A hybrid PKPD agent-based model of the tumour immune interaction: effects of anti-cancer combination therapy [0.03%]
Van Thuy Truong,Grant Lythe,Paolo Vicini et al.
Van Thuy Truong et al.
We have developed a three dimensional hybrid multiscale agent-based ODE PDE model including tumour immune interaction, cell cycle phases, oxygen and drug diffusion dynamics, the pharmacodynamics of chemotherapy, targeted therapies, immunoth...
Early exposure-response modeling of an interferon-beta monoclonal antibody (dazukibart) in adults with dermatomyositis [0.03%]
John P Prybylski,Jing &#x;Daisy&#x; Zhu,Christopher Banfield et al.
John P Prybylski et al.
Dermatomyositis (DM) is a rare and debilitating inflammatory disease associated with muscle weakness and skin manifestations. As with all rare diseases, clinical trials in DM are challenging due to the small number of patients available for...
Utility of a physiologically-based pharmacokinetic model for investigating time-dependent variability in the fetal-to-maternal plasma concentration ratio of digoxin [0.03%]
Kanoko Okuba,Kenji Ikeda
Kanoko Okuba
The purpose of this study was to elucidate the mechanisms underlying the wide variability in fetal-to-maternal (F/M) concentration ratios of digoxin by comprehensively characterizing maternal and fetal pharmacokinetics using a physiological...
Modeling, Simulation, and Extrapolation to Optimize Pediatric Development Plan: Sarilumab Polyarticular-Course juvenile arthritis Application [0.03%]
Christine Xu,Mei Zhang,Ying Liu et al.
Christine Xu et al.
Polyarticular-course juvenile idiopathic arthritis (pcJIA) is a chronic condition that manifests before the age of 16 years, with pathology similar to that of adult rheumatoid arthritis (RA). Sarilumab is an interleukin-6 receptor inhibitor...
Assessing the impact of bacterial heterogeneity on bacteriophage population dynamics [0.03%]
评估细菌异质性对噬菌体种群动态的影响
Massinissa Beldjenna,Jérémie Guedj,J G Coen van Hasselt et al.
Massinissa Beldjenna et al.
Bacteriophages follow complex replication dynamics in codependence with their host cells. The corresponding dynamics are usually described with three key parameters: the adsorption rate , the burst size and the latent period . Single-cell ...
On the existence conditions of interaction indices in response surface models [0.03%]
响应面模型中交互作用指标存在的条件分析
Erhan Yumuk,Clara Ionescu
Erhan Yumuk
Response-surface models (RSMs) are widely used to characterize the combined effects of two agents and to classify their interaction as additivity, synergy, or antagonism. In this context, an interaction index is frequently used as a quantit...
Model informed assessment of QT prolongation during drug development: a five-year retrospective analysis of EMA scientific advices [0.03%]
基于模型的心脏安全评估在药物研发中的应用——EMA五年回顾分析
Happy Phanio Djokoto,Jean-Michel Dogné,Flora T Musuamba
Happy Phanio Djokoto
Regulatory evaluation of QT interval prolongation remains central to cardiac safety assessment in drug development. Since the 2015 revision of the ICH E14 Q&A, concentration-QT (C-QT) modelling has been formally recognized as an acceptable ...
Andrew P Woodward
Andrew P Woodward
Antimicrobial therapy is informed by quantitative models of drug disposition and action. These models utilize experimental and observational evidence, subject to uncertainties, to support drug selection and dosage regimen optimization, and ...
A physics-informed neural network approach for estimating population-level pharmacokinetic parameters from aggregated concentration data [0.03%]
基于聚合浓度数据估计人群水平药动学参数的物理信息神经网络方法
Periklis Tsiros,Vasileios Minadakis,Haralambos Sarimveis
Periklis Tsiros
The pharmacokinetic literature is rich in aggregated concentration data that contain valuable information, yet tools to extract this information remain limited. This work introduces distributional physics-informed neural networks (D-PINNs),...