Nano-DSF Technology as a Preliminary Decision-Making Tool for Long Term Stability Evaluation of Covid-19 Vaccine Antigens [0.03%]
Rahul Misra,Siddhant Sharma,Manjit Haer et al.
Rahul Misra et al.
Purpose: Nano differential scanning fluorimetry (nano-DSF) is a high-throughput screening technique that simultaneously assesses colloidal and conformational stabilities of protein antigens by monitoring their thermal unf...
Microdermabrasion with Calcium Hydrogen Phosphate for Enhancing Skin Permeation of Lidocaine-tetracaine Eutectic Microemulsion Gel [0.03%]
Ying Chen,Yuye Yang,Jin Su et al.
Ying Chen et al.
Background: Transdermal drug delivery (TDD) offers a convenient administration for treating local or systemic diseases. However, the dense "brick-mortar" structure of the stratum corneum hinders the skin permeation of mos...
Pharmaceutical Stability of Romiplostim: In-use Functional Study Using Microscale Thermophoresis New Strategy and Elisa [0.03%]
Jesús Hermosilla,Salvador Casares-Atienza,Julio Ruiz-Travé et al.
Jesús Hermosilla et al.
Objective: Functional stability is crucial for therapeutic proteins at all stages of their lifecycle. Romiplostim (Nplate®) is world-wide used for treating immune thrombocytopenia purpura. Limited in-use stability data o...
Mucolytic Core-Shell Particles to Boost Levofloxacin Penetration Through the Mucus Barrier in Cystic Fibrosis [0.03%]
Valentina Ruggiero,Francesca Mariano,Domenico Larobina et al.
Valentina Ruggiero et al.
Purpose: The purpose of this study was to investigate multi-fluid spray drying as a formulation strategy to engineer inhalable microparticles containing levofloxacin and mucolytic agents, and to evaluate how formulation a...
Recent Progress in Exosome-Derived Nanocarriers for Breast Cancer Therapy: Advances, Translational Barriers, and Scale-Up Considerations [0.03%]
Julie R Youssef,Esraa M Elgammal,Dina M Mahdy et al.
Julie R Youssef et al.
Breast cancer remains the most prevalent malignancy among women worldwide and a major cause of cancer-related mortality. Despite remarkable progress in molecularly targeted and immune-based therapies, therapeutic resistance, dose-limiting s...
Yutong Tian,Shihao Song,Yaojie Shi et al.
Yutong Tian et al.
Background: Titanium dioxide (TiO2) is widely used as a white additive in food and pharmaceuticals, but its safety has raised increasing concerns. Currently, calcium carbonate is commonly used as an alternative to TiO2 in...
The Use of Digital Image Processing in the Modelling of a Roller Compaction Milling Operation [0.03%]
David Wilson,Alexa Mesham,Felix Tim Bölle
David Wilson
Purpose: Granulation by roller compaction is an important unit operation in the production of pharmaceutical oral solid dosages. This process involves producing a densified "ribbon" of compressed powder between two counte...
The Role of Cyclodextrins in Modulating Stimuli-Responsiveness for Anticancer Drug Delivery [0.03%]
环糊精在调节抗癌药物递送刺激响应性中的作用
Andrea Cesari,Liu Zhengming,Fabio Bellina
Andrea Cesari
Background: The precision delivery of active pharmaceutical ingredients remains a major challenge in modern pharmacology, where conventional therapies often lack selectivity and cause severe side effects. Stimuli-responsi...
The Impact of Particle Properties on High Concentration Suspension Performance and Stability of Spray-Dried Monoclonal Antibodies [0.03%]
颗粒属性对高浓度喷雾干燥单克隆抗体稳定性的影响分析
Yijing Huang,Jiaying Liu,Ruomeng Qiu et al.
Yijing Huang et al.
Objective: Subcutaneous (subQ) administration of biologic drug products is increasingly preferred to enable patient self-administration and reduce healthcare burden. However, the small dosing volume for subQ delivery nece...
The Versatile Role of GDF5 in Chondrogenic Progenitor Cell-mediated Cartilage Regeneration via a Hyaluronic Acid-fibrin IPN Hydrogel Platform [0.03%]
GDF5在透明质酸-纤维蛋白IPN水凝胶平台介导的软骨祖细胞活化及软骨再生中的多功能作用研究
Rui He,Venkateswaran Ganesh,Pornpoj Phruttiwanichakun et al.
Rui He et al.
Objective: Focal damage to articular cartilage incurred during joint injuries frequently progresses to post-traumatic osteoarthritis (PTOA) due to the limited intrinsic repair capacity of cartilage. Chondrogenic progenito...