Jihao Zhou,Zhaohui Qin,Sara K Quinney et al.
Jihao Zhou et al.
An innovative probabilistic rule is proposed to predict the clinical significance or clinical insignificance of DDI. This rule is coupled with a hierarchical Bayesian model approach to summarize substrate/inhibitor's PK models from multiple...
David Lunn,Nicky Best,David Spiegelhalter et al.
David Lunn et al.
We introduce a method for preventing unwanted feedback in Bayesian PKPD link models. We illustrate the approach using a simple example on a single individual, and subsequently demonstrate the ease with which it can be applied to more genera...
Automated covariate selection and Bayesian model averaging in population PK/PD models [0.03%]
群体PK/PD模型中的协变量自动选择和Bayesian平均模型方法
David J Lunn
David J Lunn
We illustrate the use of 'reversible jump' MCMC to automate the process of covariate selection in population PK/PD analyses. The output from such an approach can be used not only to determine the 'best' covariate model for each parameter, b...
Non-Bayesian knowledge propagation using model-based analysis of data from multiple clinical studies [0.03%]
基于多临床数据的非贝叶斯知识传播模型分析
Jakob Ribbing,Andrew C Hooker,E Niclas Jonsson
Jakob Ribbing
The ultimate goal in drug development is to establish the manner of safe and efficacious administration to patients. To achieve this in an efficient way the information contained in the clinical studies should contribute to the increasing p...
Early identification of drug-induced impairment of gastric emptying through physiologically based pharmacokinetic (PBPK) simulation of plasma concentration-time profiles in rat [0.03%]
基于生理的药代动力学(PBPK)模拟预测药物致胃排空障碍的早期评价研究
Sheila Annie Peters,Leif Hultin
Sheila Annie Peters
Inhibition of gastric emptying rate can have adverse effects on the absorption of food and nutrients. The absorption phase of the plasma concentration-time profile of a compound administered orally to pre-clinical species reflects among oth...
Impact of censoring data below an arbitrary quantification limit on structural model misspecification [0.03%]
任意量化限下的数据审查对结构模型错误指定的影响分析
Wonkyung Byon,Courtney V Fletcher,Richard C Brundage
Wonkyung Byon
It is not uncommon in pharmacokinetic (PK) studies that some concentrations are censored by the bioanalytical laboratory and reported qualitatively as below the lower limit of quantification (LLOQ). Censoring concentrations below the quanti...
Development of a human physiologically based pharmacokinetic (PBPK) model for inorganic arsenic and its mono- and di-methylated metabolites [0.03%]
用于描述无机砷及其单甲基化和双甲基化的代谢产物的人体生理药代动力学(PBPK)模型的发展研究论文
Hisham A El-Masri,Elaina M Kenyon
Hisham A El-Masri
A physiologically-based pharmacokinetic (PBPK) model was developed to estimate levels of arsenic and its metabolites in human tissues and urine after oral exposure to arsenate (As(V)), arsenite (As(III)) or organoarsenical pesticides. The m...
A mechanistic model for the sex-specific response to nalbuphine and naloxone in postoperative pain [0.03%]
纳布啡和纳洛酮术后镇痛的性别特异性反应机制模型
Smita Kshirsagar,Robert Gear,Jon Levine et al.
Smita Kshirsagar et al.
We develop a mechanistic model for post-operative pain and apply it to describe the pharmacodynamic effects of the kappa-opioids nalbuphine and naloxone administered either alone or in combination in patients after surgical removal of one o...
Randomized Controlled Trial
Journal of pharmacokinetics and pharmacodynamics. 2008 Feb;35(1):69-83. DOI:10.1007/s10928-007-9076-y 2008