Multi-Target Anticoagulant Regulation by Peptides from Medicinal Leeches: A Unique Natural Strategy against Thrombosis [0.03%]
药用蚯蚓肽的多靶标抗凝调节作用：一种独特的抗血栓形成策略
Feng Shi,Qingmei Hu,Yiquan Lin et al.
Feng Shi et al.
Background: Thrombotic diseases remain a major global health burden. Current anticoagulants are often limited by bleeding risks and narrow therapeutic windows, largely due to their single-target mechanisms. In contrast, m...
A Novel Non-Aqueous Emulsification Platform to Fabricate Polymeric Microspheres for Sustained Delivery of Biologics [0.03%]
一种新型非水相乳化平台技术，用于生物制剂缓释聚合物微球的规模化制备研究
Nishant S Kulkarni,Roshan James,Aishwarya Saraswat et al.
Nishant S Kulkarni et al.
Objective: Polymeric microspheres (MS) have been developed with moderate success using aqueous emulsification (AqE) for small molecules and peptides with a few approved products. AqE faces a challenge to achieve optimal e...
Intracerebral Distribution of Drugs with Diverse Blood-brain Barrier Transport Characteristics: In vivo Analysis using Brain Microdialysis in Cynomolgus Monkeys [0.03%]
具有不同血脑屏障转运特性的药物在大脑内的分布：采用食蟹猴脑微透析进行的体内分析研究
Takuya Fujita,Yukari Kamikozawa,Makoto Ozawa et al.
Takuya Fujita et al.
Objective: The purpose of this study is to analyze the impact of the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) transport characteristics of drugs on their intracerebral distribution in male c...
Deep Dive into Generic Drug Applications to Seek Harmonization of Bioequivalence Criteria for Narrow Therapeutic Index Drugs [0.03%]
以窄治疗指数药物 bioequivalence 标准的国际协调为目标而深入探讨仿制药的申报资料
Mirette Mina,Zhen Zhang,Wanjie Sun et al.
Mirette Mina et al.
Purpose: U.S. Food and Drug Administration (FDA) recommends reference scaled limits and variability comparison for bioequivalence (BE) demonstration of narrow therapeutic (NTI) drugs while most other regulatory agencies a...
Physicochemical Differences Observed in Photostability Studies of Lyophilized, Reconstituted, and Diluted Somatropin [0.03%]
冷冻干燥生长激素的光稳定性研究中的物理化学差异
Jordan D Pritts,Uriel Ortega-Rodriguez,V Ashutosh Rao
Jordan D Pritts
Background: While photostability testing conditions for biologics are often based on small molecule standards, the unique characteristics of proteins necessitate a deeper understanding of appropriate testing and controls....
Development, Optimization, and Evaluation of Nano Self-Emulsifying Drug Delivery System Formulation Platform for Oral Bioavailability Enhancement of Sulfasalazine and Disulfiram in Lung Cancer Chemoprevention [0.03%]
口服自给纳米 self-emulsifying drug delivery system 的开发，优化及评估：用于肺癌化学预防中的柳氮磺胺吡啶和双硫仑生物利用度增强
Preshita Desai,Katherine Bang,Mohammed Riaz Hasan Chowdhury et al.
Preshita Desai et al.
Objective: Lung cancer chemoprevention modalities are gaining wide attention as it is the second most diagnosed cancer type and the leading cause of cancer-related deaths. Our previous studies reported unique lung cancer ...
M N V Ravi Kumar
M N V Ravi Kumar
How Breathing Interruptions Influence pMDI Aerosol Delivery: A CFD Study in a Realistic Airway [0.03%]
呼吸中断对pMDI气溶胶递送影响的计算流体动力学研究： realistic airway中的研究
Mahsa Jahed,Janusz Kozinski,Leila Pakzad
Mahsa Jahed
Objective: The effectiveness of pressurized metered-dose inhalers (pMDIs) relies on correct inhalation technique. While prior studies investigated idealized breathing, the impact of real-life irregularities remains less u...
Rational Design of a Bioconjugated Antitumor Peptide with Tumor-Selective Targeting and Microenvironment-Responsive Activation [0.03%]
一种具有肿瘤选择性靶向和微环境响应激活的抗肿瘤肽的理性设计
Chunlai Feng,Wen Deng,Min Cai et al.
Chunlai Feng et al.
Objective: Bioactive peptides derived from natural or synthetic sources have shown significant potential for cancer therapy; however, their clinical application is often limited by poor tumor selectivity and systemic toxi...
Development and optimisation of Polyelectrolyte Complex Nanoparticles Loaded with Sorafenib by Central Composite Design (CCD): In Vitro and In Vivo Studies for the Treatment of Triple Negative Breast Cancer [0.03%]
采用中心组合设计（CCD）开发和优化载有索拉非尼的聚电解质复合纳米颗粒：体外和体内研究用于治疗三阴性乳腺癌
Sangita A Kale,Savita S Deokar,Karimunnisa S Shaikh
Sangita A Kale
Introduction: Sorafenib (SOR) is a low-dose multikinase inhibitor that suppresses angiogenesis by blocking vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptors. The aim of the pres...