Colloidal Stability of Amorphous Nanoparticles in Solution: Impact of Stabilizer [0.03%]
溶液中无定形纳米颗粒的胶体稳定性：稳定剂的影响
Akshay Narula,Matthew J Nethercott,Paroma Chakravarty et al.
Akshay Narula et al.
Purpose: Amorphous drug nanoparticles can enhance the oral bioavailability of poorly water-soluble drugs, but rapid particle growth limits their effectiveness and manufacturability. Therefore, the goal of this study was t...
Impact of Mixing Approach and Bubble Formation on In Situ Forming Implant Properties [0.03%]
混合计量方法及气泡形成对原位成型植入物性能的影响
Xinhao Lin,Seyyed Majid Eslami,Zixuan Zhen et al.
Xinhao Lin et al.
Purpose: The commercial In situ forming implants (ISFIs) use either a dual-syringe system requiring pre-injection syringe mixing, or a pre-mixed ready-to-inject syringe. The purpose of this study is to comprehensively eva...
Initial Exploration on the Application of the MoCMC Approach for Determining In Vitro Product Comparability [0.03%]
基于MoCMC方法的体外产品可比性判定初步探索研究
Marilyn N Martinez,David G Longstaff
Marilyn N Martinez
Purpose: To provide an initial assessment of the Matrix of Chemistry, Manufacturing and Control (MoCMC) approach for evaluating product physicochemical (Q3) similarity as part of the bioequivalence assessment of products ...
Injectable in-situ Forming Lipid Liquid Crystal for Long-acting Fluocinolone Release in Posterior Ocular Therapy: In-vitro and In-vivo Evaluations [0.03%]
用于玻璃体内长期释放氟轻松的可注射原位形成脂质液晶的体外和体内评价
Malihe Karimi,Mojtaba Abrishami,Mehdi Farzadnia et al.
Malihe Karimi et al.
Objective: Intravitreal injection is a preferred route for targeted drug delivery to the posterior eye. However, commercial non-biodegradable polymeric implants for fluocinolone acetonide (FA) often necessitate surgical r...
Utility of Relative Activity Factors to Determine Fraction Glucuronidation and Clearance of Icenticaftor in Humans [0.03%]
利用相对活性因子确定Icenticaftor在人体中的葡萄糖醛酸结合率和清除率的研究价值
Mitesh Patel,Sahil Shaikh,Felix Huth et al.
Mitesh Patel et al.
Purpose: The purpose of this study is to quantify the contribution of individual UDP-glucuronosyl transferase (UGT) enzymes involved in the glucuronidation of icenticaftor, which is primarily glucuronidated in the human l...
In-vitro Assessment of Immediate Release Rivaroxaban Coated Fixed Dose Combination Tablets with Extended Release Molnupiravir for the Management of Coagulopathy Associated with COVID [0.03%]
体外评估立即释放瑞莫杜抗涂层固定剂量复合片与延长释放莫努匹拉韦治疗COVID相关凝血病的管理效果
Abu Mohiuddin,Sumanta Mondal,Koustav Dutta et al.
Abu Mohiuddin et al.
Purpose: Coagulopathy associated with SARS-CoV-2 infection leads to the formation of abnormal blood clots even in tiny blood vessels, which can lead to severe life-threatening conditions like organ damage, heart attack, a...
Women in Pharmaceutical Sciences: Progress, Possibility, and Lasting Impact [0.03%]
药学科学中的女性：进步、机遇与深远影响
Amy Lavelle
Amy Lavelle
Meta-Analysis and Physiologically-Based Modeling of the Pharmacokinetics and Pharmacodynamics of Dexamethasone in Horses [0.03%]
马用糖皮质激素地塞米松的药代动力学和药效学的荟萃分析及基于生理的建模研究
Ruihong Yu,Pierre-Louis Toutain,Carl Ekstrand et al.
Ruihong Yu et al.
Purpose: Dexamethasone (DEX) is widely used in equine practice for its potent anti-inflammatory effects and diverse studies have examined its pharmacology in horses. We integrated all available pharmacokinetic (PK) and ph...
Innovative Production of Diclofenac Sodium-Loaded Solid Lipid Nanoparticles by Membrane Nanoprecipitation: Evaluation of Encapsulation Efficiency and Photoprotection Ability [0.03%]
膜纳米沉淀法制备固态脂质纳米颗粒载双氯芬酸钠的创新研究：包封率及光保护力评价
Fabio Bazzarelli,Giuseppina Ioele,Martina Chieffallo et al.
Fabio Bazzarelli et al.
Purpose: The stability of diclofenac sodium (DS) in liquid formulation is influenced by environmental factors such as temperature, humidity and light. The encapsulation of this drug in solid lipid nanoparticles (SLNs) can...
Force Distribution and Contact Mechanics in Mini-Tablet Compaction: A Discrete Element Method Study [0.03%]
基于离散单元法的微型片压片过程中的力学分布及接触分析研究
Saeed Najafian,Trong Bien Tran,Bodhisattwa Chaudhuri et al.
Saeed Najafian et al.
Purpose: The purpose of this study was to investigate how powder fill weight, particle size, and particle size distribution influence force transmission and compaction behavior of powders during compaction within narrow d...