A Cell-Based Reporter Gene Assay for TNF-α Neutralization: Analytical Qualification and Application to Adalimumab and Its Biosimilars [0.03%]
一种基于细胞的TNF-α中和反应报告基因测定法：分析资质鉴定及阿达木单抗及其类似物的应用研究
Christelle Anne F Ancajas,Shen Luo,Baolin Zhang
Christelle Anne F Ancajas
Purpose: To qualify a mechanism-of-action (MoA)-reflective reporter gene assay (RGA) for measuring the biological activity of adalimumab (Humira) and its biosimilars, supporting assessment of product quality, comparabilit...
PK-PD Modeling Suggests Tumor Heterogeneity Limits Preclinical to Clinical Translation of Enzalutamide in Prostate Cancer [0.03%]
PKPD模型提示肿瘤异质性限制了恩杂鲁胺在前列腺癌的临床前到临床转化
Se Jin Kim,Robert Bies,Donald E Mager
Se Jin Kim
Purpose: To assess the translational performance of preclinical models to anticipate enzalutamide clinical efficacy in prostate cancer using a cross-species physiologically-based pharmacokinetic (PBPK)-pharmacodynamic (PD...
Cutaneous Bioavailability of Corticosteroids from Topical Formulations: a Retrospective Analysis of Data from In Vitro Permeation Testing (IVPT) and In Vivo Assessments [0.03%]
皮质类固醇药膏中活性药物成分的经皮吸收：来自体外透皮试验和体内评估的数据的回顾性分析
Paul A Lehman,Thomas J Franz
Paul A Lehman
Background: The In Vitro Permeation Test (IVPT) is a valuable tool for the study of topical pharmacokinetics of dermatologic formulations. A 45 year retrospective analysis was performed on archived percutaneous absorption...
CFD Modeling of Airflow and Aerosol Transport in the Human Respiratory System: A Comprehensive Review [0.03%]
人体呼吸系统中气流和气溶胶输运的计算流体力学建模综述研究
Dogan Ciloglu,Hacer Ucuncu
Dogan Ciloglu
Background: Accurate modelling of airflow and aerosol/particle dynamics within the human respiratory system is essential for improving inhalation-based drug delivery strategies and for evaluating the health risks associat...
Nano-DSF Technology as a Preliminary Decision-Making Tool for Long Term Stability Evaluation of Covid-19 Vaccine Antigens [0.03%]
纳米差示扫描量热法技术作为新冠疫苗抗原长期稳定性评价的初步决策工具
Rahul Misra,Siddhant Sharma,Manjit Haer et al.
Rahul Misra et al.
Purpose: Nano differential scanning fluorimetry (nano-DSF) is a high-throughput screening technique that simultaneously assesses colloidal and conformational stabilities of protein antigens by monitoring their thermal unf...
Microdermabrasion with Calcium Hydrogen Phosphate for Enhancing Skin Permeation of Lidocaine-tetracaine Eutectic Microemulsion Gel [0.03%]
应用磷酸二氢钙微晶磨削促进利多卡因-四甲基苯并卡aine共熔凝胶透皮吸收的研究
Ying Chen,Yuye Yang,Jin Su et al.
Ying Chen et al.
Background: Transdermal drug delivery (TDD) offers a convenient administration for treating local or systemic diseases. However, the dense "brick-mortar" structure of the stratum corneum hinders the skin permeation of mos...
Pharmaceutical Stability of Romiplostim: In-use Functional Study Using Microscale Thermophoresis New Strategy and Elisa [0.03%]
罗米司亭药物稳定性：使用微尺度热致穿流新技术和酶联免疫吸附法的在用功能性研究
Jesús Hermosilla,Salvador Casares-Atienza,Julio Ruiz-Travé et al.
Jesús Hermosilla et al.
Objective: Functional stability is crucial for therapeutic proteins at all stages of their lifecycle. Romiplostim (Nplate®) is world-wide used for treating immune thrombocytopenia purpura. Limited in-use stability data o...
Mucolytic Core-Shell Particles to Boost Levofloxacin Penetration Through the Mucus Barrier in Cystic Fibrosis [0.03%]
用于增强左氧氟沙星穿透囊性纤维化黏液屏障的溶粘核壳颗粒
Valentina Ruggiero,Francesca Mariano,Domenico Larobina et al.
Valentina Ruggiero et al.
Purpose: The purpose of this study was to investigate multi-fluid spray drying as a formulation strategy to engineer inhalable microparticles containing levofloxacin and mucolytic agents, and to evaluate how formulation a...
Recent Progress in Exosome-Derived Nanocarriers for Breast Cancer Therapy: Advances, Translational Barriers, and Scale-Up Considerations [0.03%]
乳腺癌治疗的外泌体衍生纳米载体最新进展：进展、转化障碍及放大生产考虑因素
Julie R Youssef,Esraa M Elgammal,Dina M Mahdy et al.
Julie R Youssef et al.
Breast cancer remains the most prevalent malignancy among women worldwide and a major cause of cancer-related mortality. Despite remarkable progress in molecularly targeted and immune-based therapies, therapeutic resistance, dose-limiting s...
Yutong Tian,Shihao Song,Yaojie Shi et al.
Yutong Tian et al.
Background: Titanium dioxide (TiO2) is widely used as a white additive in food and pharmaceuticals, but its safety has raised increasing concerns. Currently, calcium carbonate is commonly used as an alternative to TiO2 in...