Continuous Microfluidic Manufacture of Nano-in-Microparticles Combining 3D-Printed Micromixers and Spray Drying [0.03%]
基于三维打印微混合器和喷雾干燥技术的纳米粒负载微颗粒连续化制备技术
Aytug Kara,Baris Ongoren,Brayan J Anaya et al.
Aytug Kara et al.
Purpose: Conventional nanoparticle manufacturing techniques remain costly, labor-intensive, and difficult to scale, while also being subject to batch-to-batch variability. These limitations hinder their clinical translati...
Assessment of Vancomycin Penetration into Cerebrospinal Fluid in Patients with Ventriculitis Using a Physiologically Based Pharmacokinetic Approach [0.03%]
基于生理学的药代动力学方法评估脑脊液中万古霉素对患者室窦炎的渗透性
Larissa Martins Alves Guimarães,Letícia Oliveira de Vasconcellos Nacif,Jhohann Richard de Lima Benzi et al.
Larissa Martins Alves Guimarães et al.
Introduction: Vancomycin is an antimicrobial agent for treating central nervous system (CNS) infections caused by Gram-positive bacteria. Due to practical and ethical reasons, it is difficult to evaluate vancomycin exposu...
Naringenin Loaded Hydrogel Supports Wound Repair in a Cell Model of Diabetic Skin [0.03%]
载narigenin水凝胶在糖尿病皮肤伤口模型中促进伤口愈合
Mandeep Kaur Marwah,Yukta Sameer Hindalekar,Karan Rana et al.
Mandeep Kaur Marwah et al.
Introduction: Diabetic foot ulcers are a major complication of diabetes, driven by inflammation, oxidative stress, and poor vascular function. Naringenin, a citrus flavonoid, addresses these factors but has low solubility...
Penicillin Concentrations in Oropharyngeal and Frontal Sinus Tissue Following Intravenous Bolus and Continuous Infusion - An Experimental Porcine Study [0.03%]
静脉注射青霉素的浓度：猪身上的实验研究
Pelle Hanberg,Hans Christian Rasmussen,Mats Bue et al.
Pelle Hanberg et al.
Background and purpose: Studies have documented that continuous infusion is superior to bolus infusion in providing longer time with drug concentration above the minimal inhibitory concentration (T > MIC). This porcine st...
Lipid Nanoparticle Development in Practice: Challenges and Collective Insights [0.03%]
脂质纳米颗粒研发实践中的挑战与集体见解
Xiuling Lu,Sheyda Ranjbar,Fan Zhang et al.
Xiuling Lu et al.
Lipid nanoparticles (LNPs) have emerged as a versatile delivery platform for improving pharmacokinetic performance, protecting nucleic acid cargo, and enabling tissue- and cell-specific targeting. Continued advancement of LNP-based therapeu...
Differences in mAb Galactosylation Caused by the Leaching of Manganese Ions from Different Bioreactors [0.03%]
由不同生物反应器中渗漏的锰离子导致的mAb半乳糖化差异
Xiaojing Liu,Guohong Qin,Jiaqi Mao et al.
Xiaojing Liu et al.
Background: Protein N-glycosylation is one of the critical quality attributes of monoclonal antibody (mAb). Evaluating its scalability and batch-to-batch consistency is essential for ensuring process robustness and produc...
Enhanced Solubilization of Ketoprofen Using Triton X-100, Triton X-165, Brij C10, and Their Binary and Ternary Mixed Micelle Systems [0.03%]
表面活性剂胶束体系增强ketoprofen溶解度的研究
Zita Farkaš Agatić,Mladena Lalić-Popović,Nemanja Todorović et al.
Zita Farkaš Agatić et al.
Purpose: This study investigates the thermodynamic behaviour and solubilization efficiency of micellar systems composed of Triton X-100, Triton X-165, and Brij C10, individually and in mixtures, using ketoprofen as a poor...
Potential Enhancement of Topical Drug Delivery Using Grapefruit-derived Nanoparticles Modified Using TAT Peptide [0.03%]
携带TAT肽的纳米粒包裹 topical drug delivery 效果研究
Risa Kanai,Tomohiro Seki,Tomona Yukimura et al.
Risa Kanai et al.
Purpose: Plant-derived nanoparticles (PdNPs) have garnered increasing attention as versatile tools for nucleic acid delivery, and they have been investigated for the transdermal delivery of encapsulated nucleic acids. How...
In Silico Analysis of Potential Vaccine Antigens for the Treatment of Crimean-Congo Hemorrhagic Fever Virus (Cchfv) [0.03%]
体外分析克里米亚刚果出血热病毒(CCHFV)潜在疫苗抗原的有效性
Deniz Tülümen,Esra Aydemir,Furkan Ayaz
Deniz Tülümen
Background: Crimean-Congo hemorrhagic fever virus (CCHFV), identified by the World Health Organization(WHO) as a potential epidemic threat, is a tick-borne Nairovirus primarily transmitted by Hyalomma marginatum species. ...