Fresh 3D Printing of Spanlastics Hydrogel for Drug Delivery Applications In Vitro [0.03%]
用于药物输送的Spanlastics水凝胶的新型三维打印技术（体外）
Elom Doe,Abigail Alabi,Leela Raghava Jaidev Chakka et al.
Elom Doe et al.
Purpose: To develop a localized delivery implant by integrating doxorubicin loaded spanlastic vesicles within Freeform Reversible Embedding of Suspended Hydrogels (FRESH) printed alginate constructs. ...
Integrated Experimental and Molecular Modeling Techniques to Investigate the Buffer Effects on Glucagon Stability [0.03%]
整合实验与分子模拟研究缓冲体系对胰高血糖素稳定性的影响
Zi-Ting Xu,Bogang Li,Jiayin Deng et al.
Zi-Ting Xu et al.
Purposes: Peptide drugs are a vital category of biologics. However, unlike the well-studied effects of buffers on small-molecule or macromolecule drugs, the understanding of selecting appropriate buffers for peptide formu...
Impurity Characterization Across Drug Development Stages: Analytical Methodologies and Regulatory Perspectives [0.03%]
药品研发各阶段杂质特征分析方法及监管考量
Subathra Ramamoorthy
Subathra Ramamoorthy
The rigorous identification, quantification, and control of impurities are fundamental to ensuring the safety, efficacy, and quality of pharmaceutical products throughout the drug development lifecycle. As unavoidable byproducts of complex ...
Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C Disease [0.03%]
用于提高Rab7-GTP酶活性和降低Niemann-Pick C疾病胆固醇积累的小分子
Mai K L Nguyen,Maya R Nikenich,Kim Seifert et al.
Mai K L Nguyen et al.
Purpose: Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative chol...
Solid-State Stability of Pentobarbital in Fast-Dissolving Suppositories: Implications for Dissolution Behavior and Pediatric Formulation Performance [0.03%]
戊巴比妥在快速溶解栓剂中的固态稳定性：对溶解行为和儿科制剂性能的影响
Aurélien Freisz,Imen Dhifallah,Philip Chennell et al.
Aurélien Freisz et al.
Background: Safe and well-tolerated sedative formulations are essential in pediatric procedural care. Pentobarbital, a short-acting barbiturate, remains widely used for pediatric sedation. However, its oral administration...
Near UV and Visible Light-Induced Degradation of IgG2: Photo-Fenton Reaction in Citrate Buffer [0.03%]
近紫外和可见光诱导的IGG2降解：柠檬酸盐缓冲液中的光芬顿反应
Natalia Subelzu,Olivier Mozziconacci,Christian Schöneich
Natalia Subelzu
Purpose: Evaluation of the stability of an IgG2 in citrate buffer, upon exposure to near-UV and visible light and in the presence of relevant trace amounts of iron. ...
Spatial Targeting of Sialic Acid Receptors for MRI/BNCT-Integrated Boron Drug-Based Antitumor Therapy [0.03%]
基于MRI/BNCT集成硼药物的抗肿瘤治疗中岩藻糖受体的空间靶向作用
Xiaoyan Sun,Yaxin Qin,Zhiqing Ben et al.
Xiaoyan Sun et al.
Objective: Boron neutron capture therapy (BNCT) is limited by inadequate boron delivery to tumor cells and the inability to visualize boron agents for personalized treatment. This study introduces DOTA-BPA-Gd, a dual-func...
A Top-Down Physiologically Based Pharmacokinetic Modeling Approach to Explore Unexpected Bio-inequivalence of Experimental Oral Formulations in Dogs [0.03%]
一种基于生理的 topsy-turvy 药物动力学模型方法探究犬实验口服制剂意外生物不等效性问题
Marilyn N Martinez,Viera Lukacova,Shasha Gao et al.
Marilyn N Martinez et al.
Purpose: A physiologically based pharmacokinetic (PBPK) modeling approach was used to explore potential reasons for the unexpected in vivo/in vitro inconsistencies previously observed in an investigation exploring the com...
Development of Proniosomal Dry Powder for Dual Pulmonary Delivery of Salbutamol Sulfate and Carvacrol: A Design of Experiment Approach [0.03%]
一种用于开发用于沙丁胺醇硫酸盐和百里酚的肺部双重给药的前包载干粉的设计实验方法
Deepa Neopane,Poonam Kushwaha,Badruddeen
Deepa Neopane
Background: Proniosomes are dry, free-flowing, carrier-based systems designed to enhance pulmonary drug delivery and improve the aerosolization of therapeutic agents. Such systems are gaining attention for optimizing the ...
Physicochemical and Biological Characterization of the TLR7 Agonist SZU-106 [0.03%]
TLR7激动剂SZU-106的理化及生物活性特征研究
Martin Herbst,Johannes Kipp,Sonja M Kessler et al.
Martin Herbst et al.
Objective: Toll-like receptor 7 (TLR7) recognizes single-stranded RNA and plays a crucial role in initiating immune responses against viral pathogens. This study characterizes SZU-106, a recently developed Toll-like recep...