Mechanistic Insight into Formation and Release Enhancement of Sulindac-Amino Acid Small-Molecule Hydrogels [0.03%]
硫磺香豆素-氨基酸小分子水凝胶形成机理及其促进释放研究
Jiaxin Chen,Huizhen Sun,Wuheng Yue et al.
Jiaxin Chen et al.
Purpose: As research on gels continues to advance, pharmaceutical small-molecule hydrogels have attracted growing interest in formulation development. This study addressed two key questions: whether small-molecule hydroge...
Immune Efficacy of a Vaccine Candidate Based on Binding Protein 26 (BP26) from Brucella melitensis Encapsulated in Niosome Nanoparticles Against Brucellosis [0.03%]
基于纳米颗粒包封的布鲁氏菌melitensis株结合蛋白26（BP26）亚单位疫苗候选株对布病免疫效力研究
Kimia Talebi,Mohsen Chiani,Mehri Habibi et al.
Kimia Talebi et al.
Purpose: Brucellosis is a common zoonosis, affecting animals and humans. Given the high prevalence of brucellosis, as well as the challenges associated with the animal vaccines, there is a need to develop effective vaccin...
Computational Design and Biopharmaceutical Evaluation of a Chimeric Nanoparticle Vaccine for Targeted Delivery against BK Polyomavirus [0.03%]
计算设计和生物药物评价针对BK多瘤病毒靶向递送的嵌合纳米颗粒疫苗
Amin Zahmatkesh,Seyed Nooreddin Faraji,Seyed Younes Hosseini et al.
Amin Zahmatkesh et al.
Purpose: To address the unmet need for a prophylactic therapy against BK polyomavirus (BKPV) in transplant recipients, this study employed a mechanism-based computational approach to design a multi-epitope chimeric nanopa...
Preparation of SP94-Modified Calcium Phosphate Lipid Nanoparticles Loaded with Bcl-2 siRNA and Doxorubicin and Their Targeted Therapeutic Effect on Hepatocellular Carcinoma [0.03%]
载Bcl-2小干扰核酸及阿霉素SP94修饰型钙磷酸脂质体纳米粒的制备及其对肝癌靶向治疗效果的研究
Kailun Ma,Jinfei Yao,Yueyi Deng et al.
Kailun Ma et al.
Purpose: To improve the targeted therapy of hepatocellular carcinoma (HCC), SP94-modified calcium phosphate lipid nanoparticles loaded with Bcl-2 siRNA and doxorubicin (SP94-LCP/DOX&Bcl-2 siRNA) were prepared. ...
Lateral Transport in Anisotropic Membrane during Permeation Study in Diffusion Cell [0.03%]
扩散池渗透过程中各向异性膜中的平行输运
Patcharawan Nimmansophon,S Kevin Li
Patcharawan Nimmansophon
Purpose: In membrane transport studies utilizing a diffusion cell such as In Vitro Permeation Test (IVPT), mass transport is not purely one-dimensional from the donor to the receptor. Lateral diffusion within the membrane...
Lithocholic Acid-Derived Imidazolium Salts Suppress Breast Cancer Growth: In Vitro and In Vivo Evaluation [0.03%]
石胆酸衍生物咪唑𬭩盐可通过体内和体外实验抑制乳腺癌生长
Diana Sawicka,Anna Sadowska,Agnieszka Hryniewicka et al.
Diana Sawicka et al.
Purpose: A series of imidazolium salts (IMS), substituted with lithocholic acid (LA) and alkyl chains of varying lengths (LA-1 to LA-10), were evaluated for their cytotoxic effects against breast cancer (BC). ...
Trichomonas vaginalis Drug Targets and Their Role in Drug Discovery and Development [0.03%]
阴道毛滴虫药物靶点及其在药物研发中的作用
Mirna Samara Dié Alves,Ângela Sena-Lopes,Luiza Domingues Moron et al.
Mirna Samara Dié Alves et al.
Trichomonas vaginalis is the causative agent of trichomoniasis, the most common and prevalent sexually transmitted infection (STI) globally, with about 156 million cases annually. Trichomoniasis is a critical public health problem, and it i...
Development of a Water-soluble Form of Umifenovir Through the Synergistic Action of a Surfactant and a Hydrotropic Agent: A Multifactorial Study [0.03%]
通过表面活性剂和氢键渗透剂的协同作用开发乌美酚水溶性形式：多因素研究
Tatyana V Volkova,Olga R Simonova,German L Perlovich
Tatyana V Volkova
Purpose: The aim of this study was to develop a water-soluble form of umifenovir (UMF) through the synergistic action of the non-ionic surfactant Brij35 and choline bitartrate (ChB), and to investigate the solubility, agg...
Thermally Stressed Solid-State Stability of Semaglutide: Understanding the Influence of Temperature on Protein Content, Secondary Structure, Phase Transition, and Chemical Degradation [0.03%]
司美格鲁肽固体状态下热应力稳定性研究：温度对蛋白质含量、二级结构、相变及化学降解的影响分析
Sideequl Akbar,Adarsh Malgave,Anumol Joseph et al.
Sideequl Akbar et al.
Objective: Semaglutide (SMG), a clinically relevant peptide-based therapeutic whose physical and chemical stability are critical concerns during manufacturing and storage. Although the stability of SMG in solution has bee...
Raman Imaging-based Analysis of Drug Powder Dissolution on Calu-3 Cell Monolayers as a Mechanistic Predictor of Nasal Absorption [0.03%]
基于拉曼成像的药物粉末在Calu-3单层细胞中溶解分析作为鼻吸收机制预测指标的方法
Tomoyuki Furubayashi,Akiko Tanaka,Ryosuke Tatsuta et al.
Tomoyuki Furubayashi et al.
Background: Intranasal powder formulations offer advantages in terms of stability and portability; however, their absorption is critically dependent on dissolution within the limited fluid volume of the nasal cavity. Conv...