Dual Drug Loaded pH-sensitive Micelles for Efficient Bacterial Infection Treatment [0.03%]
一种高效的抗菌感染治疗的双药负载型pH敏感型胶束疗法
Yingxian Chen,Qian Zhao,Junhua Han et al.
Yingxian Chen et al.
Purpose: Methicillin-resistant Staphylococcus aureus (MRSA) infection at impaired wound is associated with high risks of developing to persistent bacterial infections since bacterial biofilm is easy to form in MRSA infect...
Computational Fluid Dynamics (CFD) Guided Spray Drying Recommendations for Improved Aerosol Performance of a Small-Particle Antibiotic Formulation [0.03%]
计算流体动力学(CFD)引导的喷雾干燥建议，可改善小颗粒抗生素配方的气溶胶性能
Worth Longest,Amr Hassan,Dale Farkas et al.
Worth Longest et al.
Purpose: The objective of this study was to implement computational fluid dynamics (CFD) simulations and aerosol characterization experiments to determine best-case spray drying conditions of a tobramycin excipient enhanc...
Comparative Study
Pharmaceutical research. 2022 Feb;39(2):295-316. DOI:10.1007/s11095-022-03180-7 2022
Meta-Analysis of Drug Delivery Approaches for Treating Intracellular Infections [0.03%]
用于治疗细胞内感染的药物递送方法的meta分析研究
Sooyoung Shin,Soonbum Kwon,Yoon Yeo
Sooyoung Shin
This meta-analysis aims to evaluate the trend, methodological quality and completeness of studies on intracellular delivery of antimicrobial agents. PubMed, Embase, and reference lists of related reviews were searched to identify original a...
Susceptibility of Lung Carcinoma Cells to Nanostructured Lipid Carrier of ARV-825, a BRD4 Degrading Proteolysis Targeting Chimera [0.03%]
BRD4降解型蛋白酶靶向嵌合体ARV-825纳米结构脂质载体对肺癌细胞的敏感性
Richa Vartak,Aishwarya Saraswat,Yuqi Yang et al.
Richa Vartak et al.
The present work was aimed at developing an optimized and modified nanostructured lipid carrier of BRD4 protein degrading Proteolysis Targeting Chimera (PROTAC) against non-small cell lung carcinoma. PROTACs are an emerging class of antican...
A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice [0.03%]
一个半生理三室模型描述了清醒小鼠在静脉注射后蔗糖和山梨醇的脑摄取清除以及外排
Behnam Noorani,Ekram Ahmed Chowdhury,Faleh Alqahtani et al.
Behnam Noorani et al.
Purpose: To evaluate a three-compartmental semi-physiological model for analysis of uptake clearance and efflux from brain tissue of the hydrophilic markers sucrose and mannitol, compared to non-compartmental techniques p...
Comparison of Sinus Deposition from an Aqueous Nasal Spray and Pressurised MDI in a Post-Endoscopic Sinus Surgery Nasal Replica [0.03%]
关于鼻内喷雾和压力气雾剂在内镜鼻窦手术后鼻模型窦腔沉积的比较研究
Joey Siu,James van Strien,Rosa Campbell et al.
Joey Siu et al.
Background: Optimising intranasal distribution and retention of topical therapy is essential for effectively managing patients with chronic rhinosinusitis, including those that have had functional endoscopic sinus surgery...
Comparative Study
Pharmaceutical research. 2022 Feb;39(2):317-327. DOI:10.1007/s11095-021-03129-2 2022
Assessment of High-Power Electronic Nicotine Delivery System as an Alternative Aerosol Device for Terbutaline Delivery [0.03%]
高强度功率电子尼古丁传送系统作为特布他林输送的替代气溶胶装置的效果评估研究
Mariam Chaoui,Sophie Chevrel,Sophie Perinel-Ragey et al.
Mariam Chaoui et al.
Purpose: The performance of new-generation high-power electronic nicotine delivery system (ENDS) for the administration of inhaled terbutaline was assessed. ...
3D Printing Methyl Cellulose Hydrogel Wound Dressings with Parameter Exploration Via Computational Fluid Dynamics Simulation [0.03%]
基于计算流体动力学模拟的甲基纤维素水凝胶伤口敷料的参数探索及三维打印研究
Jia Heng Teoh,Faheemah Tasneem Abdul Shakoor,Chi-Hwa Wang
Jia Heng Teoh
Purpose: To investigate and optimize the use of methyl cellulose in the fabrication of three-dimensional (3D) printed drug-loaded hydrogel wound dressings for the treatment of burns. ...
Control of Drug-Excipient Particle Attributes with Droplet Microfluidic-based Extractive Solidification Enables Improved Powder Rheology [0.03%]
基于液滴微流控萃取固化控制药物辅料颗粒属性以改善粉体流变学性质
Denise Z L Ng,Arif Z Nelson,Gareth Ward et al.
Denise Z L Ng et al.
Purpose: Industrial implementation of continuous oral solid dosage form manufacturing has been impeded by the poor powder flow properties of many active pharmaceutical ingredients (APIs). Microfluidic droplet-based partic...
Model-Based Assessment of the Contribution of Monocytes and Macrophages to the Pharmacokinetics of Monoclonal Antibodies [0.03%]
基于模型的单克隆抗体药代动力学中单核细胞和巨噬细胞贡献的评估
Paul R V Malik,Abdullah Hamadeh,Andrea N Edginton
Paul R V Malik
Purpose: We have hypothesized that a high concentration of circulating monocytes and macrophages may contribute to the fast weight-based clearance of monoclonal antibodies (mAbs) in young children. Exploring this hypothes...