Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next-Generation Therapies [0.03%]
基于肽的纳米粒子在神经退行性疾病治疗中的应用研究
V R Ranjitha,Anil Kumar,Prashantha Kaalappa
V R Ranjitha
The convergence of peptides and nanoparticles through bionanoconjugation has emerged as a transformative strategy to address the persistent challenges in treating neurodegenerative disorders. Peptides, particularly short sequences (< 45 ami...
Design and In Vitro Evaluation of Gambogic Acid-Conjugated Stearic Acid Solid Lipid Nanoparticles for Transferrin Receptor-Mediated Drug Delivery [0.03%]
gambogic酸-连接硬脂酸固体脂质纳米颗粒的设计与体外评价用于转铁蛋白受体介导的药物输送
Raghu Ganugula,Yirivinti Hayagreeva Dinakar,Anjali Kurse et al.
Raghu Ganugula et al.
Solid lipid nanoparticles (SLNs) have garnered significant interest for their safety and efficacy, especially following the success of COVID-19 mRNA vaccines. This study presents the synthesis and characterization of a novel stearic acid (S...
Improving the CQAs and Lyophilization Process Efficiency of Freeze-dried Monoclonal Antibody Drug Products Using Controlled Ice Nucleation Technology [0.03%]
运用控制冰核化技术改善冻干单克隆抗体药物产品的关键质量属性及冷冻干燥工艺效率
Yao Chen,Mary Kleppe,Saurav Sharma et al.
Yao Chen et al.
Purpose: The objective of this research was to explore the application of controlled ice nucleation (CN) technology to enhance the critical quality attributes (CQAs) and manufacturing efficiency of freeze-dried monoclonal...
Multifunctional Engineering of Exosomes for Precision Therapeutics: Strategies for Targeted Delivery, Barrier Evasion, and Clinical Translation [0.03%]
多功能工程外泌体的精准治疗策略：靶向递送、屏障规避及临床转化
Shea Riona Mendonca,Pragathi Devanand Bangera,Mahesha Keerikkadu et al.
Shea Riona Mendonca et al.
Exosomes (EXM), cell-secreted nanoscale vesicles, are now used as promising tools for therapeutic protein, nucleic acid, and small molecule delivery. However, various challenges, such as rapid immune system clearance, ineffective cargo load...
Population Pharmacokinetics of Intravenous Levetiracetam in Neurosurgical Patients: Dosage Optimization Based on CrCl and Mannitol Use [0.03%]
神经外科患者的静脉注射左乙拉西坦药代动力学：基于CrCl和甘露醇使用的剂量优化
Jinwei Fan,Jinhui Xu,Xianglong Chen et al.
Jinwei Fan et al.
Objective: Conventional low-dose levetiracetam (LEV) for post-neurosurgical seizure prophylaxis often yields subtherapeutic serum levels. This study characterized the population pharmacokinetics (PPK) of intravenous LEV t...
Evaluation of Mannitol's Crystallization Impact on the Secondary Structure of Spray-Dried recombinant human Growth Hormone (rhGH) Formulations [0.03%]
甘露醇结晶对喷雾干燥重组人生长激素(rhGH)制剂二级结构影响的评估
Ravi Vamsi Peri,Harsh Anchan,Kamal Jonnalagadda et al.
Ravi Vamsi Peri et al.
Objective: The development of protein formulations is grappled by the complexity of maintaining protein integrity during the arduous formulation process. While several excipients have been employed for the stabilization o...
Pharmaceutical 3D Printing for Psychiatric Medications: Advanced Innovations in Taste Masking and Personalized Oral Drug Delivery [0.03%]
精神病药物的制药3D打印：掩味和个性化口服给药的先进创新技术
Praveen H S,Kiran Kumar G B,Prasiddhi Naik et al.
Praveen H S et al.
Purpose: This review aims to examine the impact of three-dimensional (3D) printing technologies on enhancing psychiatric pharmacotherapy through facilitating personalized and patient-centered drug delivery. This research ...
Drum Filling of Thin-Film Freeze-Dried Monoclonal Antibody Powder in UniDose Powder Nasal Spray System [0.03%]
UniDose粉鼻喷雾系统中单克隆抗体冻干粉末薄层的鼓包填充研究
Michael A Sandoval,Miguel O Jara,Thomas Henry et al.
Michael A Sandoval et al.
Purpose: Intranasal delivery of monoclonal antibodies (mAb) offers an attractive approach for preventing or treating respiratory viral infections. Previously, we showed that thin-film freeze-dried powder (TFFD powder) of ...
Co-encapsulation of an AKT Inhibitor Enhances the Tumor-cell Selectivity of STING Agonists in Co-delivery Liposomes [0.03%]
共封装AKT抑制剂可增强共递送脂质体中STING激动剂的肿瘤细胞选择性
Ziyu Ge,Qiang Zhang,Yuming Wang et al.
Ziyu Ge et al.
Objective: The therapeutic potential of STING agonists in cancer immunotherapy is hindered by poor tumor selectivity, resulting in systemic inflammation. Conventional targeted delivery strategies rely on cell-surface mark...
A Proposal for Alternative FDA Bioequivalence Criteria for Narrow Therapeutic Index Drug Products to Support Future Harmonization [0.03%]
一个针对窄治疗指数药物生物等效性标准的替代FDA准则的提议以支持未来的国际协调工作
Wanjie Sun,Donald Schuirmann,Fairouz Makhlouf et al.
Wanjie Sun et al.
Purpose: Establishing bioequivalence (BE) for narrow therapeutic index (NTI) drugs presents unique challenges due to the delicate balance between therapeutic efficacy and toxicity. Recognizing the critical nature of NTI d...