Particle-Size-Determined Crystallization and Dissolution Behavior of Amorphous Griseofulvin [0.03%]
无定形灰黄霉素的结晶和溶解行为取决于粒径大小
Daniela Košťálová,Roman Svoboda,Kateřina Kozlová et al.
Daniela Košťálová et al.
Purpose: Amorphous active pharmaceutical ingredients (APIs) are generally considered to have significantly higher bioavailability, compared to their crystalline counterpart, due to the enhanced solubility of the disordere...
Expression and Functional Evaluation of ABC and SLC Transporters in Human Choroid Plexus Papilloma (HIBCPP) Cells: A Human Blood-Cerebrospinal Fluid Barrier Model [0.03%]
人脑脊液屏障模型中的ABC和SLC转运蛋白在人室管膜细胞系(HIBCPP)中的表达及功能评价
Toshiki Kurosawa,Sumio Ohtsuki,Hiroshi Ishikawa et al.
Toshiki Kurosawa et al.
Purpose: Human choroid plexus papilloma (HIBCPP) cells derived from choroid plexus papilloma in the lateral ventricle are considered suitable model cells for the blood-cerebrospinal fluid barrier (BCSFB). Therefore, in th...
Investigation of Phytol as an Inhibitor of the Efflux Pump (QacA/B) in Staphylococcus aureus: in silico and in vitro Studies [0.03%]
植物精油主要成分香芹酚抑制金黄色葡萄球菌解偶联蛋白(QacA/B)的体内和体外研究
José Weverton Almeida-Bezerra,Carlos Alonso Leite Dos Santos,Saulo Almeida Menezes et al.
José Weverton Almeida-Bezerra et al.
Objective: Staphylococcus aureus is a microorganism that can behave as a commensal or as a life-threatening pathogen. Its remarkable capacity to acquire resistance to antimicrobial agents, particularly through mechanisms ...
From Clinical Trials to Commercialization: Perspectives in Human Vaccine [0.03%]
从临床试验到商业化：人用疫苗的视角分析
Nidhi Mehrotra,Padmavati Manchikanti
Nidhi Mehrotra
Although India ranks among the largest producers and exporters of human vaccines, the delay in launch of newer therapeutics is larger than the average in G20 nations. This study aims to assess the stakeholders' perspective on the coherence,...
Trimorphism in riluzole salicylate: screening, crystal structures and solution thermodynamics [0.03%]
雷洛昔芬水杨酸的三态现象：筛选、晶体结构及溶液热力学
Alexander P Voronin,Anna G Ramazanova,Anna V Vologzhanina et al.
Alexander P Voronin et al.
Purpose: This study investigated the phenomenon of polymorphism in the pharmaceutical salt riluzole salicylate with the aim to modify the aqueous solubility and dissolution rate of riluzole. ...
Transdermal Drug Delivery Systems: A Comprehensive Review of Mechanisms, Technologies, and Clinical Applications [0.03%]
经皮给药系统：机制、技术及临床应用综述
Fengxia Xu,Zhuoya Qiu,Mengru Zhang et al.
Fengxia Xu et al.
Background: Transdermal Drug Delivery Systems (TDDS) offer a non-invasive route for sustained systemic or localized drug delivery. By bypassing hepatic first-pass metabolism and improving bioavailability, TDDS enhances pa...
QbD Optimized Nanoemulsion Based Topical Formulation of Jatyadi Taila: Unveiling its In Vitro and In Vivo Efficacy for Enhanced Wound Healing [0.03%]
基于QbD优化的纳米乳液外用制剂促进 Jayadi Taila 疑似伤口愈合的 in vitro 和 in vivo 效力研究
Shivam Vijay Chavan,Sonia Guha,Kaisar Raza et al.
Shivam Vijay Chavan et al.
Background: Jatyadi Taila (JT) is an Ayurvedic herbal formulation traditionally used for wound healing. However, its oily nature restricts clinical use due to greasy texture, slower absorption, occlusiveness, and applicat...
Photosensitizer-Antibody Conjugates (PhotoBodies): Emerging Frontiers in the Field of Theranostics [0.03%]
光敏剂-抗体偶联物(光体)：治疗诊断学领域的前沿领域
Sampada Sharad Kulkarni,Prakash Y Khandave,Abhishek K Tiwatane et al.
Sampada Sharad Kulkarni et al.
Background: The beginning of precision medicine has come to rise in a new era of targeted therapies. Among these innovations, light-activatable antibody photo drug conjugates/photoimmunoconjugates termed as "PhotoBodies" ...
Biotechnology in Brazil: Current State, Gaps, and Strategic Recommendations [0.03%]
巴西的生物技术：现状、差距及战略建议
Frederico Severino Martins,Gabriel Bottos,Amanda Silva Hecktheuer et al.
Frederico Severino Martins et al.
Biotechnology is becoming a key driver of innovation in health, agriculture, industry, and sustainability worldwide. Brazil has made significant progress in this field, thanks to its strong research institutions, diverse ecosystems, and act...
Emerging Role of Nanostructured Lipid Carriers in Overcoming Cancer Treatment Challenges [0.03%]
纳米结构脂质载体在克服癌症治疗挑战中的新兴作用
Revati T Deore
Revati T Deore
Cancer continues to remain a global health challenge, and conventional chemotherapy has its own limitations such as poor solubility, systemic toxicity, nonspecific biodistribution, and multidrug resistance (MDR). Nanostructured Lipid Carrie...