Predicting Viable Skin Concentration: Modelling the Subpapillary Plexus [0.03%]
预测有效的皮肤浓度：模型皮下plexus
Joshua J Calcutt,Michael S Roberts,Yuri G Anissimov
Joshua J Calcutt
The skin concentration of a substance after a topical application or exposure determines both local treatment outcomes and the dermal toxicity assessment of various products. However, quantifying the time course of those concentrations at s...
Towards a better understanding of the role of stabilizers in QESD crystallizations [0.03%]
稳定剂在QESD结晶中的作用机制研究
Jerome Hansen,Peter Kleinebudde
Jerome Hansen
Quasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles ...
The Extension of the LeiCNS-PK3.0 Model in Combination with the "Handshake" Approach to Understand Brain Tumor Pathophysiology [0.03%]
结合“握手”方法扩展LeiCNS-PK3.0模型以理解脑肿瘤病理生理学
Makoto Hirasawa,Mohammed A A Saleh,Elizabeth C M de Lange
Makoto Hirasawa
Micrometastatic brain tumor cells, which cause recurrence of malignant brain tumors, are often protected by the intact blood-brain barrier (BBB). Therefore, it is essential to deliver effective drugs across not only the disrupted blood-tumo...
In Vitro - in Vivo Extrapolation of Hepatic Clearance in Preclinical Species [0.03%]
临床前物种肝清除的体外-体内推导
David A Tess,Sangwoo Ryu,Li Di
David A Tess
Accurate prediction of human clearance is of critical importance in drug discovery. In this study, in vitro - in vivo extrapolation (IVIVE) of hepatic clearance was established using large sets of compounds for four preclinical species (mou...
Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery [0.03%]
脑靶向药物传输的药蛋白质组学及底物设计
Kristiina M Huttunen,Tetsuya Terasaki,Arto Urtti et al.
Kristiina M Huttunen et al.
One of the major reasons why central nervous system (CNS)-drug development has been challenging in the past, is the barriers that prevent substances entering from the blood circulation into the brain. These barriers include the blood-brain ...
Makhloufi Zoulikha,Wei He
Makhloufi Zoulikha
Chronic lymphocytic leukemia (CLL) still represents an incurable disorder that may progress to other more aggressive types of cancer despite the available therapy and the development that has been reached in the immunophenotypic and mutatio...
"Focused Ultrasound-mediated Drug Delivery in Humans - a Path Towards Translation in Neurodegenerative Diseases" [0.03%]
“人类集中式超声药物输送——在神经退行性疾病中转化之路”
Joanna M Wasielewska,Anthony R White
Joanna M Wasielewska
The blood-brain barrier (BBB) has a major protective function in preventing the entry of harmful molecules into the brain, but is simultaneously limiting the delivery of drugs, restricting their potential clinical application in neurodegene...
Nisin ZP, an Antimicrobial Peptide, Induces Cell Death and Inhibits Non-Small Cell Lung Cancer (NSCLC) Progression in vitro in 2D and 3D Cell Culture [0.03%]
nisin ZP通过二维和三维细胞培养抑制非小细胞肺癌(NSCLC)进展并诱导细胞死亡
Suyash M Patil,Nitesh K Kunda
Suyash M Patil
Lung cancer is the leading cause of cancer deaths globally with most of the reported cases (> 85%) associated with non-small cell lung cancer (NSCLC). Current therapies have enhanced the overall survival rate of patients but treatment-relat...
Minimal Physiologically-based Pharmacokinetic Model to Investigate the Effect of Charge on the Pharmacokinetics of Humanized anti-HCV-E2 IgG Antibodies in Sprague-Dawley Rats [0.03%]
基于生理学的最小药代动力学模型研究荷人源抗HCV-E2 IgG单克隆抗体电荷对大鼠体内药代动力学的影响
Deni Hardiansyah,Chee Meng Ng
Deni Hardiansyah
Purpose: To develop a minimal physiologically-based pharmacokinetic (mPBPK) model in quantifying the relationships between the charge and pharmacokinetics (PK) of therapeutic monoclonal IgG antibody (TMAb). ...
In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals [0.03%]
健康和中风动物的体内和体外脑摄取研究肽模仿神经蛋白酶激活剂
Saeideh Nozohouri,Shiva Hadi Esfahani,Behnam Noorani et al.
Saeideh Nozohouri et al.
Purpose: Neurolysin (Nln) is a peptidase that functions to preserve the brain following ischemic stroke by hydrolyzing various neuropeptides. Nln activation has emerged as an attractive drug discovery target for treatment...