Binding Kinetics Can Explain Linear and Nonlinear Pharmacokinetics of Dipeptidyl Peptidase-IV Inhibitors Within a Single Target-Mediated Framework [0.03%]
结合动力学可以解释二肽基肽酶-IV抑制剂的线性和非线性药代动力学在一个单一的目标介导框架内
Adam Elalem,Mfonabasi E Ette,Donald E Mager
Adam Elalem
Introduction: Dipeptidyl peptidase-IV inhibitors (DPP4i) are a class of small-molecule drugs for the treatment of patients with type 2 diabetes mellitus. Despite their common mechanism of action, the pharmacokinetics (PK)...
Evaluation of Mass Spectrometry Compatible Reagents for Determining Small Molecule Loading in Poly(lactic acid) Nanoparticles [0.03%]
用于测定聚乳酸纳米颗粒中微量小分子负载的与质谱兼容的试剂的评价
Samuel A Krug,Andrea L Cottingham,Masahiro Iwamoto et al.
Samuel A Krug et al.
Objective: The objective was to understand if sufficient base hydrolysis and subsequent small molecule quantitation within poly(lactic acid) nanoparticles (PLA-NPs) could be achieved using a mass spectrometry friendly vol...
Regional Nasal Drug Deposition in Pediatric vs. Adult Models: In vitro Insights into User Technique and Breathing Patterns Sensitivity [0.03%]
儿科与成人模型的区域性鼻内给药沉积情况：用户操作技术及呼吸模式敏感性的体外研究见解
Mohammad Hejazi,Xiomara Owen,David J Edwards et al.
Mohammad Hejazi et al.
Purpose: Although in vitro studies recommended for establishing bioequivalence of locally acting nasal suspension products provide useful information regarding product performance, currently they are not designed to fully...
Hannah R Weiler,Lauren M Le,Hala M Fadda
Hannah R Weiler
Purpose: Pediatric global regulatory initiatives have come into place to address gaps in evidence-based medicine for children. Objective of this study was to assess age-appropriateness of oral pediatric formulations autho...
Impact of Postnatal Changes in Creatinine Levels on Plasma Gentamicin Concentrations in Neonates [0.03%]
新生儿肌酐水平产后变化对血浆庆大霉素浓度的影响
Haruka Tsushita,Ryota Tanaka,Masanori Inoue et al.
Haruka Tsushita et al.
Objective: Gentamicin (GM), a renally eliminated drug, is widely used to treat infections in neonates. Neonatal dosing is typically based on body weight and postmenstrual age (PMA). Although serum creatinine (Cr) is the g...
Advancing Sterilization of Medical Implant Polymers: Novel Low-Temperature Deep-vacuum Vaporized H2O2 Technology Surpasses Current Methods [0.03%]
医疗器械植入用高分子材料的新型低温真空等离子灭菌技术及应用研究进展
Abinaya Nallathambi,Enrica Chiesa,Mariella Rosalia et al.
Abinaya Nallathambi et al.
Purpose: To develop a deep vacuum vaporized hydrogen peroxide (VH₂O₂) sterilization method capable of preserving the structural and functional integrity of biocompatible polymeric electrospun mats usable as advanced bio...
Advances and Further Comparison of Software Tools for Fisher Information Matrix-Based Design Evaluation in Pharmacometrics [0.03%]
基于Fisher信息矩阵的药代动力学设计评估软件工具的发展及其进一步比较研究
Lucie Fayette,Karl Brendel,France Mentré
Lucie Fayette
Aim: Before conducting a clinical study involving pharmacometrics analyses using Non-Linear Mixed Effects Models (NLMEM), study design can be evaluated by computing the Fisher Information Matrix (FIM) via first-order mode...
Evaluation of sNfL as a Biomarker for Paclitaxel-Induced Peripheral Neurotoxicity Through an Integrated PKPD Model [0.03%]
通过整合PKPD模型评估sNfL作为紫杉醇诱导的外周神经毒性的生物标志物的价值
Eman I K Ibrahim,Milda Girdenyté,Yang Hu et al.
Eman I K Ibrahim et al.
Background: Serum neurofilament light chain (sNfL), a biomarker of axonal damage, has shown promise in clinical studies for monitoring paclitaxel-induced peripheral neurotoxicity (PIPN). The latter involves pathological c...
Population Pharmacokinetics of Voriconazole in Patients Receiving Extracorporeal Membrane Oxygenation [0.03%]
体外膜氧合患者伏立康唑药代动力学的群体分析
Mingyu Meng,Yucheng Yao,Zhuo Huang et al.
Mingyu Meng et al.
Purpose: To characterize the population pharmacokinetics (PPK) of voriconazole (VRC) in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) and to identify factors contributing to pharmacokinetic ...
The Effect of Pharmaceutical Excipients on Protein Chemical Degradation Through Deamidation and Isomerization [0.03%]
药用辅料对蛋白质脱氨和异构化化学降解的影响
Ingrid Ramm,Carl Diehl,Amanda Västberg et al.
Ingrid Ramm et al.
Introduction: Therapeutic proteins are crucial in the treatment of a wide range of diseases. However, the proteins are sensitive to chemical degradation reactions, particularly deamidation and isomerization, which can com...