Protein Kinase C Blockers Do Not Reverse the Cardioprotective Effect of Probiotic Strains in Rats with a Systemic Inflammatory Response [0.03%]
蛋白激酶C阻滞剂不能逆转系统性炎性反应大鼠的益生菌株心脏保护作用
Yu Yu Borshchev,S M Minasyan,I Yu Burovenko et al.
Yu Yu Borshchev et al.
The hypothesis that protein kinase C (PKC) participates in the signaling stage of the cardioprotective response to the administration of probiotics was tested in experiments on male Wistar rats using a model of systemic inflammatory respons...
DNA Vaccine Encoding the prM-E Polyprotein of the Tick-Borne Encephalitis Virus [0.03%]
编码蜱传脑炎病毒prM-E聚蛋白的DNA疫苗
E V Tigeeva,V A Yakovlev,M B Borgoyakova et al.
E V Tigeeva et al.
We evaluated immunogenicity of the experimental DNA-vaccine construct pVAX-prM-E encoding the polyprotein prM-E of the tick-borne encephalitis virus (strain Sofjin). It was shown that pVAX-prM-E administered to mice using a needle-free jet ...
Spastic Hypertonia Following Middle Cerebral Artery Occlusion in Rats: Assessment of Behavioral, Electrophysiological, and Morphological Parameters in Dynamics [0.03%]
大鼠大脑中动脉闭塞后痉挛性肌张力增高：动态评估行为、电生理和形态学参数
Tian-Yi Sun,Ling-Hui Ma,Liang-Xiao Ma et al.
Tian-Yi Sun et al.
Gradual changes in muscle resistance after ischemic stroke offer precious insights into the time-course development of spastic hypertonia, but quantitative data about temporal changes in muscle tension are insufficient, particularly about c...
Sleeve Gastrectomy Effect on Structural and Functional Myocardium Characteristics and Trpc3, Trpc6, Tgfb1, and Atp2a2 Gene Expression in Rats with Post-Infarction Heart Failure [0.03%]
袖状胃切除术后胃手术对心梗后心力衰竭大鼠结构性和功能性心肌特征及Trpc3、Trpc6、Tgfb1和Atp2a2基因表达的影响
V I Pan,O V Kornyushin,T A Lelyavina et al.
V I Pan et al.
A positive effect of sleeve gastrectomy on the structural and functional characteristics of the left ventricular myocardium in rats with normal body weight and post-infarction CHF was demonstrated. Sleeve gastrectomy attenuated the upregula...
Expression of Genes Responsible for Wound Healing in Dermal Fibroblasts under Hypoxia [0.03%]
缺氧对皮肤成纤维细胞创面修复相关基因表达的影响
E V Solovieva,K A Darienko,A A Wainson et al.
E V Solovieva et al.
During wound healing, which is accompanied by hypoxia at the initial stages, the gene expression profile in fibroblasts shifts to facilitate the synthesis of proteins necessary for tissue restoration. In this study, we describe the influenc...
Involvement of Cortical Associative Areas in Acquisition and Retrieval of Delayed and Traced Conditioned Fear in Mice [0.03%]
小鼠延迟条件性恐惧和追踪条件性恐惧获得及提取与皮层联系区的关系
K A Toropova,O I Ivashkina,O S Rogozhnikova et al.
K A Toropova et al.
Associative learning is a universal mechanism for acquiring new experience; it can be modeled in animals using fear conditioning (FC). Based on the temporal relationship between the conditioned and unconditioned stimuli, two paradigms of FC...
The "Double-Hit" Model in Experimental Parkinsonism: Effects of Combined Exposure to Lactacystin and LPS [0.03%]
乳酸半胱氨酸和内毒素联合暴露引起帕金森病的“Double-hit”模型及其作用机制研究
A V Stavrovskaya,A A Gerasimov,D N Voronkov et al.
A V Stavrovskaya et al.
The present study aimed to investigate a "double-hit" model of Parkinson's disease, implying intranigral administration of lactacystin and intraperitoneal injection of LPS. The model group rats exhibited significant deterioration in several...
Does Microfluidic Sperm Sorting Affect Embryo Ploidy in Human In Vitro Fertilization? [0.03%]
微流控精子分选技术对体外受精胚胎染色体倍性的的影响？
N P Makarova,A A Seliverstova,I S Kichko et al.
N P Makarova et al.
The genetic status of embryos obtained during in vitro fertilization (IVF) programs using spermatozoa selected by microfluidic sorting was evaluated. Genetic testing was conducted on 127 embryos in the main group and 194 in the control grou...
Isolation and Characterization of a New Bacteriophage: Host Range Assessment and Prospects of Use in the Identification of Moraxella spp [0.03%]
一株新型噬菌体的分离与鉴定及其宿主范围和在莫拉克斯菌属细菌鉴别中的应用前景评估
N V Pimenov,Z S Mohammed,N A Buzmakova et al.
N V Pimenov et al.
Bacteria of the genus Moraxella are significant pathogens in both human clinical practice and veterinary medicine. A novel bacteriophage, designated vB_MboM_ZALNahr, was isolated from environmental sources (wastewater from the Moscow Region...
Dose-Dependent Angiogenic Effects of Intravenous Nicotinamide Riboside in Mice with a Lewis Lung Carcinoma Model [0.03%]
尼可坦醇剂量依赖性地促进小鼠Lewis肺癌模型中新生血管的生成
E Y Podyacheva,N Y Semenova,I A Makhnin et al.
E Y Podyacheva et al.
We studied the dose-dependent effects of the NAD+ precursor nicotinamide riboside (NR) on tumor angiogenesis in C57BL/6N mice with Lewis lung carcinoma. The pharmacological agent was repeatedly administered intravenously at doses of 300 and...