Hannah M Harris,Katherine L Boyet,Hao Liu et al.
Hannah M Harris et al.
Purpose: Intranasally administered unfractionated heparin (UFH) and other sulfated polysaccharides are potential prophylactics for COVID-19. The purpose of this research was to measure the safety and pharmacokinetics of c...
A Novel Fluoro-Pyrazine-Bridged Donor-Accepter-Donor Fluorescent Probe for Lipid Droplet-Specific Imaging in Diverse Cells and Superoxide Anion Generation [0.03%]
一种新型含氟吡嗪桥连给体-受体-给体型荧光探针用于多种细胞中脂滴特异成像及超氧阴离子生成
Yang Li,Qiutang Wang,Siyi Wei et al.
Yang Li et al.
Purpose: Lipid droplets (LDs) are dynamic organelles which associated with many metabolic processes. Reliable long-term imaging of LD is of great importance in LD-based therapy and research. Conventional fluorescent probe...
Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients [0.03%]
基于项目的药代动力学模型在外推中的应用：慢性阻塞性肺疾病患者的事后分析
Carolina Llanos-Paez,Claire Ambery,Shuying Yang et al.
Carolina Llanos-Paez et al.
Purpose: The current study aimed to illustrate how a non-linear mixed effect (NLME) model-based analysis may improve confidence in a Phase III trial through more precise estimates of the drug effect. ...
Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B2 Catalyst Under Visible Light Irradiation [0.03%]
维生素B2催化剂在可见光照射下使索林达克和奥扎格雷盐发生光异构化反应
Mayuko Suga,Kosho Makino,Hidetsugu Tabata et al.
Mayuko Suga et al.
Purpose: Photoisomerization of the E/Z-alkene structures of drugs is a matter of concern as it could result in potency loss and adverse side effects. This study focused on light-induced isomerization of sulindac and ozagr...
Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture [0.03%]
基于颗粒表面结构设计的海带硫酸多糖修饰的PIBCA纳米粒的内吞途径研究
M C B Lira-Nogueira,V P Gibson,V Nicolas et al.
M C B Lira-Nogueira et al.
Purpose: This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming that this might determine their efficienc...
Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue- Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations [0.03%]
氟氯西林在骨和软组织中的群体药代动力学研究-标准剂量不能达到有效的治疗浓度
Kristina Öbrink-Hansen,Anh Duc Pham,Mats Bue et al.
Kristina Öbrink-Hansen et al.
Purpose: Flucloxacillin is a β-lactam penicillin commonly used in the treatment of bone and soft tissue infections. In a recent porcine study, we found surprisingly low time for which the free concentration was maintaine...
Vehicles for Drug Administration to Children: Results and Learnings from an In-Depth Screening of FDA-Recommended Liquids and Soft Foods for Product Quality Assessment [0.03%]
儿童用药给药装置的筛查结果及经验总结：FDA 推荐液体和软食产品的质量评估
Lisa Freerks,Wenke Sucher,Marie-Josefin Tarnow et al.
Lisa Freerks et al.
Purpose: Mixing with liquids or soft foods is a common procedure to improve acceptability of oral medicines in children but may affect drug stability and the in vivo performance of the administered drug product. The aim o...
Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect [0.03%]
基于钙离子远程加载弱酸到pH敏感型脂质体并借助胞吞“ proton sponge effect”增强其在癌细胞内的胞吐释放研究
Mimi M Yang,Sasi Bhushan Yarragudi,Stephen M F Jamieson et al.
Mimi M Yang et al.
While delivery of chemotherapeutics to cancer cells by nanomedicines can improve therapeutic outcomes, many fail due to the low drug loading (DL), poor cellular uptake and endosomal entrapment. This study investigated the potential to overc...
Using a Model-based Material Sparing Approach for Formulation and Process Development of a Roller Compacted Drug Product [0.03%]
基于模型的物料节约方法在辊压固体制剂 formulation 和工艺开发中的应用
Kalyan V Vasudevan,Yu Elaine Pu,Hossein Amini et al.
Kalyan V Vasudevan et al.
The present work details a material sparing approach that combines material profiling with Instron uniaxial die-punch tester and use of a roller compaction mathematical model to guide both formulation and process development of a roller-com...
Direct Granule Feeding of Thermal Droplet Deposition 3D Printing of Porous Pharmaceutical Solid Dosage Forms Free of Plasticisers [0.03%]
不含增塑剂的热液滴沉积直接药丸打印技术制造多孔药物固体制剂
Thomas McDonagh,Peter Belton,Sheng Qi
Thomas McDonagh
Purpose: To develop a new direct granule fed 3D printing method for manufacturing pharmaceutical solid dosage forms with porous structures using a thermal droplet deposition technology. ...