Characterization of Grinding-Induced Subvisible Particles and Free Radicals in a Freeze-Dried Monoclonal Antibody Formulation [0.03%]
冻干单克隆抗体制剂中研磨诱导的亚可见颗粒和自由基的表征
Zhen-Yi Jing,Guo-Li Huo,Min-Fei Sun et al.
Zhen-Yi Jing et al.
Purposes: The primary objectives of this study were to investigate the degradation mechanisms of freeze-dried monoclonal antibody (mAb) formulations under mechanical grinding, assess the sensitivity and suitability of var...
Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size [0.03%]
给药途径和颗粒大小对mRNA脂质纳米粒体内分布及非线性基因表达的影响
Jiaxing Di,Zhili Du,Kangzeng Wu et al.
Jiaxing Di et al.
Purpose: Lipid nanoparticles (LNPs) are widely utilized as means to deliver mRNA molecules. However, metric connections between biodistribution and pharmacokinetics (PK) of the nanoparticle carrier and transgene expressio...
Testing Precision Limits of Neural Network-Based Quality Control Metrics in High-Throughput Digital Microscopy [0.03%]
基于神经网络的质量控制度量在高通量数字显微镜中的精度限制的测试
Christopher P Calderon,Dean C Ripple,Charudharshini Srinivasan et al.
Christopher P Calderon et al.
Objective: Digital microscopy is used to monitor particulates such as protein aggregates within biopharmaceutical products. The images that result encode a wealth of information that is underutilized in pharmaceutical pro...
A New Saquinavir Mesylate-Sodium Decyl Sulfate Salt Discovered by Serendipity during an Anomalous Dissolution Test [0.03%]
偶然发现的新西那瓦甲磺酸-月桂醇硫酸钠盐组合物
Cinira Fandaruff,Thiago Caon,Andrea Mariela Araya-Sibaja et al.
Cinira Fandaruff et al.
Purpose: To understand the anomalous behavior of Saquinavir Mesylate (SQVM) in sodium decyl sulfate (SDS) medium during a dissolution test through a crystallographic analysis of the crystal obtained. As a result, it will ...
Multiphysics Modelling and Simulation of Thrombolysis via Activated Platelet-Targeted Nanomedicine [0.03%]
活性血小板靶向纳米药物溶栓的多物理场模型及仿真研究
Boram Gu,Yu Huang,Emily Louise Manchester et al.
Boram Gu et al.
Purpose: This study establishes a multiphysics simulation platform for both conventional and targeted thrombolysis using tissue plasminogen activator (tPA). Based on our computational results, the effects of therapeutic p...
Development of a Physiologically-Based Pharmacokinetic Model for Whole-Body Disposition of MMAE Containing Antibody-Drug Conjugate in Mice [0.03%]
开发包含MMAE的抗体药物偶联物在小鼠体内全身分布的生理药代动力学模型
Hsuan-Ping Chang,Zhe Li,Dhaval K Shah
Hsuan-Ping Chang
Purpose: To quantitate and mathematically characterize the whole-body pharmacokinetics (PK) of different ADC analytes following administration of an MMAE-conjugated ADC in tumor-bearing mice. ...
Towards a Better Understanding of the Post-Gastric Behavior of Enteric-Coated Formulations [0.03%]
肠溶制剂胃排空后的行为研究进展
Miklós Tamás Katona,Melinda Kakuk,Réka Szabó et al.
Miklós Tamás Katona et al.
Purpose: The aim of our work was to develop a biorelevant dissolution method for a better understanding of the in vivo performance of delayed-release tablet formulations. ...
Md Nurul Huda,Md Nurunnabi
Md Nurul Huda
Exosomes are cell-derived components composed of proteins, lipid, genetic information, cytokines, and growth factors. They play a vital role in immune modulation, cell-cell communication, and response to inflammation. Immune modulation has ...
Impact of Surfactants on the Performance of Clopidogrel-Copovidone Amorphous Solid Dispersions: Increased Drug Loading and Stabilization of Nanodroplets [0.03%]
表面活性剂对氯吡格雷-柯多伐酮无定形固态分散体性能的影响：增加药物载药量和纳米液滴稳定化
Clara E Correa Soto,Yi Gao,Anura S Indulkar et al.
Clara E Correa Soto et al.
Purpose: Surfactants are increasingly being added to amorphous solid dispersion (ASDs) formulations to enhance processability and release performance. The goal of the current work was to investigate the impact of cationic...
Translational Modeling of Chloroquine and Hydroxychloroquine Dosimetry in Human Airways for Treating Viral Respiratory Infections [0.03%]
用于治疗病毒性呼吸道感染的人体气道氯喹和羟氯喹剂量模型的转化研究
Aditya R Kolli,Florian Calvino-Martin,Julia Hoeng
Aditya R Kolli
Purpose: Chloroquine and hydroxychloroquine are effective against respiratory viruses in vitro. However, they lack antiviral efficacy upon oral administration. Translation of in vitro to in vivo exposure is necessary for ...