Neurodegenerative Disorders of Alzheimer, Parkinsonism, Amyotrophic Lateral Sclerosis and Multiple Sclerosis: An Early Diagnostic Approach for Precision Treatment [0.03%]
阿尔茨海默病，帕金森综合症，运动神经元病和多发性硬化等神经变性疾病：精准治疗的早期诊断方法
Nishit Pathak,Sunil Kumar Vimal,Ishi Tandon et al.
Nishit Pathak et al.
Neurodegenerative diseases (NDs) are characterised by progressive dysfunction of synapses, neurons, glial cells and their networks. Neurodegenerative diseases can be classified according to primary clinical features (e.g., dementia, parkins...
Novel IBA57 mutations in two chinese patients and literature review of multiple mitochondrial dysfunction syndrome [0.03%]
两名中国患者的IBA57新突变及多源线粒体功能障碍综合征文献回顾
Feixia Zhan,Xiaoli Liu,Ruilong Ni et al.
Feixia Zhan et al.
Multiple mitochondrial dysfunction syndrome (MMDS) refers to a class of mitochondrial diseases caused by nuclear gene mutations, which usually begins in early infancy and is classically characterized by markedly impaired neurological develo...
Circular RNA circLIFR regulates the proliferation, migration, invasion and apoptosis of human vascular smooth muscle cells via the miR-1299/KDR axis [0.03%]
环状RNA circLIFR通过miR-1299/KDR轴调控人血管平滑肌细胞的增殖、迁移、侵袭和凋亡
Hui Zhang,Bin Zhang,Chen Chen et al.
Hui Zhang et al.
Dysfunction of vascular smooth muscle cells (VSMCs) plays a critical role in the development of intracranial aneurysm (IA). Here, we explored the detailed role and mechanism of circular RNA (circRNA) LIF receptor subunit alpha (circLIFR, ci...
Akanksha Singh,Namita Agrawal
Akanksha Singh
Huntington's disease (HD) is a progressively debilitating neurodegenerative disease exhibiting autosomal-dominant inheritance. It is caused by an unstable expansion in the CAG repeat tract of HD gene, which transforms the disease-specific H...
Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotransmission pathway [0.03%]
补充马油树的饮食可保护因斯科波胺诱导的小鼠空间记忆缺陷而造成的皮层海马神经元变性：氧化炎症和胆碱能神经传递通路的作用
Samuel Adetunji Onasanwo,Vanessa O Adamaigbo,Olusegun G Adebayo et al.
Samuel Adetunji Onasanwo et al.
The therapeutic and pharmacological management of Alzheimer's disease (AD) is generally considered a major concern in ethnomedicine. Moreover, plant-based foods containing flavonoids were previously reported to show neuroprotective effects ...
The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease [0.03%]
碳酸酐酶III和自噬在二型糖尿病并发心脑血管疾病中的作用
Xiao-Ming Zhang,Ying-Hong Tao,Xiu-Ling Zhou et al.
Xiao-Ming Zhang et al.
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases among the elderly people. The T2DM increases the risk of cardio-cerebrovascular disease (CCD), and the main pathological change of the CCD is atherosclerosis (AS). M...
Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner [0.03%]
长链非编码RNA SNHG7通过上调FGF9以miR-134-5p依赖性方式缓解氧糖剥夺诱导的神经元细胞损伤
Wei Sun,Lu Sun,Xiaopeng Sun et al.
Wei Sun et al.
Long non-coding RNA small nucleolar RNA host gene 7 (SNHG7) was reported to regulate the pathogenesis of ischemic stroke. The study aimed to disclose SNHG7 role in oxygen and glucose deprivation (OGD)-induced Neuro-2a (N2a) cell disorders. ...
Impaired mitochondrial functions and energy metabolism in MPTP-induced Parkinson's disease: comparison of mice strains and dose regimens [0.03%]
MPTP诱导的帕金森病中受损的线粒体功能和能量代谢：小鼠品系和剂量方案的比较
Anjana Pathania,Priyanka Garg,Rajat Sandhir
Anjana Pathania
Heterogenous diseases such as Parkinson's disease (PD) needs an efficient animal model to enhance understanding of the underlying mechanisms and to develop therapeutics. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin, has...
Downregulation of lncRNA MEG3 is involved in Parkinson's disease [0.03%]
长链非编码 RNA MEG3 的下调表达与帕金森病有关
Hui Huang,Suyue Zheng,Mingwei Lu
Hui Huang
Background: Long non-coding RNA (lncRNA) MEG3 regulates human cancers, while its role in Parkinson's disease (PD) is unknown. The present study explored the involvement of MEG3 in PD. ...
MicroRNA-32-5p attenuates cerebral ischemia/reperfusion injuries by modulating the phosphatase and tensin homologous protein [0.03%]
微小RNA-32-5p通过调节同源磷酸酶和张力蛋白以减轻脑缺血/再灌注损伤
Yao Wang,Weiyi Pan,Yulong Wang et al.
Yao Wang et al.
Non-coding RNAs have recently attracted much attention with the potential in the treatment of cerebral ischemia/reperfusion (I/R) injuries. In this study, we investigated the role of miR-32-5p in cerebral I/R injuries by using oxygen-glucos...