Dissolution Profiles of Carbamazepine Cocrystals with Cis-Trans Isomeric Coformers [0.03%]
卡马西平与顺式和反式异构共形式共晶的溶解度曲线
Maaya Omori,Hibiki Yamamoto,Fumiya Matsui et al.
Maaya Omori et al.
Purpose: The purpose of the present study was to investigate the dissolution profiles of cocrystals with cis-trans isomeric coformers. Previously, the carbamazepine (CBZ) cocrystals with even-carbon dicarboxylic acids sho...
Improving the Effectiveness of the Conical Screen Mill as a Dry-Coating Process at Lab and Manufacturing Scale [0.03%]
改进圆锥式气流磨作为干法涂层工艺在实验室和工业规模上的效果
Maxx Capece,Jeffery Larson
Maxx Capece
The conical screen mill (comill) is investigated as a dry-coating process for flowability and bulk density enhancement of pharmaceutical powders. In this study, the effectiveness of the comill is improved by using modified screens with redu...
Utility of High Resolution 2D NMR Fingerprinting in Assessing Viscosity of Therapeutic Monoclonal Antibodies [0.03%]
高分辨率二维NMR指纹图谱在治疗性单克隆抗体粘度评估中的应用价值
Subhabrata Majumder,Deep S Bhattacharya,Alex Langford et al.
Subhabrata Majumder et al.
Purpose: The viscosity of highly concentrated therapeutic monoclonal antibody (mAb) formulations at concentrations ≥ 100 mg/mL can significantly affect the stability, processing, and drug product development for subcutan...
Phyllis Chan,Kirill Peskov,Xuyang Song
Phyllis Chan
Model-based meta-analysis (MBMA) is a quantitative approach that leverages published summary data along with internal data and can be applied to inform key drug development decisions, including the benefit-risk assessment of a treatment und...
Amruta A Dandekar,Harsha T Garimella,Carrie L German et al.
Amruta A Dandekar et al.
Purpose: To investigate in vitro transdermal delivery of tofacitinib citrate across human skin using microporation by microneedles and iontophoresis alone and in combination. ...
Yoshiyuki Akiyama,Naoya Matsumura,Asami Ono et al.
Yoshiyuki Akiyama et al.
Purpose: In drug discovery, rats are widely used for pharmacological and toxicological studies. We previously reported that a mechanism-based oral absorption model, the gastrointestinal unified theoretical framework (GUT ...
Role of Surfactants on Release Performance of Amorphous Solid Dispersions of Ritonavir and Copovidone [0.03%]
两性离子表面活性剂对利托那韦与共聚维酮无定形固态分散体释放性能的影响研究
Anura S Indulkar,Xiaochun Lou,Geoff G Z Zhang et al.
Anura S Indulkar et al.
Purpose: To understand the role of different surfactants, incorporated into amorphous solid dispersions (ASDs) of ritonavir and copovidone, in terms of their impact on release, phase behavior and stabilization of amorphou...
Comparative Study
Pharmaceutical research. 2022 Feb;39(2):381-397. DOI:10.1007/s11095-022-03183-4 2022
Antibody-Targeted Liposomes for Enhanced Targeting of the Blood-Brain Barrier [0.03%]
用于增强血脑屏障靶向的抗体定向脂质体
Zhou Ye,Benjamin D Gastfriend,Benjamin J Umlauf et al.
Zhou Ye et al.
The blood-brain barrier (BBB) hinders therapeutic delivery to the central nervous system (CNS), thereby impeding the development of therapies for brain injury and disease. Receptor-mediated transcytosis (RMT) systems are a promising way to ...
Combination Cancer Immunotherapy with Dendritic Cell Vaccine and Nanoparticles Loaded with Interleukin-15 and Anti-beta-catenin siRNA Significantly Inhibits Cancer Growth and Induces Anti-Tumor Immune Response [0.03%]
树突状细胞疫苗联合负载白细胞介素15和抗β-连环素siRNA的纳米颗粒的组合癌症免疫治疗可显著抑制肿瘤生长并诱导抗肿瘤免疫反应
Armin Mahmoud Salehi Kheshti,Farnaz Hajizadeh,Asal Barshidi et al.
Armin Mahmoud Salehi Kheshti et al.
Purpose: The invention and application of new immunotherapeutic methods can compensate for the inefficiency of conventional cancer treatment approaches, partly due to the inhibitory microenvironment of the tumor. In this ...
Engineering and Characterization of a Biomimetic Microchip for Differentiating Mouse Adipocytes in a 3D Microenvironment [0.03%]
一种用于鉴别三维微环境中小鼠脂肪细胞的仿生芯片的设计与特性分析研究
Yu-Ting Chen,Latha Ramalingam,Celine R Garcia et al.
Yu-Ting Chen et al.
Although two-dimensional (2D) cell cultures are the standard in cell research, one pivotal disadvantage is the lack of cell-cell and cell-extracellular matrix (ECM) signaling in the culture milieu. However, such signals occur in three-dimen...