Machine Learning Prediction of Protein Adsorption on Drug-delivering Nanoparticles: A Literature Survey and Need for Future Development [0.03%]
基于文献调研的药物递送纳米颗粒蛋白质吸附之机器学习预测及未来展望
Koushiki Basu,Venkata S Chelagamsetty,Veronica A Ruiz-Avila et al.
Koushiki Basu et al.
Nanoparticles (NPs), due to their small size and large surface area, have advanced their use as drug carriers for delivering various therapeutic molecules. When entering biological environments, nanoparticles typically adsorb proteins, form...
Comparative Formulation and Physicochemical Evaluation of Orodispersible Films Fabricated via Pneumatic and Syringe-Based 3D Printing [0.03%]
基于气动和注射器的3D打印制备口腔速溶膜的比较研究及理化评价
Ishwor Poudel,Nur Mita,James Scherer et al.
Ishwor Poudel et al.
Objective: Orodispersible films (ODF) blend the dose accuracy of solid dosage forms and the ease of administration of liquid dosage forms, hence offer many advantages. This study investigated the feasibility of two extrus...
Preparation and Characterization of Novel Pan-RAS Inhibitor Loaded Ultraflexible Liposomes for the Topical Prevention or Treatment of Skin Melanoma [0.03%]
一种新型泛RAS抑制剂载药超柔脂质体的制备及其用于皮肤黑色素瘤局部防治的研究
Shivani A Dave,Adam B Keeton,Gary A Piazza et al.
Shivani A Dave et al.
Purpose: There are no preventive and few therapeutic options for melanoma, an aggressive skin cancer, especially in situations where N-Ras mutations are present. The new pan-Ras inhibitor ADT-007 has promise for treating ...
Amyloid Light Chain Proteins in Cardiovascular Disease: Pathogenesis and Emerging Therapies for Cardiac Amyloidosis [0.03%]
轻链淀粉样蛋白在心血管疾病中的致病机制及心脏淀粉样变性的新兴疗法
Hanyan Hu,Yiqiang Wang,Mingming Xu
Hanyan Hu
Cardiac amyloidosis caused by amyloid light chain proteins is a life-threatening manifestation of systemic amyloid light chain amyloidosis, yet it remains underrecognized. This review explores the pathogenic mechanisms underlying cardiac in...
Emerging Technologies and Integrated Interdisciplinary Strategies for Mitigating Protein Aggregation in Therapeutic Formulations [0.03%]
用于治疗配方中蛋白质聚集的新兴技术及学科综合策略
Haomin Wu,QinXi Fan,Zheng Zhang et al.
Haomin Wu et al.
Background: Therapeutic proteins are playing an increasingly important role in marketed drugs and clinical candidates. However, their development still faces major challenges, particularly aggregation. ...
Modulation of Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Gastrointestinal Cancers by Phytochemicals [0.03%]
植物化学物质调节胃肠癌中丝裂原活化蛋白激酶(MAPK)信号通路的作用机制研究进展
Pratibha Pandey,Meenakshi Verma,Samra Siddiqui et al.
Pratibha Pandey et al.
The purpose of this review is to provide a concise overview of phytochemicals and their possible effects on gastrointestinal (GI) malignancies via modification of the mitogen-activated protein kinase (MAPK) signaling cascade. Abnormal activ...
Fabrication and Evaluation of Thermoresponsive GPNMB-Hydrogels as an Innovative Osteogenic Therapeutic Strategy [0.03%]
一种创新的骨形成治疗策略：具有温度响应性的GPNMB-水凝胶的制备及评价
Tori Czech,Evin Hessel,Jenna Knowles et al.
Tori Czech et al.
Purpose: Earlier studies have reported the ability of GPNMB protein (GPNMB) to promote osteoblast differentiation and function. However, the realization of clinical potential of GPNMB in bone regeneration will require sui...
Effect of Molecular Size on Ocular Drug Distribution After Intravitreal Injection Using Computed Tomography and Mathematical Spatial Modeling [0.03%]
计算 tomography 和数学空间模型对玻璃体腔注射后分子大小对眼部药物分布的影响研究
Kentaro Konishi,Sadaaki Kimura,Tsuyoshi Minematsu et al.
Kentaro Konishi et al.
Purpose: Intravitreal injection is an administration route for ocular therapeutics of different molecular sizes, including antibodies, antisense oligonucleotides, and adeno-associated viruses. The purpose of this study wa...
Active Targeting of Colorectal Cancer Using Chemotherapy-Loaded Nanoparticles Functionalized with a Folate Receptor-α (FRα) Ligand, Pemetrexed [0.03%]
使用加载了培美曲塞的叶酸受体α（FRα）配体功能化纳米颗粒进行靶向结直肠癌化疗
Mohammad Alnatour,Ramkrishna Sen,Leela Sai Lokesh Janardhanam et al.
Mohammad Alnatour et al.
Purpose: Colorectal cancer (CRC) is a leading cause of cancer mortality with current chemotherapeutic strategies often limited by systemic side effects and suboptimal tumor targeting. This study aimed to enhance the deliv...
A Tale of Two Stressors in Biologic Drug Product Development: Shaking Mode and Primary Packaging [0.03%]
生物制剂开发中的两种应激因素：摇摆模式和主要包装容器的影响故事
Siddhanth Hejmady,Elham Taherian,Reza Nejadnik
Siddhanth Hejmady
Purpose: Mechanical, interfacial, and shear stresses encountered during development, manufacturing and transportation of biologics can compromise monoclonal antibody (mAb) stability. However, most scale-down shaking model...