCT8) severely impairs thyroid hormone (TH) transport into the brain, disrupting brain development as well as peripheral TH homeostasis. Studies assessing MCT8 expression patterns and tissue-...
Advancements in genomic crop techniques and considerations for regulation and food safety [0.03%]
基因组作物技术的发展及其管理与食品安全方面的考虑因素
Gijs W Spaans,Jan Pieter van der Berg,Lianne M S Bouwman et al.
Gijs W Spaans et al.
Advancements in genomic crop techniques have led to the development of new genetic technologies, such as base- and prime editing, but improvements have been made to existing conventional techniques as well. Fields in which these advancement...
An efficient system for plastid transformation in an edible medicinal herb [0.03%]
一种药用经济植物的高效遗传转化体系
Zike Ding,Zhoujing Gao,Xinyu Lv et al.
Zike Ding et al.
Transplastomic technology has found diverse applications in metabolic and resistance engineering, yet its implementation has been primarily limited to select plant species like Nicotiana tabacum. Here we report a robust and reproducible pla...
Editorial Expression of Concern: Expression of bioactive human interferon-gamma in transgenic rice cell suspension cultures [0.03%]
对用人转基因水稻细胞培养表达活性人干扰素γ论文的编辑观察
Tzy-Li Chen,Yi-Ling Lin,Yi-Ling Lee et al.
Tzy-Li Chen et al.
Highly efficient transgenesis mediated by Tip100 transposon system in medaka [0.03%]
斑马鱼中高效整合的Tip100转座系统
Yoshitaka Tanaka,Takahide Seki,Atsushi Hoshino et al.
Yoshitaka Tanaka et al.
Transgenesis mediated by transposon is an effective approach for introducing exogenous DNA into the nuclear genome and establishing stable transgenic strains that efficiently express genetic tools. Although the DNA transposon Tol2 is widely...
A novel recombinant CRISPR/Cas9 vector system for genome editing in plants [0.03%]
植物基因组编辑的新型重组CRISPR/Cas9载体系统
Krishnayan Paul,Venkat Raman K,Mahi Baaniya et al.
Krishnayan Paul et al.
Genome editing employing CRISPR/Cas9 systems has found widespread applications for knocking out targeted genes. In spite of exponential applications in plants for trait improvement, low editing efficiency in plants is a major concern. We re...
Generation of a Ym1 deficient mouse utilising CRISPR-Cas9 in CB6 embryos [0.03%]
利用CRISPR-Cas9技术在CB6胚胎中生成Ym1缺陷小鼠
J E Parkinson,G E Baldwin,P H Papotto et al.
J E Parkinson et al.
Chitinase-like proteins (CLPs) are of wide interest due to their significant roles during both homeostatic and pathological processes. Human CLPs such as YKL-40 have been proposed as biomarkers of disease severity in many conditions. Murine...