Correction: Tracer kinetic modeling of a 14 kDa anti-CD8 PET tracer (2C8v144) for in vivo estimation of CD8 expression in tissue and blood, binding affinity, and total body receptor occupancy [0.03%]
纠正：用于体内估算组织和血液中CD8表达、结合亲和力和全身受体占有率的14kDa抗-CD8 PET示踪剂（2C8v144）的动力学建模
Ruediger E Port,C Andrew Boswell,Annie Ogasawara et al.
Ruediger E Port et al.
Diffusion models for virtual populations and pharmacometric simulations [0.03%]
药物扩散模型及药代动力学模拟研究虚拟人群的方法
Prathamesh Kishor Gadgil,Shamith Manjunath Poojari,Murali Ramanathan
Prathamesh Kishor Gadgil
To evaluate diffusion model-based artificial intelligence approaches for generating virtual populations with physiological determinants of drug dosing (PDODD) and pharmacokinetic (PK) profiles. A denoising diffusion probabilistic model (DDP...
Construction of a translational whole-body physiologically based pharmacokinetic model to investigate the biodistribution of lipid nanoparticle-based mRNA therapeutics for intracellular protein targets [0.03%]
构建用于研究基于脂质纳米颗粒的mRNA疗法在细胞内蛋白质靶点分布的全身生理药代动力学模型
Kenji Miyazawa,Hojjat Bazzazi,Wei Gao
Kenji Miyazawa
Lipid nanoparticle (LNP)-based messenger RNA (mRNA) therapeutics enable in vivo production of diverse protein modalities, but their translation is complicated by multiscale pharmacokinetics encompassing tissue transport, cellular uptake, an...
External validation of population pharmacokinetic models of adalimumab in adult patients with inflammatory bowel disease: towards model-informed precision dosing [0.03%]
外部验证成年炎症性肠病患者阿达木单抗群体药代动力学模型的精准给药能力
Irene Aguilo-Lafarga,Tonet Serés-Noriega,Vicente Gimeno-Ballester et al.
Irene Aguilo-Lafarga et al.
Inflammatory bowel disease (IBD) has variability in the pharmacokinetics of adalimumab, which may predispose patients to subtherapeutic concentrations, therapeutic failure, and/or drug immunogenicity. Population pharmacokinetic (popPK) mode...
Ehrlich occupancy time: beyond [Formula: see text] to a complete residence time framework [0.03%]
厄利希占据时间：从[公式见正文]到完整停留时间框架
Justin Eilertsen,Santiago Schnell,Sebastian Walcher
Justin Eilertsen
Drug-target occupancy time-the cumulative duration a target remains bound-critically influences therapeutic efficacy. While Copeland's widely-used residence time ([Formula: see text]) emphasizes dissociation kinetics, it neglects associatio...
Strategies for pediatric dose derivation from population pharmacokinetic models [0.03%]
人群药代动力学模型的儿科剂量推导策略
Andreas Krause,Géraldine Cellière
Andreas Krause
Health authorities worldwide require clinical studies in children to ensure scientifically rigorous and consistent dosing. Before pediatric data are available, model-based methods provide a scientific and reproducible way to determine doses...
On the structural identifiability of nonlinear models of ligand binding dynamics [0.03%]
关于配体结合动力学非线性模型结构可识别性的研究
Carla White,Vivi Rottschäfer,Lloyd Bridge
Carla White
Quantification of drug-cell interactions and subsequent cellular responses by using experimental data together with mathematical models of assumed binding and signalling schematics is vital to many research programmes; data fitting provides...
Shufang Liu,Ekram Ahmed Chowdhury,Shengjia Wu et al.
Shufang Liu et al.
Adeno-associated virus (AAV) mediated monoclonal antibody (mAb) expression in the brain represents an exciting one-and-done therapeutic option for many central nervous system (CNS) disorders that are hard to treat following systemic mAb adm...
A simple algebraic expression can determine if a drug's clearance is non-specific or target-mediated [0.03%]
一个简单的代数表达式可以确定药物清除率是非特异性的还是由靶点介导的
Liam V Brown,Alberto Ippolito,Mark Penney et al.
Liam V Brown et al.
Target-mediated drug distribution (TMDD) is typically classified by accelerated removal of drug after serum concentration drops below a critical level. Susceptible drugs would be dosed to a schedule that maintains exposure above this level,...
Differential expression of monoclonal antibody in rat brain following systemic and local administration of AAV [0.03%]
经系统和局部给药后AAV在大鼠脑中单克隆抗体的差异表达
Ekram Ahmed Chowdhury,Guy Meno-Tetang,Shufang Liu et al.
Ekram Ahmed Chowdhury et al.
Adeno-associated virus (AAV) mediated monoclonal antibody (mAb) expression in the central nervous system (CNS) constitutes a promising approach for treating various CNS disorders. However, a comprehensive understanding of AAV biodistributio...