Experimental validation of Vitex negundo leaves hydroalcoholic extract for neuroprotection in haloperidol induced parkinson's disease in rat [0.03%]
实验验证假荆芥叶水醇提取物在氯丙嗪诱导的大鼠帕金森病中的神经保护作用
Aishwarya Vannur,Prakash R Biradar,Vishal Patil
Aishwarya Vannur
Parkinsonism is a neurodegenerative disease, mainly imbalance in dopamine and acetylcholine neurotransimitter in mid brain, which manifestation of dysfunctions of extrapyramidal like akinesia, tremor, rigidity and catalepsy etc., even cogni...
Promising protein biomarkers in the early diagnosis of Alzheimer's disease [0.03%]
阿尔茨海默病早期诊断的蛋白质生物标志物
Lalit Sharma,Aditi Sharma,Deepak Kumar et al.
Lalit Sharma et al.
Alzheimer's disease (AD) is an insidious, multifactorial disease that involves the devastation of neurons leading to cognitive impairments. Alzheimer's have compounded pathologies of diverse nature, including proteins as one important facto...
Plasma phosphorylated-tau181 levels reflect white matter microstructural changes across Alzheimer's disease progression [0.03%]
血浆磷酸化tau181水平反映了阿尔茨海默病进展过程中的白质微结构变化
Fardin Nabizadeh,Mahsa Pourhamzeh,Saghar Khani et al.
Fardin Nabizadeh et al.
Alzheimer's Disease (AD) is characterized by cognitive impairments that hinder daily activities and lead to personal and behavioral problems. Plasma hyperphosphorylated tau protein at threonine 181 (p-tau181) has recently emerged as a new s...
Sesamol prevents mitochondrial impairment and pro-inflammatory alterations in the human neuroblastoma SH-SY5Y cells: role for Nrf2 [0.03%]
sesameol通过激活Nrf2防止神经母细胞瘤SH-SY5Y细胞的线粒体功能障碍和促炎改变的作用机制研究
Sônia Mendes da Silva Navarro,Fhelipe Jolner Souza de Almeida,Matheus Dargesso Luckachaki et al.
Sônia Mendes da Silva Navarro et al.
Mitochondria are a primary source and a target of reactive oxygen species (ROS). Increased mitochondrial production of ROS is associated with bioenergetics decline, cell death, and inflammation. Here we investigated whether a pretreatment (...
Disorders of Tetrahydrobiopterin Metabolism: Experience from South India [0.03%]
四氢生物蝶呤代谢紊乱：来自印度南部的诊治经验
Somdattaa Ray,Hansashree Padmanabha,Vykuntaraju K Gowda et al.
Somdattaa Ray et al.
Background: Disorders of tetrahydrobiopterin metabolism represent a rare group of inherited neurotransmitter disorders that manifests mainly in infancy or childhood with developmental delay, neuroregression, epilepsy, mov...
Effect of Solanum vegetables on memory index, redox status, and expressions of critical neural genes in Drosophila melanogaster model of memory impairment [0.03%]
富含茄科蔬菜饮食对果蝇记忆力损伤模型中记忆指数、氧化还原状态及关键神经基因表达的影响
Opeyemi B Ogunsuyi,Olawande C Olagoke,Blessing A Afolabi et al.
Opeyemi B Ogunsuyi et al.
African eggplant (Solanum macrocarpon L) (AE) and Black Nightshade (Solanum nigrum L) (BN) leaves are green leafy vegetables with nutritional and ethnobotanical values. We have previously characterized the vegetables via HPLC/LC-MS to revea...
Mustafa Nazıroğlu
Mustafa Nazıroğlu
The overload cytosolic free Ca2+ (cCa2+) influx-mediated excessive generation of oxidative stress in the pathophysiological conditions induces neuronal and cellular injury via the activation of cation channels. TRPM2 and TRPV4 channels are ...
Apelin-13 protects against memory impairment and neuronal loss, Induced by Scopolamine in male rats [0.03%]
阿普利宁通过减少烟碱乙酰胆碱受体β4亚型的表达改善雌激素缺乏大鼠认知功能下降
Sara Gazmeh,Maryam Azhir,Leila Elyasi et al.
Sara Gazmeh et al.
The present study aimed to evaluate the effects of Apelin-13 on scopolamine-induced memory impairment in rats. Forty male rats were divided into five groups of eight. The control group received no intervention; the scopolamine group underwe...
Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase [0.03%]
Sanguisorba minor对山梗菜碱致大鼠记忆缺失的影响：氧化应激和乙酰胆碱酯酶的介导作用
Zeinab Hosseini,Fatemeh Mansouritorghabeh,Faezeh Sadat Hosseini Kakhki et al.
Zeinab Hosseini et al.
Sanguisorba minor (S. minor) has neuroprotective and antioxidant activities. However, its potential benefits in ameliorating learning and memory functions have been explored in no studies up to now. So, in the current study, rats were treat...
Impaired ion homeostasis as a possible associate factor in mucopolysaccharidosis pathogenesis: transcriptomic, cellular and animal studies [0.03%]
/mp_/离子稳态受损可能参与黏多糖贮积症的发生发展：转录组、细胞及动物研究
Lidia Gaffke,Zuzanna Szczudło,Magdalena Podlacha et al.
Lidia Gaffke et al.
Mucopolysaccharidoses (MPS) are a group of diseases caused by mutations resulting in deficiencies of lysosomal enzymes which lead to the accumulation of partially undegraded glycosaminoglycans (GAG). This phenomenon causes severe and chroni...