An integrated pharmacokinetic-pharmacodynamic model for an Aurora kinase inhibitor [0.03%]
血管紧张素受体拮抗剂氯沙坦的药代动力学/药效动力学模型研究
Hiroko Kamei,Robert C Jackson,Daniella Zheleva et al.
Hiroko Kamei et al.
The spindle assembly checkpoint is a cell cycle surveillance mechanism that ensures the proper separation of chromosomes prior to cell division at mitosis. Aurora kinases play critical roles in mitotic progression and hence small-molecule i...
Target-mediated drug disposition model for drugs that bind to more than one target [0.03%]
多个靶点结合药物的靶介导药物处置模型
Leonid Gibiansky,Ekaterina Gibiansky
Leonid Gibiansky
Until recently, most therapeutic monoclonal antibodies (mAb) were designed to bind only one target. However, several existing mAbs bind to soluble and membrane forms of the same receptor. Moreover, design of bi-specific and multi-specific p...
Lumping of physiologically-based pharmacokinetic models and a mechanistic derivation of classical compartmental models [0.03%]
基于生理的药代动力学模型的合并及经典室模型的机制派生
Sabine Pilari,Wilhelm Huisinga
Sabine Pilari
In drug discovery and development, classical compartment models and physiologically based pharmacokinetic (PBPK) models are successfully used to analyze and predict the pharmacokinetics of drugs. So far, however, both approaches are used ex...
A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080 [0.03%]
一种抗血管生成药物E7080治疗的癌症病人高血压和蛋白尿模型
Ron J Keizer,Anubha Gupta,Melvin R Mac Gillavry et al.
Ron J Keizer et al.
Hypertension and proteinuria are commonly observed side-effects for anti-angiogenic drugs targeting the VEGF pathway. In most cases, hypertension can be controlled by prescription of anti-hypertensive (AH) therapy, while proteinuria often r...
A latent variable approach for modeling categorical endpoints among patients with rheumatoid arthritis treated with golimumab plus methotrexate [0.03%]
一种用于类风湿关节炎患者戈利木单抗联合甲氨蝶呤治疗的分类终点模型的潜在变量方法
Chuanpu Hu,Zhenhua Xu,Mahboob U Rahman et al.
Chuanpu Hu et al.
The need for accurate exposure-response modeling is critical in the drug development process. Few methods are available for linking discrete endpoints, especially ordered categorical variables, to mechanistic (e.g., indirect response) model...
Assessing circadian rhythms in propofol PK and PD during prolonged infusion in ICU patients [0.03%]
评估ICU患者长时间输注异丙酚药代动力学和药效学的昼夜节律
Agnieszka Bienert,Krzysztof Kusza,Katarzyna Wawrzyniak et al.
Agnieszka Bienert et al.
This study evaluates possible circadian rhythms during prolonged propofol infusion in patients in the intensive care unit. Eleven patients were sedated with a constant propofol infusion. The blood samples for the propofol assay were collect...
PAVA: physiological and anatomical visual analytics for mapping of tissue-specific concentration and time-course data [0.03%]
生理和解剖可视化分析法（PAVA）映射组织特异性浓度及动态数据
Michael-Rock Goldsmith,Thomas R Transue,Daniel T Chang et al.
Michael-Rock Goldsmith et al.
We describe the development and implementation of a Physiological and Anatomical Visual Analytics tool (PAVA), a web browser-based application, used to visualize experimental/simulated chemical time-course data (dosimetry), epidemiological ...
Davide Verotta
Davide Verotta
While an increasing number of fractional order integrals and differential equations applications have been reported in the physics, signal processing, engineering and bioengineering literatures, little attention has been paid to this class ...
Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice [0.03%]
曲妥珠单抗-美坦辛免疫偶联物的疗效模型研究（荷瘤小鼠）
Nelson L Jumbe,Yan Xin,Douglas D Leipold et al.
Nelson L Jumbe et al.
Trastuzumab-DM1 (T-DM1) is a novel antibody-drug conjugate under investigation for the treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. One challenge in oncologic drug development is determinin...
A two-compartment effect site model describes the bispectral index after different rates of propofol infusion [0.03%]
双隔室效应位点模型可解释不同剂量丙泊酚输注后的双频谱指数变化
Marcus A Björnsson,Ake Norberg,Sigridur Kalman et al.
Marcus A Björnsson et al.
Different estimates of the rate constant for the effect site distribution (k(e0)) of propofol, depending on the rate and duration of administration, have been reported. This analysis aimed at finding a more general pharmacodynamic model tha...
Randomized Controlled Trial
Journal of pharmacokinetics and pharmacodynamics. 2010 Jun;37(3):243-55. DOI:10.1007/s10928-010-9157-1 2010