Active Targeting of Colorectal Cancer Using Chemotherapy-Loaded Nanoparticles Functionalized with a Folate Receptor-α (FRα) Ligand, Pemetrexed [0.03%]
使用加载了培美曲塞的叶酸受体α（FRα）配体功能化纳米颗粒进行靶向结直肠癌化疗
Mohammad Alnatour,Ramkrishna Sen,Leela Sai Lokesh Janardhanam et al.
Mohammad Alnatour et al.
Purpose: Colorectal cancer (CRC) is a leading cause of cancer mortality with current chemotherapeutic strategies often limited by systemic side effects and suboptimal tumor targeting. This study aimed to enhance the deliv...
A Tale of Two Stressors in Biologic Drug Product Development: Shaking Mode and Primary Packaging [0.03%]
生物制剂开发中的两种应激因素：摇摆模式和主要包装容器的影响故事
Siddhanth Hejmady,Elham Taherian,Reza Nejadnik
Siddhanth Hejmady
Purpose: Mechanical, interfacial, and shear stresses encountered during development, manufacturing and transportation of biologics can compromise monoclonal antibody (mAb) stability. However, most scale-down shaking model...
Next Generation 3D Printed Multipurpose Intravaginal Ring For Sustained Co-Delivery of Antiretroviral Drugs and A Contraceptive Hormone [0.03%]
用于长效联合递送抗逆转录病毒药物和避孕激素的下一代3D打印多功能宫内节育器
Denali K Dahl,Rima Janusziewicz,Roopali Shrivastava et al.
Denali K Dahl et al.
Objective: Globally, a significant overlap exists between females affected by HIV and HSV-2 infections, and who have an unmet need for contraception. Intravaginal rings (IVRs) have become widely accepted by women worldwid...
Exploration of 2-Mercaptoquinazolin-4(3H)-one Based N-Hydroxyheptanamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Anticancer Bioevaluation [0.03%]
基于2-甲硫基喹唑啉-4(3h)-酮的n-羟基庚酰胺类组蛋白去乙酰化酶抑制剂的设计、合成及抗肿瘤活性研究
Le Thi Thao,Hwa Kyung Kim,Hoang Kim Ngoc et al.
Le Thi Thao et al.
Objective: Histone deacetylase (HDAC) inhibitors have emerged as promising cancer therapeutics by regulating gene expression, halting cell cycle progression, and inducing apoptosis. This study explores the structure-activ...
Development and Optimization of Myricetin Loaded Inhalable Microsphere to Treat COPD [0.03%]
一种用于治疗慢性阻塞性肺疾病的杨梅素吸入微球的开发与优化研究
Suhas Shivaji Siddheshwar,Darshana Jagtap,Someshwar Dattatraya Mankar et al.
Suhas Shivaji Siddheshwar et al.
Objectives: To develop and optimize myricetin-loaded inhalable microspheres using ionotropic gelation technique for sustained pulmonary delivery in Chronic Obstructive Pulmonary Disease (COPD) treatment. ...
Silver Nanoclay Human Albumin Serum Composite Electrochemical Biosensor for Quantification of Zidovudine in Tablets [0.03%]
银纳米粘土人血清白蛋白复合电化学生物传感器定量测定片剂中的叠氮脱氧胸苷
Sapokazi Timakwe,Mangaka C Matoetoe
Sapokazi Timakwe
Objective: This work aims to develop an electrochemical biosensor for the analysis of zidovudine (ZDV) in commercial tablets. Method: T...
Natural Powerhouse Duo: Hierarchical Levan Hydrogels with Nanoencapsulated Cannabidiol as Local Delivery Systems [0.03%]
天然 powerhouse duo：作为局部输送系统的分层葡聚糖水凝胶，含有纳米胶囊大麻二酚
Diana Solovyov,Natalia N Porfiryeva,Rania Awad et al.
Diana Solovyov et al.
Introduction: The nonpsychoactive cannabinoid cannabidiol (CBD) has shown a wide range of pharmacological effects that are beneficial for wound healing. However, its local delivery is challenged by a very low aqueous solu...
A Comprehensive Design-to-skin Pipeline to Fabricate Polymeric Microneedles Using Ultrahigh-resolution 3D Printing [0.03%]
一种基于超高分辨率3D打印的用于制造聚合物微针的一站式制备方法
Francesco La Malfa,Isabella A van Hulst,Ferry Ossendorp et al.
Francesco La Malfa et al.
Objective: Microneedle technologies have emerged as a promising approach to improve intradermal drug delivery. This study presents a comprehensive workflow for fabricating polymeric microneedle arrays utilising ultrahigh-...
Retraction Note: MicroRNA-302 Replacement Therapy Sensitizes Breast Cancer Cells to Ionizing Radiation [0.03%]
撤回 notice:MicroRNA-302 替换疗法使乳腺癌细胞对电离辐射敏感
Zhongxing Liang,Jeffrey Ahn,Donna Guo et al.
Zhongxing Liang et al.
Using Lung Regional Deposition Modeling as Model-Integrated Evidence for Locally Acting Orally Inhaled Drug Products [0.03%]
基于模型的证据在局部作用口服吸入制剂中的应用——肺部区域沉积模型的应用
Ross L Walenga,Steven G Chopski,Jae H Lee et al.
Ross L Walenga et al.
Evaluation of drug delivery for locally acting orally inhaled drug products (OIDPs) is challenging because there are no routinely conducted studies that directly quantify drug concentration in specific regions of the human lungs. In vivo re...