Immunogenicity of the Stabilized Env Trimer HIV-1 CRF63_02A6 Produced in Protein and DNA Vaccine Formats [0.03%]
稳定型Env三聚体HIV-1 CRF63_02A6蛋白和DNA疫苗的免疫原性研究
N B Rudometova,A P Rudometov,A A Fando et al.
N B Rudometova et al.
Stabilized trimers of the HIV-1 Env surface glycoprotein are considered as one of the main directions in the design of an HIV-1 vaccine, both individually and in prime-boost immunization strategies. The article presents the results of a stu...
Hypermethylated Long Non-Coding RNA Genes KCNK15-AS1, MAGI2-AS3, and SSTR5-AS1 in Ovarian Cancer and Their Diagnostic Potential [0.03%]
长链非编码RNA基因KCNK15-AS1、MAGI2-AS3和SSTR5-AS1在卵巢癌中的高甲基化及诊断潜力
S S Lukina,A M Burdenyy,E A Filippova et al.
S S Lukina et al.
We identified new diagnostic markers for ovarian cancer based on the analysis of aberrant methylation in a group of long non-coding RNA (lncRNA) genes. Using quantitative methyl-specific PCR with the nonparametric Mann-Whitney test, a signi...
Evaluation of Transferrin Level in Iron Supplementation after Partial Hepatectomy [0.03%]
术后铁补充治疗中转铁蛋白水平的评估
Weiwei Fang,Chang Pang,Xiying Li
Weiwei Fang
Here we studied the effect of partial hepatectomy in patients with liver cancer (n = 48) on the level of serum iron and whether it can be corrected with iron supplementation therapy (IST; daily for 9 days). To identify whether the rapid dec...
Clinical and Morphological Features of gPALB2-Associated Breast Cancer in the Russian Population [0.03%]
俄罗斯人群gPALB2相关乳腺癌的临床和形态学特征
V A Fedko,E V Artamonova,A M Stroganova et al.
V A Fedko et al.
The analysis included 3,800 cases of breast cancer. Next-generation sequencing (NGS) of DNA extracted from peripheral blood leukocytes revealed mutations in the gPALB2 gene in 39 (1.03%) patients. The most frequent mutations were c.509_510d...
Protective Effect of Conditioned Medium from Bone Marrow Mesenchymal Stem Cells on the Cornea of Rabbits with Impaired Blink Reflex [0.03%]
骨髓间充质干细胞条件培养基对兔瞬目反射受损角膜的保护作用
V V Tiulina,S V Lavrushkina,A I Dovgii et al.
V V Tiulina et al.
We studied the efficiency of a conditioned medium containing the secretome of bone marrow mesenchymal stem cells in preventing corneal damage in rabbits using an experimental model of dry eye syndrome caused by impaired blinking reflex. The...
Hematological Parameters in Colitis-Associated Colorectal Cancer in Animals with Different Resistance to Hypoxia [0.03%]
不同耐缺氧性动物中炎症相关结直肠癌的血液学参数研究
D Sh Dzhalilova,M V Silina,I S Tsvetkov et al.
D Sh Dzhalilova et al.
Hematological parameters were evaluated, proinflammatory immune response indices lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) were calculated, and iron was detected in tumor tissues by Perls' staining of histo...
Class III Antiarrhythmic Drug Cavutilide Does Not Increase the Susceptibility of the Ventricles to Phenylephrine-Induced Tachyarrhythmias Due to the Direct Dependence of the Effect on the Frequency of Myocardial Activation [0.03%]
III类抗心律失常药物Cavutilide不会通过直接依赖于心肌激动频率的作用机制增加心室对肾上腺素诱发的快速性心律失常的敏感性
V S Kuzmin,A A Abramov,Yu V Egorov et al.
V S Kuzmin et al.
Class III antiarrhythmic drugs used for the treatment of supraventricular tachyarrhythmias can induce polymorphic ventricular tachycardia known as "torsade de pointes" (TdP). This adverse side effect of antiarrhythmic drugs is more pronounc...
Generation of a HEK293 Cell Line with Stable Expression of Molecular Tools for Thermogenetic Activation [0.03%]
稳定表达用于热遗传学激活分子工具的HEK293细胞系的构建
V S Ovechkina,P S Suvorova,S K Andrianova et al.
V S Ovechkina et al.
In modern biotechnological and biomedical research, it is often necessary to activate mammalian cells to obtain a specific response, such as changes in membrane potential or generation of action potential in excitable cells and tissues. The...
"Homeostatic" Cytokines Enhance the Expression of PD-1, Tim-3, and Their Ligands on Myeloid Cells [0.03%]
“体内平衡式”细胞因子可增强髓系细胞上PD-1、Tim-3及其配体的表达
O Yu Leplina,M A Tikhonova,E V Batorov et al.
O Yu Leplina et al.
We studied the expression of checkpoint molecules in monocyte subsets and monocytic myeloid-derived suppressor cells (M-MS) and the effect of homeostatic cytokines (IL-2, IL-7, IL-15) on the expression of PD-1/PD-L1 and Tim-3/Galectin-9 by ...
Transformed and Tumor Cells Spontaneously Produce DNA-Containing Extracellular Structures In Vitro [0.03%]
转化和肿瘤细胞在体外自发产生含有DNA的胞外结构
A N Kazimirskii,J M Salmasi,G V Poryadin et al.
A N Kazimirskii et al.
The parameters of DNA-containing extracellular structures formed by immortalized fibroblasts and HCT116 adenocarcinoma cells during cultivation were studied. Fluorescence microscopy with SYBR Green dye was used to visualize DNA-containing e...