APOE4 genotypes and the trajectory of biomarkers, neuroimaging, and cognitive measures in Alzheimer's Disease: A mixed-effects disease progression model [0.03%]
APOE4基因型和阿尔茨海默病生物标志物、神经影像学和认知测量指标的轨迹：混合效应疾病进展模型
Carson Essenburg,Murali Ramanathan
Carson Essenburg
Background: The ε4 allele of the apolipoprotein E gene (APOE4) is a major risk factor for developing sporadic Alzheimer's disease (AD). APOE4 homozygosity has been recently proposed as the defining signature of a genetic...
Sample size determination for cardiodynamic ECG assessment using the Concentration-QTc analysis method [0.03%]
基于浓度-QTc分析方法的心动力ECG评估的样本量估算方法研究
Hongqi Xue,Georg Ferber,Ellen Freebern et al.
Hongqi Xue et al.
Concentration-QTc (C-QTc) analysis was accepted to serve as an alternative to the by-time point analysis with intersection-union test (IUT) as the primary basis for decisions to classify the arrhythmogenic risk of a drug by ICH E14 Q&As (R3...
Pharmacometrics education for all by overcoming language barriers to enhance global collaboration [0.03%]
克服语言障碍进行药代动力学教育，以增强全球合作能力
Sonia Khier,Anna H-X P Chan Kwong,Maud Harnichard et al.
Sonia Khier et al.
Proficiency in English is essential in scientific disciplines; however, it is unevenly distributed globally, creating barriers for those with limited training. Research in neuroscience supports the benefits of teaching in a student's native...
Correction: Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics [0.03%]
基于生理的药代动力学在靶向治疗寡核苷酸跨物种转化模型中的修正应用研究
Abdallah Derbalah,Felix Stader,Cong Liu et al.
Abdallah Derbalah et al.
Lessons learned from QT prolongation risk assessment for antibody-drug conjugates in oncology [0.03%]
抗体偶联药物抗肿瘤药学研究中延长QT间期的风险评估经验总结
Shruti D Shah,Roxanne C Jewell,Geraldine Ferron-Brady et al.
Shruti D Shah et al.
Antibody-drug conjugates (ADCs) are advanced cancer therapeutics that link monoclonal antibodies to cytotoxic drugs, enhancing targeted delivery to tumors. Since the FDA's first ADC approval in 2000, 14 ADCs have received approval to date (...
Joanna Parkinson,Corina Dota,Dinko Rekić
Joanna Parkinson
Concentration-QTc (C-QTc) analysis is a model-based method widely used to assess the impact of drugs on QT interval duration. C-QTc modelling was enabled to be used after the publication of the International Council for Harmonisation (ICH) ...
Quantifying clinical and genetic factors influencing rate and severity of autosomal dominant tubulointerstitial kidney disease progression [0.03%]
量化临床和遗传因素对常染色体显性肾小管间质性疾病进展速度和严重程度的影响
Shyam S Ramesh,Mark Rogge,Kendrah O Kidd et al.
Shyam S Ramesh et al.
Autosomal dominant tubulointerstitial kidney disease (ADTKD), caused by mutations in UMOD and MUC1 genes, leads to tubular damage and fibrosis, ultimately resulting in kidney failure (KF). This study investigated clinical and genetic factor...
A semi-mechanistic population pharmacokinetic-pharmacodynamic model to assess downstream drug-target effects on erythropoiesis [0.03%]
半机械人群药物代谢动力学-药物动力学模型 评估下游药物靶点对红细胞生成的影响
S Viktor Rognås,Franziska Schaedeli Stark,Maddalena Marchesi et al.
S Viktor Rognås et al.
Erythropoiesis is a complex process that results in the production of erythrocytes from hematopoietic stem cells in the bone marrow. This work aimed to develop a population pharmacokinetic-pharmacodynamic (PKPD) model describing erythropoie...
Identification of oncology pharmacokinetic drivers through in vitro experiments and computational modeling [0.03%]
基于体外实验和计算模型的肿瘤药物动力学驱动因素识别
Britton Boras,Eric C Greenwald,Yuli Wang et al.
Britton Boras et al.
Drug discovery balances many factors as it identifies compounds for clinical testing, including compound efficacy, safety, pharmacokinetic (PK) properties, commercial feasibility, competitive positioning, and organizational pressures to mov...