Bench-to-Bedside Perspectives on Ocular Toxicity of Antibody-Drug Conjugates: Toxicology, Clinical Management and Molecule Optimization [0.03%]
抗体偶联药物的眼毒性： bench to bedside的观点——毒理学、临床管理及分子优化
Jialing Zhang,Weiyu Li,Meng Li et al.
Jialing Zhang et al.
Objectives: The present review aims to provide comprehensive bench-to-bedside insights into ADC-related ocular toxicity for drug designers, pharmaceutical manufacturers, toxicologists, and medical staff, thereby enhancing...
Novel Cocrystal of Quercetagetin: In vitro and in vivo Insights into Biopharmaceutical Performance [0.03%]
檞皮素的新共晶形式：体内外生物药剂学性能研究
Smita Suryawanshi,Parth Shaligram,Rajesh G Gonnade et al.
Smita Suryawanshi et al.
Purpose: Quercetagetin (QTGN) is a naturally occurring flavonol predominantly sourced from marigold flowers and possesses notable therapeutic potential, including antidiabetic, anticancer, antioxidant, anti-inflammatory, ...
From Blood Flow to Tumor Cell Internalization: A Multistage Computational Model of Nanoparticle Dynamics [0.03%]
从血液流动到肿瘤细胞内部化：纳米粒子动态的多阶段计算模型
Álvaro González-Garcinuño,Eva Martin Del Valle,Sasa Kenjeres
Álvaro González-Garcinuño
Background: Understanding the transport of nanoparticles within blood vessels and their distribution in tumor tissues is crucial for the successful implementation of nanotechnological strategies in clinical practice. Alth...
Forecasting the Biological Effect of PEGylated-rHuEPO Candidates in Chronic Kidney Disease Patients using a Middle-out Translation Approach [0.03%]
采用“中轴外推法”预测透析患者PEG化重组人促红细胞生成素候选药物的生物效应
Gledys Reynaldo-Fernandez,Leyanis Rodriguez-Vera,Daniel Amaro et al.
Gledys Reynaldo-Fernandez et al.
Background: Anemia is a common and debilitating complication in patients with chronic kidney disease (CKD), often managed with erythropoiesis-stimulating agents. While PEGylation extends drug half-life, it may alter pharm...
Development of Alcohol-Resistant Extended-Release Formulations: Regulatory Considerations and Formulation Strategies [0.03%]
抗酒精性长效缓释制剂的开发：监管考量与配方策略
Ming Ji,Nitin K Swarnakar,Shanmuka Harish Chalamuri et al.
Ming Ji et al.
Purpose: This study was aimed to develop reservoir-type extended-release (ER) formulations resistant to alcohol-induced dose dumping (ADD) using polyvinyl acetate (PVAc) and polyvinylpyrrolidone (PVP-90). ...
Enabling Anti-inflammatory Activity through Hyaluronan-coated PLGA Nanoparticles Loaded with Carvacrol [0.03%]
通过负载百里酚的透明质酸钠包被PLGA纳米粒发挥抗炎作用
Saniya Salathia,Dimitrios Agas,Maria Rosa Gigliobianco et al.
Saniya Salathia et al.
Objective: Chronic inflammation is characterized by excessive cytokine production and macrophage infiltration, contributing to disease progression. This study aimed to enhance the therapeutic efficacy and local delivery o...
Efficacy of Inhalable Endolysin Cpl-1 Formulations in Combination with Gentamicin or Endolysin Pal in a Murine Lung Infection Model [0.03%]
吸入型内溶菌酶Cpl-1与庆大霉素或Pal内溶菌酶联合用于小鼠肺部感染模型中的疗效研究
Yuncheng Wang,Maxwell T Stevens,Trixie Wang et al.
Yuncheng Wang et al.
Purpose: Inhalable liquid formulation of endolysins represents a promising alternative to conventional antibiotics. Dry powder formulations offer improved stability for endolysin pulmonary delivery. This study aimed to ev...
Ex vivo Tissue Provides Insight into Bleb Dynamics During Large-Volume Subcutaneous Injection [0.03%]
离体组织在大体积皮下注射过程中提供关于泡状物动力学的见解
Taeki Kim,Pierre Artus,Benjamin Berat et al.
Taeki Kim et al.
Purpose: Large-volume subcutaneous injections can create visible protrusions called blebs, whose size and shape affect drug absorption and patient comfort. In vivo pig studies have documented how the bleb dimensions and t...
Aerosol Delivery of Polyelectrolyte Surfactant-Antimicrobial Nanoparticles to the Lungs [0.03%]
肺部递送聚合电解质表面活性剂-纳米抗菌颗粒
Yadiel Varela Soler,Amanda S Padilla-López,Sughosha Rao et al.
Yadiel Varela Soler et al.
Background: Lung infections affect over 80% of adults with cystic fibrosis, with Pseudomonas aeruginosa being a leading pathogen. Although antibiotics are frequently nebulized as standard treatments, the physicochemical e...
Correction: Photosensitizer-Antibody Conjugates (PhotoBodies): Emerging Frontiers in the Field of Theranostics [0.03%]
关于光敏剂-抗体偶联物（PhotoBody）在诊疗一体化领域前沿的更正论文
Sampada Sharad Kulkarni,Prakash Y Khandave,Abhishek K Tiwatane et al.
Sampada Sharad Kulkarni et al.
Published Erratum
Pharmaceutical research. 2026 Jan 8. DOI:10.1007/s11095-025-04009-9 2026