Raman Spectroscopy for Characterizing Monoclonal Antibody Reduction: A Process Analytical Technology Approach for Antibody-Drug Conjugation Process Development [0.03%]
拉曼光谱在单克隆抗体还原表征中的应用：一种抗体药物偶联物工艺开发的PAT策略
David Pople,Zhenshu Wang,Anton Kozyryev et al.
David Pople et al.
Background: Controlled disulfide bond reduction is critical in antibody-drug conjugate (ADC) manufacturing, enabling site-specific conjugation and desired drug-to-antibody ratios. Current characterization relies on time-c...
Danforth P Miller,Nani P Kadrichu,Thomas E Tarara et al.
Danforth P Miller et al.
Purpose: To develop an inhaled formulation of relaxin-H2 that achieves sustained concentrations of protein above 10 ng/mL in serum and epithelial lining fluid over 24 h, thereby enabling chronic administration of the medi...
Variance-Consistent Covariate Modeling from Posterior Summaries in Population Pharmacokinetics [0.03%]
基于群体药代动力学后验概要的一致协变量模型方差建模方法
Junya Ooka,Mizuki Uno,Yuta Nakamaru et al.
Junya Ooka et al.
Purpose: Systematic covariate modeling in nonlinear mixed-effects (NLME) analysis is computationally intensive due to repeated refitting to concentration-time data. Although empirical Bayes estimates (EBEs) facilitate scr...
Enabling Personalized Dose Formulation by Evaporative Crystallization Process [0.03%]
通过蒸发结晶工艺实现个性化剂型配方
Nicole M Torres-Colón,Lesly Carmona-Sarabia,Aliou Mbodji et al.
Nicole M Torres-Colón et al.
Purpose: Evaluating a solution-based drug impregnation strategy for individualized dose formulation of warfarin sodium isopropanol (WS-IPA), a drug with a narrow therapeutic index, using microcrystalline cellulose (MCC) p...
Osmolyte-Based Formulations for Enhanced Thermal Stability of mRNA Drug Substance: A Systematic Screening and Optimization Study [0.03%]
基于渗透压物质的mRNA药物活性成分增强热稳定性的体系筛选与优化研究
Anandi Chowdhury,A Rita Silva-Santos,Ana M Azevedo et al.
Anandi Chowdhury et al.
Purpose: Stability of messenger RNA (mRNA) is a critical factor in the development and storage of mRNA-based vaccines. In this study, we systematically examine the effects of addition of various osmolytes (and their combi...
Design, Synthesis and Characterization of Anti-CTLA4 Peptide Conjugated Gemcitabine Prodrug Nanoparticles for Targeted Lung Cancer Chemoimmunotherapy [0.03%]
设计、合成和表征抗CTLA4肽结合的吉西他滨前药纳米颗粒用于靶向肺癌化疗免疫治疗
Soumyadeep Chattopadhyay,Sakuntala Gayen,Souvik Roy
Soumyadeep Chattopadhyay
Objective: Lung cancer continues to be a major contributor to global cancer mortality due to extensive tumor heterogeneity, drug resistance, and limited efficacy of conventional therapies. To address these limitations, th...
Leveraging Carnitine-functionalized Lipid Nanocarrier based Targeted Delivery of A1874 PROTAC for Glioblastoma [0.03%]
利用肉毒碱功能化脂质纳米递送系统针对胶质母细胞瘤进行PROTAC(A1874)靶向给药
Himaxi Patel,Xiang Chen,Afsin Malik et al.
Himaxi Patel et al.
Purpose: Glioblastoma(GBM) is highly aggressive and therapeutically refractory brain malignancy. Despite maximal intervention, patient prognosis remains dismal. A major obstacle in its management is the limited permeation...
Impact of Febrile State on Vancomycin Clearance in Pediatric Patients: Insights From Population Pharmacokinetic Modeling [0.03%]
发热状态对儿科患者万古霉素清除的影响：基于人群药代动力学模型的见解
Ryota Tanaka,Ayato Sawaguchi,Tomoyuki Mizuno et al.
Ryota Tanaka et al.
Objective: Augmented renal clearance is increasingly recognized in pediatric patients with febrile neutropenia (FN), leading to enhanced elimination of renally cleared antimicrobials including vancomycin (VCM). Although f...
Sustained Intra-Articular Delivery of Triple Therapeutics Using a Phase-Transition Phospholipid-Based Gel for Effective Treatment of Gouty Arthritis [0.03%]
用于有效治疗痛风性关节炎的基于磷脂的相变凝胶的长效关节内递送三重疗法
Sirui Ma,Jing Yang,Ao Li et al.
Sirui Ma et al.
Purpose: This study developed a coordinated-delivery phospholipid-based gel for therapeutics with distinct physicochemical properties to overcome the limitations of current monotherapies for gouty arthritis (GA), achievin...
Spray Dried Lysozyme Microspheres: Morphological Evolution and Enzymatic Activity Retention [0.03%]
喷干溶菌酶微球：形态演化及 enzymatic activity retention
Mengyuan Li,Shen Yan,Shengyu Zhang et al.
Mengyuan Li et al.
Purpose: Conventional spray drying often produces heterogeneous enzyme powders because of broad droplet size distributions and complex turbulent flow fields, limiting mechanistic understanding of particle formation and qu...