In Silico Development of Combinatorial Therapeutic Approaches Targeting Key Signaling Pathways in Metabolic Syndrome [0.03%]
针对代谢综合征关键信号通路的组合治疗策略的计算机辅助开发研究进展
Maksim Khotimchenko,Nicholas E Brunk,Mark S Hixon et al.
Maksim Khotimchenko et al.
Purpose: Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provok...
Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling [0.03%]
基于蛋白质组学的生理药代动力学(PBPK)模型探究乙胺丁醇的眼毒性机制
Ankit Balhara,Mayur K Ladumor,Rakesh P Nankar et al.
Ankit Balhara et al.
Purpose: Ethambutol (EMB) is a first-line anti-tubercular drug that is known to cause optic neuropathy. The exact mechanism of its eye toxicity is unknown; however, proposition is metal chelating effect of both EMB and it...
Chenguang Wang,Changquan Calvin Sun
Chenguang Wang
Purpose: Water of crystallization has been observed to increase plasticity, decrease crystal hardness, and improve powder compressibility and tabletability of organic crystals. This work is aimed at gaining a molecular le...
Direct Cytosolic Delivery of Proteins Using Lyophilized and Reconstituted Polymer-Protein Assemblies [0.03%]
用于递送蛋白质的冷冻干燥和重组聚合物-蛋白复合物
David C Luther,Harini Nagaraj,Ritabrita Goswami et al.
David C Luther et al.
Purpose: Cytosolic delivery of proteins accesses intracellular targets for chemotherapy and immunomodulation. Current delivery systems utilize inefficient endosomal pathways of uptake and escape that lead to degradation o...
Translational Modeling Identifies Synergy between Nanoparticle-Delivered miRNA-22 and Standard-of-Care Drugs in Triple-Negative Breast Cancer [0.03%]
翻译模型鉴定出纳米颗粒递送的miRNA-22与三阴性乳腺癌标准疗法药物之间的协同作用
Prashant Dogra,Javier Ruiz Ramírez,Joseph D Butner et al.
Prashant Dogra et al.
Purpose: Downregulation of miRNA-22 in triple-negative breast cancer (TNBC) is associated with upregulation of eukaryotic elongation 2 factor kinase (eEF2K) protein, which regulates tumor growth, chemoresistance, and tumo...
To Measure is to Know: A Perspective on the Work of Dr. Margareta Hammarlund-Udenaes [0.03%]
衡量即认知：Hammarlund-Udenaes博士工作的视角
Jessica I Griffith,William F Elmquist
Jessica I Griffith
Huiping Tu,Kevin Carrick,Rebecca Potts et al.
Huiping Tu et al.
Purpose: Erythropoietin (EPO) is a 165 amino acid protein that promotes the proliferation of erythrocytic progenitors. A decrease in endogenous EPO production causes anemia that can be treated with recombinant Human EPO (...
Consideration of Fractional Distribution Parameter fd in the Chen and Gross Method for Tissue-to-Plasma Partition Coefficients: Comparison of Several Methods [0.03%]
Chen-Gross法中组织/血浆分配系数计算的分数分布参数fd考量：几种方法比较
Yoo-Seong Jeong,William J Jusko
Yoo-Seong Jeong
Purpose: The tissue-to-plasma partition coefficient (Kp) describes the extent of tissue distribution in physiologically-based pharmacokinetic (PBPK) models. Constant-rate infusion studies are common for experimental deter...
In Vitro-In Vivo Correlation of Blood-Brain Barrier Permeability of Drugs: A Feasibility Study Towards Development of Prediction Methods for Brain Drug Concentration in Humans [0.03%]
关于药物血脑屏障通透性的体内外相关性：开发预测人体脑内药浓度方法的可行性研究
Ryo Ito,Hanae Morio,Tomoyo Baba et al.
Ryo Ito et al.
Purpose: In vitro human blood-brain barrier (BBB) models in combination with central nervous system-physiologically based pharmacokinetic (CNS-PBPK) modeling, hereafter referred to as the "BBB/PBPK" method, are expected t...
A Mechanistic Understanding of Monoclonal Antibody Interfacial Protection by Hydrolytically Degraded Polysorbate 20 and 80 under IV Bag Conditions [0.03%]
聚山梨酯20和80水解降解物通过界面保护作用对单克隆抗体稳定性影响的机理研究
Aadithya Kannan,Jamie Giddings,Shrenik Mehta et al.
Aadithya Kannan et al.
Purpose: Polysorbates (PS) contain polyoxyethylene (POE) sorbitan/isosorbide fatty acid esters that can partially hydrolyze over time in liquid drug products to generate degradants and a remaining intact PS fraction with ...