Characterization of EpiIntestinal Duodenum Microtissue as an In Vitro Model for Studying Intestinal Drug Permeability, Transport, and Metabolism [0.03%]
体外小肠药物渗透、转运和代谢研究的类器官模型建立及特征分析方法学探索研究报告摘要公示公示公示
Jonathan Cheong,Jamie Jorski,Christopher Chhin et al.
Jonathan Cheong et al.
Purpose: The intestinal absorption of compounds administered orally can be impacted by permeability, metabolism and uptake/efflux transport. This study aimed to characterize the EpiIntestinal duodenum microtissue develope...
Integrative In-silico, Network Pharmacology, Pharmacogenomics and In-vitro Evaluation of Fulvestrant-Loaded Zinc Oxide Nanoparticles Targeting HER2 Positive Breast Cancer [0.03%]
氟维司群载锌氧化物纳米颗粒治疗HER2阳性乳腺癌的整合计算、网络药理学、药物基因组学和体外评价研究
Melphiya D,Krishnan Namboori P K,Jawahar N et al.
Melphiya D et al.
Background: HER2-positive breast cancer is characterized by the absence of estrogen and progesterone receptors and the overexpression of the HER2 receptor. Existing targeted therapies, leads to side effects like cardiotox...
Design, Development, and Characterization of a Tannic Acid-loaded Transfersomal Gel for Psoriatic Skin [0.03%]
一种用于银屑病皮肤的鞣酸转移体凝胶的设计、开发和表征
Mohammad Shaif,Poonam Kushwaha,Shazia Usmani et al.
Mohammad Shaif et al.
Background: Psoriasis is a chronic immune-mediated skin disorder marked by excessive keratinocyte proliferation, inflammation, and impaired barrier function, all of which limit effective topical drug delivery. ...
In Vitro Inhalation and Deposition of Salbutamol in Upper Airway Geometries [0.03%]
基于上呼吸道几何模型的沙丁胺醇体外吸入与沉积研究
Brenda Vara Almirall,Chun Yuen Jerry Wong,Philip Pille et al.
Brenda Vara Almirall et al.
Purpose: Accurate prediction of aerosol deposition in the extrathoracic airway is critical for designing inhaled therapies, yet many experimental and computational studies rely on geometries that are either simplified or ...
Investigation of Renal Tissue Deposition of the Calcineurin Inhibitors Voclosporin, Cyclosporine and Tacrolimus Using MALDI-MSI Imaging [0.03%]
应用MALDI-MSI成像技术研究环孢素和他克莫司类钙调磷酸酶抑制剂在肾组织中的沉积分布
Simon Zhou,Krishani Kumari Rajanayake,Miao He et al.
Simon Zhou et al.
Background: Calcineurin inhibitors (CNIs) are immunosuppressive agents that inhibit calcineurin (CN) and are recommended for the treatment of lupus nephritis (LN). In clinical trials, differences in the safety profiles of...
Pharmaceutical Roots to Mitochondrial Routes: Targeting Neurodegeneration [0.03%]
从药用根到线粒体途径：靶向神经退行性疾病
Abhilasha Sood,Arpit Mehrotra
Abhilasha Sood
Background: Mitochondria besides being the powerhouse of the cell are also involved in performing a multitude of critical cellular functions. Any failure in maintenance of these organelles is implicated in multiple human ...
Transcutaneous Delivery of Dual-Approach Oxaprozin and Apricot Kernel Oil Through a QbD Driven Nanoemulgel: Therapeutic Potential Against Osteoarthritis-Induced Animal Model [0.03%]
通过QbD驱动的纳米乳凝胶递送双通道奥沙普秦和杏仁油的透皮给药：针对骨关节炎诱导动物模型的治疗潜力
Ahsan Ali,Uzma Farooq,Ayesha Siddiqui et al.
Ahsan Ali et al.
Purpose: Osteoarthritis is a degenerative joint disease that causes painful inflammation with cartilaginous damage that highly impacts geriatric health, demanding advanced therapy with limited complications on treatment. ...
Polymorphism Control of Carbamazepine Based on Deep Eutectic Solvents [0.03%]
基于深 eutectic 溶剂的卡马西平多晶型调控
Xian Sun,Shuai Yu,Chunmei Lv et al.
Xian Sun et al.
Objectives: Carbamazepine (CBZ) is a drug that exists in multiple crystal forms and hydrates. In this study, CBZ was used as the model drug, and an attempt was made to regulate the crystal form and morphology of the drug ...
Chanakya D Patil,Yijing Huang,Kinnari Santosh Arte et al.
Chanakya D Patil et al.
Purpose: Drying is widely used to enhance the storage stability of biologic drug products which are susceptible to degradation in aqueous solutions. Compared to conventional freeze-drying, spray drying offers continuous, ...
Advanced in Co-Delivery, Controllable Therapy using Microneedle: From Design to Therapeutic Effects [0.03%]
微针复合给药与可控治疗研究进展：从设计到疗效分析
Phuong-Trang Nguyen-Thi,Nhat Thang Thi Nguyen,Huong Thuy Le et al.
Phuong-Trang Nguyen-Thi et al.
Microneedles (MNs) provide a minimally invasive and efficient platform for transdermal drug delivery, offering precise control over dosage and release kinetics. Recent advances in dual-drug delivery using dissolvable MNs have focused on opt...