Functional SLC6A3 polymorphisms differentially affect autism spectrum disorder severity: a study on Indian subjects [0.03%]
功能性SLC6A3基因多态性对孤独症谱系障碍的严重程度影响不同：针对印度人群的研究
Sharmistha Saha,Mahasweta Chatterjee,Sayanti Shom et al.
Sharmistha Saha et al.
Imbalance in dopamine (DA) signaling is proposed to play a potential role in the etiology of Autism spectrum disorder (ASD) since, as a neuromodulator, DA regulates executive function, motor activity, social peering, attention as well as pe...
Bacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish [0.03%]
Bacopa monnieri减轻谷氨酸诱导的斑马鱼疼痛和脑线粒体毒性
Mahima Sharma,Pankaj Gupta,Debapriya Garabadu
Mahima Sharma
Bacopa monnieri L. (BM; Family: Scrophulariaceae), commonly known as Brahmi, is traditionally used as a nootropic agent. BM also exhibits significant analgesic activity in experimental models of pain. However, the effect of Bacopa monnieri ...
Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson's disease [0.03%]
利拉鲁肽通过AMPK/NF-κB通路在帕金森病小鼠模型中对抗炎症的神经保护作用
Bing Cao,Yanqiu Zhang,Jinhu Chen et al.
Bing Cao et al.
Parkinson's disease (PD) is a neurodegenerative disease with increasing incidence in aged populations, second only to Alzheimer's disease. Increasing evidence has shown that inflammation plays an important role in the occurrence and develop...
Association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene polymorphism with obesity and lipid metabolism in children and adolescents with autism spectrum disorder [0.03%]
HMG-CoA还原基因多态性与孤独症儿童肥胖和脂质代谢的关系
Si Jin Kwon,Kyung-Won Hong,Silvia Choi et al.
Si Jin Kwon et al.
The prevalence of obesity among children and adolescents with autism spectrum disorder (ASD) is higher than that among typically developing children and adolescents. However, very few studies have explored the genetic factors associated wit...
cAMP/PKA-CREB-BDNF signaling pathway in hippocampus of rats subjected to chemically-induced phenylketonuria [0.03%]
化学诱导的苯丙酮尿症大鼠海马中cAMP/PKA-CREB-BDNF信号通路的研究
Cigdem Cicek,Emine Eren-Koçak,Pelin Telkoparan-Akillilar et al.
Cigdem Cicek et al.
Phenylketonuria (PKU) is an inborn error disease in phenylalanine metabolism resulting from defects in the stages of converting phenylalanine to tyrosine. Although the pathophysiology of PKU is not elucidated yet, the toxic effect of phenyl...
MiR-1224 downregulation inhibits OGD/R-induced hippocampal neuron apoptosis through targeting Ku protein [0.03%]
miR-1224下调通过靶向Ku蛋白抑制OGD/R诱导的海马神经元凋亡
Juan Wan,Tao Xiao
Juan Wan
Ischemic cerebrovascular disease is the main cause of disability due to stroke. This study aimed to investigate the function of miR-1224 in OGD/R-induced hippocampal neuron apoptosis, as well as the regulatory mechanism of miR-1224 in ische...
Convergent molecular mechanisms underlying cognitive impairment in mucopolysaccharidosis type II [0.03%]
黏多糖贮积症II型认知障碍的趋同分子机制
Thiago Corrêa,Fabiano Poswar,Cíntia B Santos-Rebouças
Thiago Corrêa
Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder caused by pathogenic variants in the iduronate-2-sulfatase gene (IDS), responsible for the degradation of glycosaminoglycans (GAGs) heparan and dermatan sulfate. IDS enz...
KIAA0101 knockdown inhibits glioma progression and glycolysis by inactivating the PI3K/AKT/mTOR pathway [0.03%]
KIAA0101敲低通过失活PI3K/AKT/mTOR通路抑制胶质瘤进展和糖酵解
Kai Wang,Jinxiao Li,Botao Zhou
Kai Wang
KIAA0101, a proliferating cell nuclear antigen (PCNA)-associated factor, is reported to be overexpressed and identified as an oncogene in several human malignancies. The purpose of this study is to determine the function and possible mechan...
Chronic and progressive dopaminergic neuronal death in substantia nigra associates with a decrease in serum levels of glucose and free fatty acids, the role of interlokin-1 beta [0.03%]
慢性进行性黑质多巴胺能神经元死亡与血清葡萄糖和游离脂肪酸水平降低的关系，白介素-1β的作用
Ali Sarbazi-Golezari,Hashem Haghdoost-Yazdi
Ali Sarbazi-Golezari
Human studies indicate that Parkinson's disease (PD) associates with disruption in metabolism of glucose and free fatty acids (FFA). Studies have shown that interlukin-1beta (IL-1β) causes hypoglycemia through insulin- independent mechanis...
Association between genetic variants and risk of obsessive-compulsive disorder [0.03%]
基因变异与强迫症风险的关联
Mohammad Taheri,Elham Badrlou,Bashdar Mahmud Hussen et al.
Mohammad Taheri et al.
Obsessive-compulsive disorder (OCD) is a complex multi-gene disorder. In the current study, we genotyped six single nucleotide polymorphisms (SNPs) within MOCOS, NINJ2 and AKT1 genes in a cohort of Iranian patients with this disorder and he...