Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis [0.03%]
circ_0057583通过调节miR-204-5p/NR4A1轴促进脑微血管内皮细胞损伤
Xiaoyu Wang,Lili Liu,Lei Zhang et al.
Xiaoyu Wang et al.
Lipopolysaccharide (LPS) can induce vascular endothelial injury. Circular RNAs (circRNAs) have been verified to regulate different cellular processes in various diseases. This study intended to explore the potential role and mechanism of ci...
Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men [0.03%]
中等强度连续训练和大强度间歇训练提高超重的中年男性认知能力及BDNF水平
Neumir Sales de Lima,Ricardo Augusto Leoni De Sousa,Fabiano Trigueiro Amorim et al.
Neumir Sales de Lima et al.
The prevalence of overweight and obesity is increasing worldwide, which has been associated with poor cognitive outcomes. Participating in regular physical exercise may also improve cognition, and levels of brain-derived neurotrophic factor...
Randomized Controlled Trial
Metabolic brain disease. 2022 Feb;37(2):463-471. DOI:10.1007/s11011-021-00859-5 2022
A novel probiotic strain exerts therapeutic effects on mouse model of multiple sclerosis by altering the expression of inflammasome and IDO genes and modulation of T helper cytokine profile [0.03%]
一种新的益生菌株通过改变炎症小体和IDO基因的表达以及调节T辅助细胞因子谱对多发性硬化症的小鼠模型产生治疗作用
Saba Sadeghirashed,Fatemeh Kazemi,Saba Taheri et al.
Saba Sadeghirashed et al.
Multiple sclerosis is an inflammatory demyelinating disease that commences to neuronal cell destruction. Recently, a promising evidence of synergic effects of combined supplementation with vitamin D and probiotics in modulating the gut micr...
Quercetin mitigates scopolamine-induced memory dysfunction: impact on oxidative stress and cholinergic mechanisms [0.03%]
黄酮可以缓解由东莨菪碱诱导的记忆功能障碍：对氧化应激和胆碱能机制的影响
Juliet N Olayinka,Anthony Eduviere,Olusegun Adeoluwa et al.
Juliet N Olayinka et al.
Despite the promising neuroprotective activities of quercetin (QT), its' effect on cholinergic neurotransmission needs further elucidation. In this study, we explored the impact of QT on oxidative stress and cholinergic neurotransmission wi...
Selective in vitro anticancer effect of blueberry extract (Vaccinium virgatum) against C6 rat glioma: exploring their redox status [0.03%]
蓝莓提取物(Vaccinium virgatum)对大鼠胶质瘤C6的选择性体外抗癌作用：探索其氧化还原状态
Larissa Menezes da Silveira,Nathalia Stark Pedra,Natália Pontes Bona et al.
Larissa Menezes da Silveira et al.
The aim of this study was to investigate the anticancer potential of blueberry extract (Vaccinium virgatum) against a C6 rat glioma lineage. Cultures of the C6 cells were exposed to blueberry extract at concentrations of 50 to 600 µg/mL fo...
Circular RNA circ_0070441 regulates MPP+-triggered neurotoxic effect in SH-SY5Y cells via miR-626/IRS2 axis [0.03%]
环状RNA circ_0070441通过miR-626/IRS2轴调节SH-SY5Y细胞中MPP+触发的神经毒性效应
Xuqing Cao,Jiangtao Guo,Hideki Mochizuki et al.
Xuqing Cao et al.
Circular RNAs (circRNAs) was suggested to play crucial regulatory roles in various human diseases, including Parkinson's disease (PD). This research aimed to investigate the function and potential mechanism of circ_0070441 in PD. MPP+ (1-me...
Possible involvement of NO-sGC-cGMP signaling in the antidepressant like effect of pyridoxine in mice [0.03%]
维生素B6的抗抑郁作用可能与NO-sGC-cGMP信号通路有关
Sushma Maratha,Vijay Sharma,Vaibhav Walia
Sushma Maratha
The present study was designed to determine the antidepressant like effect of pyridoxine in mice. Pyridoxine (12.5, 25 and 50 mg/kg, i.p.) was administered to the mice and depression related behavioral and neurochemical alterations were det...
Adult human neurogenesis: early studies clarify recent controversies and go further [0.03%]
成人神经发生：早期研究阐明近期争议并更进一步
Adriano Barreto Nogueira,Hillary Sayuri Ramires Hoshino,Natalia Camargo Ortega et al.
Adriano Barreto Nogueira et al.
Evidence on adult mammalian neurogenesis and scarce studies with human brains led to the idea that adult human neurogenesis occurs in the subgranular zone (SGZ) of the dentate gyrus and in the subventricular zone (SVZ). However, findings pu...
Therapeutic potential of probiotics - Lactobacillus plantarum UBLP40 and Bacillus clausii UBBC07 on thioacetamide-induced acute hepatic encephalopathy in rats [0.03%]
益生菌的治疗潜力 - 大鼠硫乙酰胺所致急性肝性脑病中UBLP40植物乳杆菌和UBBC07枯草芽孢杆菌的作用
Lalita Shahgond,Chirag Patel,Khushboo Thakur et al.
Lalita Shahgond et al.
Purpose: Hepatic encephalopathy (HE) or hepatic coma is a demanding, not utterly understood complication of acute and chronic liver dysfunction and portosystemic shunting. In HE, hyperammonemia and inflammatory responses ...
A novel protein truncating mutation in L2HGDH causes L-2-hydroxyglutaric aciduria in a consanguineous Pakistani family [0.03%]
L2HGDH基因中的一种新型蛋白质截短突变导致了一个近亲结婚的巴基斯坦家庭中出现L-2-羟基戊二酸尿症
Muhammad Muzammal,Muhammad Zeeshan Ali,Beatrice Brugger et al.
Muhammad Muzammal et al.
Background: L-2-hydroxyglutaric aciduria (L2HGA) is a rare neurometabolic disorder that occurs due to accumulation of L-2-hydroxyglutaric acid in the cerebrospinal fluid (CSF), plasma and urine. The clinical manifestation...