Transdermal Ionic Liquid Gel of Erlotinib for Localized Breast Cancer Therapy [0.03%]
用于局部乳腺癌治疗的厄洛替尼离子凝胶贴剂
Paulami Datta,Oly Katari,Vivek Yadav et al.
Paulami Datta et al.
Objective: Breast cancer is the second most diagnosed and the fourth leading cause of death among affected women. Here, we have formulated erlotinib (ETB) ionogel to enhance the solubility and transdermal permeation of ET...
A Sulfonamide-Based Compound DRZ-V Enhances Wound Repair via Macrophage-Mediated Responses Associated with TIRAP-NF-κB Signaling [0.03%]
一种磺胺类化合物DRZ-V通过TIRAP-NF-κB信号途径介导的巨噬细胞反应促进伤口修复
Sk Rameej Raja,Alexander G Obukhov,Gajanan N Darwhekar et al.
Sk Rameej Raja et al.
Background: Macrophage polarization is a critical determinant of wound healing outcomes, regulating the transition from inflammation to tissue repair. Failure to shift from a pro-inflammatory M1 phenotype to a reparative ...
A Newly Designed Antibody-drug Conjugate Targeting B7-H3 Demonstrates Enhanced Therapeutic Efficacy Across a Spectrum of Cancers [0.03%]
一种新型针对B7-H3的抗体药物偶联物在一系列肿瘤中显示出增强的治疗效果
Jing Qian,Xinyu Zhu,Xiaobei Zhao et al.
Jing Qian et al.
Introduction: The development of antibody-drug conjugates (ADCs) has accelerated due to their tumor-targeting precision. However, challenges in optimizing the target-linker-payload combination often lead to attrition from...
Vibhuti Agrahari,Dimple Modi,Masumi Dave et al.
Vibhuti Agrahari et al.
Extracellular vesicles (EVs), particularly exosomes, are small membrane-bound vesicles that mediate intercellular communication by transferring bioactive molecules such as proteins, lipids, and nucleic acids. Increasing evidence highlights ...
Dead-Space Microdomains as Explicit Barriers to Extracellular Drug Transport in Alzheimer's Disease [0.03%]
阿尔茨海默病中细胞外药物运输的显性屏障——死腔微区的作用
Dimitrios Charemis,Dimitrios Lampropoulos,Yannis Dimakopoulos et al.
Dimitrios Charemis et al.
Objective: The impact of dead-space (DS) microdomains on cerebral drug penetration has been demonstrated experimentally; yet computational models typically capture their effects indirectly through effective tortuosity par...
Long-Acting Antimalarial Drug Delivery Systems for Chemoprophylaxis: Formulation Strategies and Routes of Administration [0.03%]
长效抗疟药递送系统用于化学预防：配方策略与给药途径
Yogesh Kumar,Vishal Babasaheb Galave,Anil B Jindal
Yogesh Kumar
Background: Malaria chemoprophylaxis generally requires prolonged and frequent administration of antimalarial drugs, which often results in poor patient adherence and reduced prophylactic effectiveness. ...
Correction: Preclinical Evaluation of AAV8-R338L Gene Therapy for Hemophilia: Efficacy, Pharmacokinetics, Distribution, Excretion and Toxicity in Mouse Models and Non-human Primates [0.03%]
AAV8-R338L 血友病基因治疗的临床前评价：在小鼠模型和非人灵长类动物中的疗效、药代动力学、分布、排泄及毒性研究更正通知
Dehu Dou,Jing Lu,Deli Li et al.
Dehu Dou et al.
Published Erratum
Pharmaceutical research. 2026 May 28. DOI:10.1007/s11095-026-04125-0 2026
From Crystal Structure to Dissolution Enhancement: Cocrystal Engineering of Resmetirom to Address Its Solubility Challenge [0.03%]
从晶体结构到溶解度增强：通过共晶工程解决雷斯美蒂若姆溶解性难题
Chen Yang,Rui Zhu,Feipeng Zhang et al.
Chen Yang et al.
Purpose: Resmetirom (RSM), the first FDA-approved drug for non‑cirrhotic steatohepatitis, suffers from poor aqueous solubility, limiting its oral bioavailability. This study aims to enhance the solubility of RSM through ...
High-Dose Sunitinib Accelerates Triple-Negative Breast Cancer Metastasis by Modulating an Immunosuppressive Microenvironment: A Preclinical 4T1 Model Study [0.03%]
高剂量舒尼替尼通过调节免疫抑制微环境加速三阴性乳腺癌转移：4T1模型的临床前研究
Chen Liu,Junsheng Xue,Tianyu Wang et al.
Chen Liu et al.
Background: Sunitinib (SUN), a multi-targeted anti-angiogenic tyrosine kinase inhibitor, could inhibit tumor growth and affect tumor microenvironment (TME). However, survival benefit for triple-negative breast cancer (TNB...
Rational Design, Optimization and Bioinformatic Analysis of Anti-PD-L1 Peptide Conjugated Mocetinostat Prodrug Nanoparticles for Predictive Cancer Chemoimmunotherapeutic Efficacy [0.03%]
基于理性和生物信息学设计的抗PD-L1肽- mocetinostat前药纳米粒用于预测癌症化疗免疫疗效
Sakuntala Gayen,Ishita Sanyal,Souvik Roy
Sakuntala Gayen
Objective: This study aimed to design and optimize anti-PD-L1 peptide-conjugated mocetinostat prodrug nanoparticles (PD-NPs) as a targeted chemoimmunotherapeutic strategy. ...