Lapatinib-Loaded Glucose-Functionalized Silver Nanoparticles Enhance Efficacy in HER2-Positive Breast Cancer Cells and Modulate Survival-Associated Genes [0.03%]
葡萄糖功能化的阿霉素/拉帕替尼载药银纳米颗粒的合成及其对HER2阳性乳腺癌细胞的影响
Behnaz Dolatabadi,Maryam Peymani,Mehrdad Hashemi et al.
Behnaz Dolatabadi et al.
Background: Lapatinib is a dual EGFR/HER2 tyrosine kinase inhibitor used in HER2-positive breast cancer (BC). Here, we identified prognostic genes modulated by lapatinib and evaluated whether glucose-functionalized, lapat...
Estimating Human Jejunal Effective Permeability Using Numerical Deconvolution of Oral Solution Concentration Data [0.03%]
用人肠血药浓度时间曲线数值反卷积计算小肠有效透膜系数
Wenqian Zhang,Jia Geng,Xingrui He et al.
Wenqian Zhang et al.
Aims: Accurate determination of human intestinal effective permeability (Peff) typically relies on technically challenging human intestinal perfusion experiments. This study aimed to develop a numerical deconvolution meth...
Quantitative Analysis of the Effect of Gastrointestinal Water Dynamics on Oral Drug Absorption using a Physiologically Based Integrated Liquid and Intestinal Absorption Drug (ILIAD) Pharmacokinetic Model [0.03%]
基于生理的集成液体和肠吸收药物动力学模型下的胃肠道水分动态变化对口服药物吸收影响的定量分析
Satoru Suzuki,Ikumi Tamai,Yoshiyuki Shirasaka
Satoru Suzuki
Purpose: This study aims to develop a physiologically based pharmacokinetic (PBPK) absorption model incorporating gastrointestinal (GI) fluid dynamics and to quantitatively evaluate the effects of GI fluid dynamics on the...
The Advanced Integrated Respiratory (AIR) Model: Integration of Air-Liquid Interface Cell Cultures within a Human Airway Model for Inhalation Toxicology [0.03%]
先进的综合呼吸模型(AIR模型): 将气液界面细胞培养与人体呼吸道模型相结合应用于吸入毒理学研究
Patrick He,Hanieh Gholizadeh,Damien Chong et al.
Patrick He et al.
Purpose: The Advanced Integrated Respiratory (AIR) model was developed as a physiologically relevant benchtop system designed to assess aerosol deposition and interactions within the respiratory tract. ...
Role of ITIH4 in Modulating YAP/TAZ-Mediated Apoptosis of Type II Alveolar Epithelium during Acute Respiratory Distress Syndrome [0.03%]
ITIH4在急性呼吸窘迫综合征期间调节II型肺泡上皮细胞YAP / TAZ介导的凋亡中的作用
Yu-Syuan Shih,Xiao-Yue Chen,Yi-Wei Lin et al.
Yu-Syuan Shih et al.
Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is a type II acute-phase protein with anti-inflammatory and anti-apoptotic properties. This study investigated the role of ITIH4 in regulating Hippo signaling and alveolar epithelial type ...
Noelia Pérez-Gómez,María Ángeles Martínez-Zamora,Francisco Carmona et al.
Noelia Pérez-Gómez et al.
Background: Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity. It affects approximately 10-15% of women of reproductive age globally and is...
Silencing CD24 Inhibits Proliferation, Migration, and Chemoresistance in Triple-Negative Breast Cancer Cells [0.03%]
沉默CD24基因可抑制三阴性乳腺癌细胞的增殖、迁移和耐药性
Yanli Liu,Yuhan Guo,Chien-Yu Lin et al.
Yanli Liu et al.
Purpose: The expression of CD24 is significantly higher in triple-negative breast cancer (TNBC) compared to estrogen receptor and progesterone receptor-positive (ER+ PR+) breast cancer and normal breast tissue. CD24 overe...
Cholesterol-Based Lipid Nanoparticles as an Intracellular Drug Reservoir for Enhanced Tumor Therapy [0.03%]
基于胆固醇的脂质纳米颗粒作为细胞内药物仓库的增强肿瘤治疗研究
Qi Jiang,Yihe Qiu,Peirong Li et al.
Qi Jiang et al.
Objective: Cancer remains a critical public health challenge. Conventional anti-tumor drugs are often limited by their short half-life and the requirement for frequent and/or high-dose administration, highlighting the urg...
Targeted Gene Therapy for Mutated H-ras and C-raf.1 Genes Exhibited Variable Efficacy in Inhibiting Hepatocellular Carcinoma in Rats: A Mechanistic Approach [0.03%]
靶向基因治疗对携带突变H-ras和C-raf.1基因的肝细胞癌抑制效果不同：机制方法研究
Alankar Mukherjee,Samrat Chakraborty,Ramkrishna Sen et al.
Alankar Mukherjee et al.
Objective: Mutated H-ras or c-raf.1 gene expressions are often associated with HCC development and progression. Using intravenous administration of respective backbone modified antisense oligomer (ASO) in chemically induc...
Application of a Stochastic Simulation-estimation Approach to Optimize Pharmacokinetic Study Design in the Context of Paediatric Extrapolation: A Tool to Support Decision-making by Drug Sponsors and Regulators [0.03%]
一种随机模拟估算方法在儿科外推药代动力学研究设计中的应用：支持申办方和监管机构决策的工具
Happy Phanio Djokoto,Lara Ernst,Jean-Michel Dogné et al.
Happy Phanio Djokoto et al.
Background: Extrapolation-based approaches are widely used in paediatric drug development. These often rely on pharmacokinetic (PK) matching to support inference on the benefit-risk balance (BRB). PK-based extrapolation r...