Opportunities in an Evolving Pharmaceutical Development Landscape: Product Differentiation of Biopharmaceutical Drug Products [0.03%]
变革中的制药开发格局下的产品差异化机遇：生物药产品的特点分析
Andrea Allmendinger
Andrea Allmendinger
The current perspective reviews the biopharmaceutical market until end of 2020 and highlights the transforming biopharmaceutical landscape during the recent decade. In particular, the rise of biosimilars and the development of new therapeut...
Tonglei Li
Tonglei Li
Published Erratum
Pharmaceutical research. 2021 Apr;38(4):737. DOI:10.1007/s11095-021-03031-x 2021
Pharmaceutical Excipients Enhance Iron-Dependent Photo-Degradation in Pharmaceutical Buffers by near UV and Visible Light: Tyrosine Modification by Reactions of the Antioxidant Methionine in Citrate Buffer [0.03%]
抗氧剂半胱氨酸和酪氨酸在柠檬酸盐缓冲液中的降解：近紫外和可见光照射下的铁依赖性光降解作用
Natalia Subelzu,Christian Schöneich
Natalia Subelzu
Purpose: To evaluate the effect of excipients, including sugars and amino acids, on photo-degradation reactions in pharmaceutical buffers induced by near UV and visible light. ...
Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration [0.03%]
用于预临床研究的无定形固体分散体助溶剂铸膜成膜技术：体外及体内研究探索
Laura I Mosquera-Giraldo,Maria Donoso,Kevin Stefanski et al.
Laura I Mosquera-Giraldo et al.
Purpose: The use of two solvent-casted film methods to select optimal polymer compositions for amorphous solid dispersions prepared to support preclinical pharmacokinetic and toxicology studies is described. ...
Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption [0.03%]
通过检查吸收变化来调查肠道转运蛋白在利伐沙班 disposition 中的作用
Wen Kou,Jasleen K Sodhi,Xin&#x;an Wu et al.
Wen Kou et al.
Purpose: The involvement of the intestinally expressed xenobiotic transporters P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) have been implicated in rivaroxaban disposition based on in vitro studies, s...
Dried Blood Spot Technique Applied in Therapeutic Drug Monitoring of Anticancer Drugs: a Review on Conversion Methods to Correlate Plasma and Dried Blood Spot Concentrations [0.03%]
抗肿瘤药物治疗药物监测中应用干血点技术的转换方法以关联血浆和干血点浓度的相关研究综述
Valentina Iacuzzi,Bianca Posocco,Martina Zanchetta et al.
Valentina Iacuzzi et al.
Background: Anticancer drugs are notoriously characterized by a low therapeutic index, the introduction of therapeutic drug monitoring (TDM) in oncologic clinical practice could therefore be fundamental to improve treatme...
BSA/Silver Nanoparticle-Loaded Hydrogel Film for Local Photothermal Treatment of Skin Cancer [0.03%]
用于局部光热治疗皮肤癌的BSA/银纳米粒子负载水凝胶膜
Reeju Amatya,Seungmi Hwang,Taehoon Park et al.
Reeju Amatya et al.
Purpose: To develop a hydrogel film containing bovine serum albumin (BSA)-coated silver nanoparticles (BSA/AgNP) and evaluate its applicability for topical photothermal treatment (PTT) of skin cancer. ...
Characterization of Biological Material Adsorption to the Surface of Nanoparticles without a Prior Separation Step: a Case Study of Glioblastoma-Targeting Peptide and Lipid Nanocapsules [0.03%]
无需预分离步骤表征生物分子吸附到纳米颗粒表面的特性：以胶质母细胞瘤靶向肽和脂质纳米囊为研究对象
Claire Gazaille,Marion Sicot,Marthe Akiki et al.
Claire Gazaille et al.
Purpose: Current preclinical therapeutic strategies involving nanomedicine require increasingly sophisticated nanosystems and the characterization of the complexity of such nanoassemblies is becoming a major issue. Accura...
Effect of pH on Iontophoretic Transport of Pramipexole Dihydrochloride across Human Epidermal Membrane [0.03%]
pH对普拉克索二盐酸盐经皮离子导入的影响研究
Kamchai Saepang,S Kevin Li,Doungdaw Chantasart
Kamchai Saepang
Purpose: Drugs with higher molecular charges generally show higher flux enhancement when electromigration is the main mechanism in transdermal iontophoresis. This study evaluated the effect of decreasing the formulation p...
Chiral Transplacental Pharmacokinetics of Fexofenadine: Impact of P-Glycoprotein Inhibitor Fluoxetine Using the Human Placental Perfusion Model [0.03%]
氟西汀介导的人胎盘灌流模型中左旋西替利嗪转运的胎盘手性药代动力学研究
Leonardo Pinto,Priya Bapat,Fernanda de Lima Moreira et al.
Leonardo Pinto et al.
Purpose: Fexofenadine is a well-identified in vivo probe substrate of P-glycoprotein (P-gp) and/or organic anion transporting polypeptide (OATP). This work aimed to investigate the transplacental pharmacokinetics of fexof...