Weiping Zeng,Zhengbo Wen,Honglin Chen et al.
Weiping Zeng et al.
Exosomes are extracellular vesicles secreted by cells with a particle size of 30-150 nm in diameter. Exosomes can be used as natural drug carriers. The treatment of cancer with drug-loaded exosomes is an area of high interest. This review i...
Ritonavir-Boosted Exposure of Kinase Inhibitors: an Open Label, Cross-over Pharmacokinetic Proof-of-Concept Trial with Erlotinib [0.03%]
一种针对激酶抑制剂的达芦那韦增效暴露：一项开放性、交叉药代动力学概念验证试验，以厄洛替尼为例
René J Boosman,Cornedine J de Gooijer,Stefanie L Groenland et al.
René J Boosman et al.
Background: Although kinase inhibitors (KIs) are generally effective, their use has a large impact on the current health care budget. Dosing strategies to reduce treatment costs are warranted. Boosting pharmacokinetic exp...
Evaluation of Two Cosolvency Models to Predict Solute Partitioning between Polymers (LDPE) and Water - Ethanol Simulating Solvent Mixtures [0.03%]
评估两种共溶剂模型以预测聚合物（LDPE）和水-乙醇模拟溶剂混合物之间的溶质分布性能
Thomas Egert,Horst-Christian Langowski
Thomas Egert
Purpose: Binary water - ethanol mixtures, by mimicking a clinically relevant medium's polarity-driven extraction strength, facilitate experimental modeling of patient exposure to chemicals which can potentially leach from...
Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers [0.03%]
RO7304898（由两种迅速互变异构的非对映异构体组成的活性药物成分）的化学、分析和药代动力学性质研究
Katja Heinig,Filippo Sladojevich,Jeannine Petrig Schaffland et al.
Katja Heinig et al.
Purpose: Exploration of the chemical, analytical and pharmacokinetic properties of the API, RO7304898, an allosteric EGFR inhibitor, intended to be developed as a mixture of two rapidly interconverting diastereoisomers wi...
PAMAM versus PEI complexation for siRNA delivery: interaction with model lipid membranes and cellular uptake [0.03%]
PAMAM与PEI的siRNA传递复合物：模型脂质膜相互作用及细胞摄取
Patrick K C Chang,Clive A Prestidge,Kristen E Bremmell
Patrick K C Chang
Purpose: Cationic polymers have many advantages as vectors for mediated cellular entry and delivery of siRNA. However, toxicity related to their cationic charge has compromised clinical use. It is hypothesized that the si...
Correction: In Vitro-In Vivo Extrapolation of Hepatic Clearance in Preclinical Species [0.03%]
关于肝清除率的体外-体内类推在临床前物种中的纠正意见
David A Tess,Sangwoo Ryu,Li Di
David A Tess
Published Erratum
Pharmaceutical research. 2022 Jul;39(7):1659. DOI:10.1007/s11095-022-03233-x 2022
Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening [0.03%]
靶向siRNA筛选技术鉴定位於血脑屏障模型细胞系hCMEC/D3中的Aripiprazole摄取转运体
Moeno Kadoguchi,Hiroshi Arakawa,Ryokichi Honda et al.
Moeno Kadoguchi et al.
Aim: Identification of blood-brain barrier (BBB) uptake transporters is a major challenge in the research and development of central nervous system (CNS) drugs. However, conventional methods that consider known drug uptak...
Freeze-Dried Biopharmaceutical Formulations are Surprisingly Less Stable than Liquid Formulations during Dropping [0.03%]
冻干生物药物配方在跌落过程中比液体配方更不稳定
Wei-Jie Fang,Meng-Juan Pang,Jia-Wei Liu et al.
Wei-Jie Fang et al.
Purposes: This article describes an interesting phenomenon in which optimized freeze-dried (FD) biopharmaceutical formulations are generally more prone to degradation than their liquid counterparts during dropping and pro...
Effect of Particle Size and Surface Charge on Nanoparticles Diffusion in the Brain White Matter [0.03%]
粒径和表面电荷对纳米颗粒在脑白质中扩散的影响
Tian Yuan,Ling Gao,Wenbo Zhan et al.
Tian Yuan et al.
Purpose: Brain disorders have become a serious problem for healthcare worldwide. Nanoparticle-based drugs are one of the emerging therapies and have shown great promise to treat brain diseases. Modifications on particle s...
Ernest Man,Helen P Price,Clare Hoskins
Ernest Man
Cutaneous parasites are identified by their specific cutaneous symptoms which are elicited based on the parasite's interactions with the host. Standard anti-parasitic treatments primarily focus on the use of specific drugs to disrupt the re...