Improved Core Viscosity Achieved by PDLLA10kCo-Incorporation Promoted Drug Loading and Stability of mPEG2k-b-PDLLA2.4k Micelles [0.03%]
聚乳酸共掺杂改善mPEG2k-b-PDLLA2.4k胶束的核心粘度，提高载药量及稳定性
Chen Guo,Ying Zhang,Haoyang Yuan et al.
Chen Guo et al.
Purpose: This study aims to investigate the effect of poly(D, L-lactic acid)10K (PDLLA10K) incorporation on the drug loading and stability of poly(ethylene glycol)2K-block-poly(D, L-lactide)2.4K (mPEG2k-b-PDLLA2.4k) micel...
Comparative Study
Pharmaceutical research. 2022 Feb;39(2):369-379. DOI:10.1007/s11095-022-03174-5 2022
Correction to: Identification of the Specific Causes of Polysorbate 20 Degradation in Monoclonal Antibody Formulations Containing Multiple Lipases [0.03%]
Correction to: 多种脂肪酶抗体制剂山梨醇酐酯20降解的特定原因识别
Sisi Zhang,Caterina Riccardi,Douglas Kamen et al.
Sisi Zhang et al.
Published Erratum
Pharmaceutical research. 2022 Feb;39(2):425. DOI:10.1007/s11095-022-03168-3 2022
Scott G Summerfield,James W T Yates,David A Fairman
Scott G Summerfield
The Free Drug Hypothesis is a well-established concept within the scientific lexicon pervading many areas of Drug Discovery and Development, and yet it is poorly defined by virtue of many variations appearing in the literature. Clearly, unb...
Zhi Ping Gordon Xu
Zhi Ping Gordon Xu
Endosome escape is a key process for intracellular uptake of intact biomolecules and therapeutics, such as nucleic acids. Lysosome escape is a more common pathway during endocytosis, while some biomolecular, organic and inorganic materials ...
Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier [0.03%]
巴比妥类和抗抑郁药通过大鼠血脑屏障的膜转运蛋白产生的脑内分布差异研究
Shin-Ichi Akanuma,Myeongrae Han,Yuka Murayama et al.
Shin-Ichi Akanuma et al.
Purpose: The present study aimed to elucidate the transport properties of imipramine and paroxetine, which are the antidepressants, across the blood-brain barrier (BBB) in rats. ...
Retraction Note to: Nanoformulation of Apolipoprotein E3-Tagged Liposomal Nanoparticles for the Co-Delivery of KRAS-siRNA and Gemcitabine for Pancreatic Cancer Treatment [0.03%]
胰腺癌治疗联合递送KRAS-siRNA和吉西他滨的ApoE3标记脂质体纳米粒的 nanoformulation 的撤稿通知
Fengyong Wang,Zhen Zhang
Fengyong Wang
Retraction of Publication
Pharmaceutical research. 2022 Feb;39(2):423. DOI:10.1007/s11095-022-03181-6 2022
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3 [0.03%]
基于处方药物库的有机阳离子转运体3(OCT3)抑制剂的高通量筛选
Eugene C Chen,Pär Matsson,Mina Azimi et al.
Eugene C Chen et al.
Introduction: The organic cation transporter 3 (OCT3, SLC22A3) is ubiquitously expressed and interacts with a wide array of compounds including endogenous molecules, environmental toxins and prescription drugs. Understudi...
Correction to: The Influence of Stabilized Deconjugated Ursodeoxycholic Acid on Polymer-Hydrogel System of Transplantable NIT-1 Cells [0.03%]
Correction to：“鹅去氧胆酸单体型对NIT-1细胞移植微囊聚合物水凝胶体系的影响”
Armin Mooranian,Rebecca Negrulj,Hani Al-Salami
Armin Mooranian
Published Erratum
Pharmaceutical research. 2022 May;39(5):1025. DOI:10.1007/s11095-021-03142-5 2022
Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gel Formulations for the Treatment of Impaired Vascular Function: an Ex Vivo Study [0.03%]
一种氢硫酸盐供体ADT-OH的透皮给药：用于治疗血管功能障碍的水性凝胶制剂的体内研究
Mandeep Kaur Marwah,Hala Shokr,Lissette Sanchez-Aranguren et al.
Mandeep Kaur Marwah et al.
Purpose: Hydrogen sulphide (H2S) is an important signalling molecule involved in the regulation of several physiological and pathophysiological processes. The objective of this study was to investigate the feasibility of ...
Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers [0.03%]
鼠胎盘MDR1对某些药物胎儿暴露有限影响的解释：相邻合体滋养层之间旁路转运的作用
Arimi Fujita,Saki Noguchi,Rika Hamada et al.
Arimi Fujita et al.
Purpose: Multidrug resistance protein 1 (MDR1) is located at the interface between two syncytiotrophoblast layers in rodent placenta, and may influence fetal drug distribution. Here, we quantitatively compare the function...