Multicomponent Droplet Drying Modeling Based on Conservation and Population Balance Equations [0.03%]
基于守恒和群体平衡方程的多组分液滴干燥模型研究
Sadegh Poozesh,Faisal Algasem,Mohammad A Azad et al.
Sadegh Poozesh et al.
The aim of this work is to present a modeling tool to describe drying kinetics and delineate evolving physical and chemical behavior of multicomponent droplets during drying. Conservation equations coupled with population balance equations ...
A Novel Faster-Acting, Dry Powder-Based, Naloxone Intranasal Formulation for Opioid Overdose [0.03%]
一种新型的速效鼻用纳洛酮干燥粉剂制剂用于阿片类药物过量中毒救治
Tair Lapidot,Mohammed Bouhajib,Janice Faulknor et al.
Tair Lapidot et al.
Objective: To examine the pharmacokinetics and safety of FMXIN001, a new intranasal powder-based naloxone formulation, in comparison to Narcan® nasal liquid spray. ...
Randomized Controlled Trial
Pharmaceutical research. 2022 May;39(5):963-975. DOI:10.1007/s11095-022-03247-5 2022
Recent Update on Bacteria as a Delivery Carrier in Cancer Therapy: From Evil to Allies [0.03%]
细菌作为载体在癌症治疗中的最新研究进展：从恶魔到盟友
Manisha Pandey,Hira Choudhury,Prathiba A/P Vijayagomaran et al.
Manisha Pandey et al.
Cancer is associated with a comprehensive burden that significantly affects patient's quality of life. Even though patients' disease condition is improving following conventional therapies, researchers are studying alternative tools that ca...
Inhibition of Insulin Degrading Enzyme to Control Diabetes Mellitus and its Applications on some Other Chronic Disease: a Critical Review [0.03%]
胰岛素降解酶抑制剂控制糖尿病及其对某些慢性病的潜在应用：综述性批判文章
Md Shofiul Azam,Md Wahiduzzaman,Md Reyad-Ul-Ferdous et al.
Md Shofiul Azam et al.
Purpose: This review aims to provide a precise perceptive of the insulin-degrading enzyme (IDE) and its relationship to type 2 diabetes (T2D), Alzheimer's disease (AD), obesity, and cardiovascular diseases. The purpose of...
Re-writing Oral Pharmacokinetics Using Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models [0.03%]
基于生理的有限时间药动学(PBFTPK)模型在口腔药物代谢动力学中的应用
Pavlos Chryssafidis,Athanasios A Tsekouras,Panos Macheras
Pavlos Chryssafidis
Purpose: To develop physiologically based finite time pharmacokinetic (PBFTPK) models for the analysis of oral pharmacokinetic data. Methods: ...
Spray Dried Rugose Lipid Particle Platform for Respiratory Drug Delivery [0.03%]
用于呼吸道药物递送的喷雾干燥粗糙脂质颗粒平台
Hui Wang,Mani Ordoubadi,Patrick Connaughton et al.
Hui Wang et al.
Purpose: To develop a new lipid-based particle formulation platform for respiratory drug delivery applications. To find processing conditions for high surface rugosity and manufacturability. To assess the applicability of...
Targeting Transporters for Drug Delivery to the Brain: Can We Do Better? [0.03%]
更有效的药物输送策略：能否更好地针对转运蛋白来将药物送入大脑？
Elena Puris,Gert Fricker,Mikko Gynther
Elena Puris
Limited drug delivery to the brain is one of the major reasons for high failure rates of central nervous system (CNS) drug candidates. The blood-brain barrier (BBB) with its tight junctions, membrane transporters, receptors and metabolizing...
Novel Deep Eutectic Solvent-Hydrogel Systems for Synergistic Transdermal Delivery of Chinese Herb Medicine and Local Treatments for Rheumatoid Arthritis [0.03%]
用于中草药经皮递送及类风湿性关节炎局部治疗的新型深吴溶剂-水凝胶系统
Suyun Xiao,Liyun Wang,Wei Han et al.
Suyun Xiao et al.
In this study, a novel hydrogel system incorporating an amino acid-based deep eutectic solvent (DES) was prepared, and the skin-permeation enhancement of traditional Chinese herb medicine was evaluated using "sanwujiaowan" extract as the mo...
A Charge Variant of Bevacizumab Offers Enhanced FcRn-Dependent Pharmacokinetic Half-Life and Efficacy [0.03%]
带有电荷变异的贝伐单抗增强了FcRn依赖性药代动力学半衰期和疗效
Sumit K Singh,Deepak Kumar,Saurabh Nagpal et al.
Sumit K Singh et al.
Background: Lysine variants of monoclonal antibodies (mAbs) result from incomplete clipping of the C-terminal lysine residues of the heavy chain. Although the structure of the lysine variants has been determined for sever...
Converting Tretinoin into Ionic Liquids for Improving Aqueous Solubility and Permeability across Skin [0.03%]
将维甲酸转化成离子液体以提高其在水中的溶解度及经皮渗透能力
Xiying Wu,Jingjing Xuan,Qin Yu et al.
Xiying Wu et al.
Purpose: The aim of this study is to convert tretinoin (Tr), an active pharmaceutical ingredient (API), into ionic liquid for improving aqueous solubility and permeability of Tr in transdermal drug delivery applications. ...