Fate of Transplanted Allogeneic Mesenchymal Stromal Cells in the Rat Spinal Cord under Normal Conditions and during the Acute Phase of Spinal Cord Contusion Injury [0.03%]
正常条件及脊髓挫伤急性期移植的同种异体间充质基质细胞的命运考察
M O Shkap,D A Chudakova,I L Gubsky et al.
M O Shkap et al.
We studied the distribution and survival of mesenchymal stem cells (MSCs) transplanted within a fibrin hydrogel into the spinal cord of immunocompetent rats without spinal cord injury (SCI) and with contusion SCI within the first hours afte...
Effectiveness of Argon-Oxygen Mixture for Maintaining the Viability of Cultured Cells under the Influence of Membrane-Damaging Factors [0.03%]
氩氧混合气对膜损伤因素作用下培养细胞活性的影响研究
N V Borovkova,A K Shabanov,M S Makarov et al.
N V Borovkova et al.
The protective properties of argon-oxygen mixture were studied in the culture of M-22 human fibroblasts, piglet thymus cells, and rat brain cells. To induce damage to cell membranes, 200 μM H2O2 and 500 μM acetic acid were used. The cells...
Optimization of Mitotic Index Quantification Using the Amnis ImageStream Imaging Flow Cytometer [0.03%]
基于Amnis ImageStream imaging flow cytometer的有丝分裂指数定量优化方法研究
I V Kholodenko,K N Yarygin,Y S Kim
I V Kholodenko
The mitotic index is a critical indicator of the proliferative activity of cell populations and is widely used in oncology and stem cell research. One of the most promising methods for its assessment is imaging flow cytometry implemented on...
Modifications of the Secretome of Mesenchymal Stromal Cells under Conditions of Stress-Induced Aging [0.03%]
应激诱导衰老条件下间充质基质细胞分泌组的改变
D N Kashirina,A Yu Ratushny,D K Matveeva et al.
D N Kashirina et al.
It is known that the senescence-associated secretory phenotype (SASP) can promote senescence of surrounding normal cells. However, SASP signaling during senescence of mesenchymal stromal cells (MSCs) has not yet been fully studied. We deter...
Role of Coiled-Coil Domain-Containing Protein 86 in Tumorigenesis of Nasopharyngeal Carcinoma [0.03%]
鼻咽癌发病中CCDC86的作用机制研究
Xubo Chen,Zhi Wang,Bing Liao et al.
Xubo Chen et al.
Coiled-coil domain-containing protein 86 (CCDC86) expression is correlated with the occurrence of lymphoma. However, the expression of CCDC86 in solid tumors such as nasopharyngeal carcinoma (NPC) and the effects of CCDC86 on tumorigenesis ...
Effect of Melatonin on the Expression of α2- and β1-Adrenergic Receptors in the Liver of db/db Mice. Immunohistochemical Characteristics [0.03%]
褪黑素对db/db小鼠肝脏α2-和β1-肾上腺素受体表达的影响及免疫组化特征分析
S V Michurina,S I Kolesnikov,D V Vasendin et al.
S V Michurina et al.
Markers of α2- and β1-adrenergic receptors (AR) were detected immunohistochemically in the liver of db/db mice with obesity and type 2 diabetes mellitus before and after melatonin treatment. Melatonin (1 mg/kg in 200 μl distilled water) ...
Effect of Deoxyglucose on Cultured Glial Cells of the Rat Cerebral Cortex under Conditions of LPS Stimulation [0.03%]
2-脱氧葡萄糖对脂多糖刺激下培养的大鼠大脑皮层神经胶质细胞的影响
N K Isaev,E E Genrikhs,E V Stelmashook
N K Isaev
It was shown that blocking of glycolysis by 2-deoxy-D-glucose (DG) inhibits LPS-induced NO production in glial cell cultures and reduces the mitochondrial membrane potential. Lactate partially prevented the decrease in the mitochondrial mem...
Wilms Tumor 1 Associated Protein (WTAP) Inhibits Inflammation Provoked by Mycobacterium tuberculosis in Microglial BV-2 Cells and Promotes Differentiation of Neural Stem/Progenitor Cells into Neurons by Elevating Expression of HMGN3 Protein Resulted from Modulation of m6A Metilation of Its RNA [0.03%]
Wilms瘤1相关蛋白(WTAP)通过上调HMGN3蛋白表达促进神经干细胞向神经元分化并抑制小胶质细胞BV-2中由结核杆菌引发的炎症反应(涉及m6A甲基化修饰机制)
Mingming Ma,Xingwu Zou,Jing Zhao et al.
Mingming Ma et al.
Tuberculous meningitis (TBM) is the most prevalent and severe manifestation of tuberculosis in CNS. The mechanisms of neurological injury caused by TBM are not well understood. Our study showed that overexpression of WTAP (Wilms tumor 1 ass...
Adaptation of Mycobacterium tuberculosis to a New Aroylhydrazone Derivative In Vitro and Possible Role of Rv3755c Gene [0.03%]
结核分枝杆菌对新型芳香烯甲腙衍生物的体外适应性及其潜在机制研究
I V Mokrousov,V Angelova,S Dimitrov et al.
I V Mokrousov et al.
We evaluated the response of Mycobacterium tuberculosis to exposure to a new aroylhydrazone derivative using the in vitro mutagenesis followed by genomic analysis of a resistant variant. The compound N'-[(E)-(5-methoxy-1H-indol-3-yl)methyli...
Genetic Loci of TNFα Level Regulation in Blood Serum of Women with Uterine Fibroids [0.03%]
子宫肌瘤女性血液中TNFα水平调控的遗传位点研究
V I Konenkov,V F Prokofiev,A V Shevchenko et al.
V I Konenkov et al.
The TNFα content in the blood serum of 109 patients with uterine fibroids was studied. Cytokine concentrations ranged from 4.65 to 25.88 pg/ml regardless of the clinical parameters of the disease, but were associated with complex genotypes...