Advances and Further Comparison of Software Tools for Fisher Information Matrix-Based Design Evaluation in Pharmacometrics [0.03%]
基于Fisher信息矩阵的药代动力学设计评估软件工具的发展及其进一步比较研究
Lucie Fayette,Karl Brendel,France Mentré
Lucie Fayette
Aim: Before conducting a clinical study involving pharmacometrics analyses using Non-Linear Mixed Effects Models (NLMEM), study design can be evaluated by computing the Fisher Information Matrix (FIM) via first-order mode...
Evaluation of sNfL as a Biomarker for Paclitaxel-Induced Peripheral Neurotoxicity Through an Integrated PKPD Model [0.03%]
通过整合PKPD模型评估sNfL作为紫杉醇诱导的外周神经毒性的生物标志物的价值
Eman I K Ibrahim,Milda Girdenyté,Yang Hu et al.
Eman I K Ibrahim et al.
Background: Serum neurofilament light chain (sNfL), a biomarker of axonal damage, has shown promise in clinical studies for monitoring paclitaxel-induced peripheral neurotoxicity (PIPN). The latter involves pathological c...
Population Pharmacokinetics of Voriconazole in Patients Receiving Extracorporeal Membrane Oxygenation [0.03%]
体外膜氧合患者伏立康唑药代动力学的群体分析
Mingyu Meng,Yucheng Yao,Zhuo Huang et al.
Mingyu Meng et al.
Purpose: To characterize the population pharmacokinetics (PPK) of voriconazole (VRC) in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) and to identify factors contributing to pharmacokinetic ...
The Effect of Pharmaceutical Excipients on Protein Chemical Degradation Through Deamidation and Isomerization [0.03%]
药用辅料对蛋白质脱氨和异构化化学降解的影响
Ingrid Ramm,Carl Diehl,Amanda Västberg et al.
Ingrid Ramm et al.
Introduction: Therapeutic proteins are crucial in the treatment of a wide range of diseases. However, the proteins are sensitive to chemical degradation reactions, particularly deamidation and isomerization, which can com...
Investigating the Potential of High Permeation Vesicle-Based Methotrexate Gel for Localized Therapy in Rheumatoid Arthritis [0.03%]
用于局部治疗类风湿性关节炎的高渗透囊泡基甲氨蝶呤凝胶的潜力研究
Keshav Kumar,Junia Akhtar,Sayali Dighe et al.
Keshav Kumar et al.
Objective: Methotrexate (MTX) is a clinically approved, potent disease-modifying antirheumatic drug used to manage rheumatoid arthritis. However, its systemic administration is associated with severe toxicity and bioavail...
VEGF and Neurotrophins Interaction in the Retinal Neurovascular Unit Homeostasis: A Target for Ocular Disease Treatment and Management [0.03%]
视网膜神经血管单元稳态中VEGF与神经营养素的相互作用：眼部疾病治疗和管理的新靶标
Annamaria Di Criscio,Pamela Rosso,Elena Fico et al.
Annamaria Di Criscio et al.
Emerging evidence underscores the central role of the retinal neurovascular unit (RNVU) in the pathogenesis of major retinal disorders, including diabetic retinopathy, age-related macular degeneration, and glaucoma. Traditionally considered...
Prediction of Large-Scale Adsorption Process Parameters Using Two-Mechanism Langmuir Constants [0.03%]
基于双机制Langmuir吸附常数预测大规模吸附工艺参数
Zaid Assaf,Dale Eric Wurster
Zaid Assaf
Fitting the Langmuir-Like Equation to adsorption isotherms provides capacity and affinity constants which allow fundamental understanding of adsorption but are not helpful for large-scale processes where the relation to the initial concentr...
Continuous Electrospraying of Inhalable Biological Drug Products: Novel Formulation and Manufacturing Technology [0.03%]
可吸入型生物药物产品的连续电喷雾制备技术及新型配方研究
Saeed Najafian,Yu Lei,Da Hye Yang et al.
Saeed Najafian et al.
Purpose: Traditional pharmaceutical manufacturing largely depends on batch processes that contribute to equipment downtime, higher carbon footprint, contamination risks, and elevated operational costs. Additionally, the o...
Development and Validation of an Efficient In vitro Bioassay for Potency Estimation of Recombinant Human Erythropoietin Formulations [0.03%]
一种用于重组人促红细胞生成素药物效力估算的高效体外生物检定法的开发和验证
Nupur Garg,Priyanka Gupta,Charu Mehra Kamal
Nupur Garg
Purpose: Recombinant human erythropoietin (rHuEPO) is regarded as a life-saving biotherapeutic in case of acute disease associated anemia. Several commercially available rHuEPO drug products are present in the market for ...
REAL208, a Liposome-based Formulation of Phosphodiesterase Inhibitor, Protects Acute Kidney Deficiency in Mice [0.03%]
基于脂质体的磷酸二酯酶抑制剂REAL208对小鼠急性肾损伤的保护作用研究
Jui-Chi Tsai,Yi-Wen Lin,Chun-Yao Huang et al.
Jui-Chi Tsai et al.
Objective: Acute kidney injury (AKI) is a life-threatening condition characterized by inflammation, oxidative stress, and tubular cell apoptosis for which no specific pharmacological therapy currently exists. Dipyridamole...