Utility of a physiologically-based pharmacokinetic model for investigating time-dependent variability in the fetal-to-maternal plasma concentration ratio of digoxin [0.03%]
基于生理的药代动力学模型在探究地高辛胎盘转运时间依赖性变化中的应用价值
Kanoko Okuba,Kenji Ikeda
Kanoko Okuba
The purpose of this study was to elucidate the mechanisms underlying the wide variability in fetal-to-maternal (F/M) concentration ratios of digoxin by comprehensively characterizing maternal and fetal pharmacokinetics using a physiological...
Modeling, Simulation, and Extrapolation to Optimize Pediatric Development Plan: Sarilumab Polyarticular-Course juvenile arthritis Application [0.03%]
模拟、外推优化儿科研发方案：萨利鲁玛治疗多关节型幼年特发性关节炎案例分析
Christine Xu,Mei Zhang,Ying Liu et al.
Christine Xu et al.
Polyarticular-course juvenile idiopathic arthritis (pcJIA) is a chronic condition that manifests before the age of 16 years, with pathology similar to that of adult rheumatoid arthritis (RA). Sarilumab is an interleukin-6 receptor inhibitor...
Assessing the impact of bacterial heterogeneity on bacteriophage population dynamics [0.03%]
评估细菌异质性对噬菌体种群动态的影响
Massinissa Beldjenna,Jérémie Guedj,J G Coen van Hasselt et al.
Massinissa Beldjenna et al.
Bacteriophages follow complex replication dynamics in codependence with their host cells. The corresponding dynamics are usually described with three key parameters: the adsorption rate , the burst size and the latent period . Single-cell ...
On the existence conditions of interaction indices in response surface models [0.03%]
响应面模型中交互作用指标存在的条件分析
Erhan Yumuk,Clara Ionescu
Erhan Yumuk
Response-surface models (RSMs) are widely used to characterize the combined effects of two agents and to classify their interaction as additivity, synergy, or antagonism. In this context, an interaction index is frequently used as a quantit...
Model informed assessment of QT prolongation during drug development: a five-year retrospective analysis of EMA scientific advices [0.03%]
基于模型的心脏安全评估在药物研发中的应用——EMA五年回顾分析
Happy Phanio Djokoto,Jean-Michel Dogné,Flora T Musuamba
Happy Phanio Djokoto
Regulatory evaluation of QT interval prolongation remains central to cardiac safety assessment in drug development. Since the 2015 revision of the ICH E14 Q&A, concentration-QT (C-QT) modelling has been formally recognized as an acceptable ...
Andrew P Woodward
Andrew P Woodward
Antimicrobial therapy is informed by quantitative models of drug disposition and action. These models utilize experimental and observational evidence, subject to uncertainties, to support drug selection and dosage regimen optimization, and ...
A physics-informed neural network approach for estimating population-level pharmacokinetic parameters from aggregated concentration data [0.03%]
基于聚合浓度数据估计人群水平药动学参数的物理信息神经网络方法
Periklis Tsiros,Vasileios Minadakis,Haralambos Sarimveis
Periklis Tsiros
The pharmacokinetic literature is rich in aggregated concentration data that contain valuable information, yet tools to extract this information remain limited. This work introduces distributional physics-informed neural networks (D-PINNs),...
A mechanistic pharmacokinetic-pharmacodynamic model for degrader-antibody conjugates [0.03%]
降解剂-抗体偶联物的机制药代动力学-药物动力学模型
Martha P Balthasar,Derek W Bartlett
Martha P Balthasar
Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency [0.03%]
基于模拟的P-糖蛋白表达活性关系的评估显示药物和系统的依赖性
Daan W van Valkengoed,Vivi Rottschäfer,Elizabeth C M de Lange
Daan W van Valkengoed
In vitro-in vivo extrapolation (IVIVE) of P-glycoprotein (P-gp) transporter activity bears two important assumptions: (1) P-gp expression (i.e., concentration) is linearly related to P-gp activity; and (2) this relation is drug independent....
Correction to: Catalyzing change in MID3 through globalization, education, and innovation [0.03%]
Correction to: 全球化、教育与创新对MID3变化的催化作用
Douglas W Chung,Sihem Ait-Oudhia
Douglas W Chung