The Use of Digital Image Processing in the Modelling of a Roller Compaction Milling Operation [0.03%]
数字图像处理在辊压机建模中的应用研究进展
David Wilson,Alexa Mesham,Felix Tim Bölle
David Wilson
Purpose: Granulation by roller compaction is an important unit operation in the production of pharmaceutical oral solid dosages. This process involves producing a densified "ribbon" of compressed powder between two counte...
The Role of Cyclodextrins in Modulating Stimuli-Responsiveness for Anticancer Drug Delivery [0.03%]
环糊精在调节抗癌药物递送刺激响应性中的作用
Andrea Cesari,Liu Zhengming,Fabio Bellina
Andrea Cesari
Background: The precision delivery of active pharmaceutical ingredients remains a major challenge in modern pharmacology, where conventional therapies often lack selectivity and cause severe side effects. Stimuli-responsi...
The Impact of Particle Properties on High Concentration Suspension Performance and Stability of Spray-Dried Monoclonal Antibodies [0.03%]
颗粒属性对高浓度喷雾干燥单克隆抗体稳定性的影响分析
Yijing Huang,Jiaying Liu,Ruomeng Qiu et al.
Yijing Huang et al.
Objective: Subcutaneous (subQ) administration of biologic drug products is increasingly preferred to enable patient self-administration and reduce healthcare burden. However, the small dosing volume for subQ delivery nece...
The Versatile Role of GDF5 in Chondrogenic Progenitor Cell-mediated Cartilage Regeneration via a Hyaluronic Acid-fibrin IPN Hydrogel Platform [0.03%]
GDF5在透明质酸-纤维蛋白IPN水凝胶平台介导的软骨祖细胞活化及软骨再生中的多功能作用研究
Rui He,Venkateswaran Ganesh,Pornpoj Phruttiwanichakun et al.
Rui He et al.
Objective: Focal damage to articular cartilage incurred during joint injuries frequently progresses to post-traumatic osteoarthritis (PTOA) due to the limited intrinsic repair capacity of cartilage. Chondrogenic progenito...
Correction: Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells [0.03%]
乌索酸及其类似物对雄性F344大鼠结肠癌变的化学预防作用及在人结肠HT-29肿瘤细胞中的COX-2和凋亡调节作用的修正文章
Naveena B Janakiram,Cooma Indranie,Swamy V Malisetty et al.
Naveena B Janakiram et al.
Published Erratum
Pharmaceutical research. 2026 Apr 9. DOI:10.1007/s11095-026-04090-8 2026
Effects of Airway Generation Depth on Particle Deposition Behaviour in the Main Respiratory Airways-A Computational Modelling Study [0.03%]
气道生成深度对主要呼吸道颗粒沉积行为的影响-一种计算模型研究
Xinyu Cai,Damien Chong,Hui Xin Ong et al.
Xinyu Cai et al.
Purpose: Effective inhaled drug delivery depends on formulation, device, and a clear understanding of aerosol transport in the respiratory tract. This study explores how lower airway anatomical complexity affects airflow ...
An Innovative Multifaceted Approach to Enhance the Sensitivity of a Target Engagement ELISA [0.03%]
一种创新的多面方法以增强靶点参与ELISA的灵敏度
Nahong Qiu,Alexandra Nitsche,Isabelle Beley et al.
Nahong Qiu et al.
Target engagement (TE) assessments often come with bioanalytical challenges, particularly with low baseline level targets like cytokines and chemokines. Commercial immunoassay kits often cannot meet the requirements of sensitivity and drug ...
In vitro and ex vivo Pharmacological Profile of HY-022619, a Novel Intravenous P2Y12 Receptor Antagonist with Rapid-onset and Sustained Antiplatelet Activity [0.03%]
HY-022619是一种新型的静脉注射P2Y12受体拮抗剂，具有快速起效和持久的抗血小板作用：体外和离体药理特征
Jiajia Mo,Emily M He,Yan Zhao et al.
Jiajia Mo et al.
Purpose: Patients with acute coronary syndrome (ACS) require rapid and potent antiplatelet therapy during percutaneous coronary intervention (PCI). Current first-line P2Y₁₂ inhibitors are limited by delayed efficacy or ...
Regulatory Roles of Long Non-Coding RNAs in Methotrexate Pharmacology: Mechanistic and Translational Insights [0.03%]
长非编码RNA在甲氨蝶呤药理学中的调控作用：机制和转化见解
Carlos A Guzmán-Martín,Nadia Janet González-Moyotl,Yaneli Juárez-Vicuña et al.
Carlos A Guzmán-Martín et al.
Background: Methotrexate (MTX) remains a cornerstone therapy in autoimmune diseases and oncology; however, substantial interindividual variability in efficacy and toxicity persists. While variability in MTX pharmacokineti...
Development of a Novel Curcumin-Vanillic Acid Eutectic: Physicochemical Characterization, Antioxidant Activity, and Bioavailability Enhancement [0.03%]
一种新型姜黄素-香草酸共熔物的开发：理化性质、抗氧化活性及生物利用度增强效应
Jidnyasa Pantwalawalkar,Namdeo Jadhav,Sopan Nangare
Jidnyasa Pantwalawalkar
Objective: Curcumin, a well-known phyto-nutraceutical with broad therapeutic potential, faces critical formulation challenges, including poor aqueous solubility, low dissolution rate, and limited tablettability, leading t...