Impurities and Potential Immunogenicity Associated With Follow-on and Compounded Glucagon-like Peptide-1 Receptor Agonists [0.03%]
与后上市及自制的GLP-1受体激动剂相关杂质和潜在免疫原性
Katharina L Kopp,Kasper Lamberth,Ole Schelde et al.
Katharina L Kopp et al.
Purpose: To assess impurity profiles/potential immunogenicity of multiple samples of follow-on or compounded products for two glucagon-like peptide-1 receptor agonists (GLP-1 RAs): semaglutide and liraglutide. ...
Syn-Anti Conformational Equilibrium of Indomethacin: A Combined NOESY and Quantum Chemical Study [0.03%]
吲哚美辛的顺式-反式构象平衡：NOESY与量子化学的联合研究
Aleksey Kovalev,Konstantin Belov,Yoshio Barrera et al.
Aleksey Kovalev et al.
Purpose: To elucidate the conformational equilibrium of Indomethacin in solution and to establish its relationship with solvent environment and solid-state polymorphism. ...
Pharmacokinetics and Brain Distribution of a Purine-Derived Neuroprotective Agent after Intranasal Administration in Neonatal Rats with Hypoxic-Ischemic Brain Injury [0.03%]
鼻腔给药嘌呤类神经营养剂的药代动力学及缺氧缺血性脑损伤新生大鼠脑内分布研究
Auriane Maïza,Clemence Disdier,Amalia Tsintzou et al.
Auriane Maïza et al.
Purpose: Hypoxic-ischemic (HI) brain injury results in death and lifelong disabilities in newborns. Pharmaceutical agents are not available to treat HI brain injury. We reported that intraperitoneal (IP) BRT_002 is neurop...
Development of an In Vitro Permeation Test Framework For Naloxone Hydrochloride Intranasal Spray: Establishing IVIVR for Bioequivalence Assessment [0.03%]
盐酸纳洛酮鼻喷雾剂体外渗透试验体系的建立及与体内相关性研究以支持仿制药生物等效评价
Tasmin Ara Sultana,Manar Al-Ghabeish,Steven Chopski et al.
Tasmin Ara Sultana et al.
Purpose: Intranasal (IN) naloxone achieves rapid systemic exposure necessary for effective opioid overdose reversal; yet establishing bioequivalence (BE) for fast-acting drug-device combination products remains challengin...
Yihua Bruce Yu,Rutendo Kuwana
Yihua Bruce Yu
In the current healthcare system, patients are, for the most part, passive consumers of medicines. Patients far outnumber healthcare workers. If patients could be empowered to actively participate in improving medicine safety, public health...
Integrating Clinical Evidence with PBPK Modeling to Assess PPI-Clopidogrel-CYP2C19 Interactions in Chinese ACS Patients [0.03%]
基于临床证据的PBPK模型在评价氯吡格雷与中药相互作用中的应用：以ACS患者为例
Ya-Xin Liu,Yun Kuang,Jun-Long Ma et al.
Ya-Xin Liu et al.
Purpose: The interaction between proton pump inhibitors (PPIs) and clopidogrel in acute coronary syndrome (ACS) patients is mediated by CYP2C19 genetic variants. This study quantitatively assessed their CYP2C19 genotype-d...
Discovering the Differences of the Individual Batches of API and its Polymorphs Using Hansen Solubility Parameters [0.03%]
运用Hansen溶度参数发现活性药物成分及其多晶型批次间的差异
Matúš Švichký,Ondřej Sauer,Eva Petříková et al.
Matúš Švichký et al.
Purpose: Physicochemical stability of drug products depends on excipient-API (active pharmaceutical ingredient) compatibility, where interfacial interactions at the particle surface can initiate degradation pathways and s...
Identification of Microbiome Associations with Tacrolimus Pharmacokinetics in Adult Hematopoietic Cell Transplantation Using Population Pharmacokinetic and Machine Learning [0.03%]
人群药代动力学和机器学习在成人造血细胞移植中鉴定微生物组与他克莫司药代动力学之间的关系
Moataz E Mohamed,Shen Cheng,Christopher Staley et al.
Moataz E Mohamed et al.
Purpose: Tacrolimus (TAC) is known for its high pharmacokinetic variability which cannot be fully explained by pharmacogenomic (PGx) and clinical variables. We identified gut microbiome associated with TAC pharmacokinetic...
Mechanistic Insights into Membrane- and Release-Controlled Drug Permeation from Ketoprofen-Lidocaine Eutectic Fluids [0.03%]
从双氯酚丁卡因共熔流体中关于膜介导和控制释放的药物渗透的见解
Masahiro Sugino,Yui Igarashi,Suzuka Shiina et al.
Masahiro Sugino et al.
Purpose: Eutectic fluids (EFs) are liquid pharmaceutical systems formed through intermolecular interactions between their components. This study aims to clarify the mechanistic basis of membrane- and release-controlled dr...
Hydrogel-Mediated Delivery of Drug Nanocarriers in the Oedematous Postoperative Brain [0.03%]
水肿术后脑组织中水凝胶介导的药物纳米载体递送
Noel Benton,Wenbo Zhan
Noel Benton
PURPOSE AND OBJECTIVES: Hydrogel-nanocarrier systems have emerged as a clinically implementable strategy to reduce glioblastoma recurrence following surgery. Despite demonstrated feasibility, the influence of intrinsic tissue and nanocarrie...