Remote ischemic preconditioning protects against cerebral ischemia injury in rats by upregulating miR-204-5p and activating the PINK1/Parkin signaling pathway [0.03%]
远程缺血预处理通过上调miR-204-5p和激活PINK1/Parkin信号通路保护大鼠脑缺血损伤
Yiming Jiao,Jinlan Wang,Yanjie Jia et al.
Yiming Jiao et al.
Remote ischemic preconditioning (RiPC) is the process where preconditioning ischemia protects the organs against the subsequent index ischemia. RiPC is a protective method for brain damage. This study is to explore the effect and mechanism ...
LncRNA NEAT1 ameliorate ischemic stroke via promoting Mfn2 expression through binding to Nova and activates Sirt3 [0.03%]
长链非编码RNA NEAT1通过与Nova结合促进Mfn2表达并激活Sirt3来改善缺血性卒中
Zhi-Wen Zhou,Xiang Ren,Li-Jun Zheng et al.
Zhi-Wen Zhou et al.
Background: Recent studies revealed that long non-coding RNAs (lncRNAs) have significant roles in regulating the pathogenesis of ischemia stroke, and oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cell apoptosis...
Analysis of expression profiles and bioinformatics suggests that plasma exosomal circular RNAs may be involved in ischemic stroke in the Chinese Han population [0.03%]
表达谱分析和生物信息学表明血浆外泌体环状RNA可能参与了汉族人群的缺血性卒中
Bingyi Xu,Xianli Huang,Yan Yan et al.
Bingyi Xu et al.
Circular RNAs (circRNAs) have been confirmed to be associated with ischemic stroke(IS), but the involvement of exosomal circRNAs in plasma still needs to be extensively discussed. Therefore, we aimed to investigate the expression profile of...
Epigenetic regulation and autophagy modulation debilitates insulin resistance associated Alzheimer's disease condition in rats [0.03%]
表观遗传调控和自噬修饰削弱相关阿尔茨海默病小鼠的胰岛素抵抗状况
Violina Kakoty,Sarathlal K C,Sunil Kumar Dubey et al.
Violina Kakoty et al.
Insulin resistance (IR) and accumulation of amyloid beta (Aβ) oligomers are potential causative factor for Alzheimer's Disease (AD). Simultaneously, enhanced clearance level of these oligomers through autophagy activation bring novel insig...
Evaluation of Styrylbenzene analog- FSB and its affinity to bind parenchymal plaques and tangles in patients of Alzheimer's disease [0.03%]
茋衍生物FSB的评估及其与阿尔茨海默病患者脑皮层淀粉样斑块和神经纤维缠结的亲和力研究
Sharay E Setti,Nikita Das,James Raymick et al.
Sharay E Setti et al.
Although several histochemical markers for senile plaques (SP) and neurofibrillary tangles (NFTs) have been synthesized since the discovery of plaques in Alzheimer's disease (AD), only a handful of these markers stain both lesions in the hu...
Airway inflammation induces anxiety-like behavior through neuroinflammatory, neurochemical, and neurometabolic changes in an allergic asthma model [0.03%]
气道炎症通过神经炎症、神经化学和神经代谢的变化在过敏性哮喘模型中诱发类似焦虑的行为
Géssica Luana Antunes,Josiane Silva Silveira,Carolina Luft et al.
Géssica Luana Antunes et al.
Allergic asthma is characterized by chronic airway inflammation and is constantly associated with anxiety disorder. Recent studies showed bidirectional interaction between the brain and the lung tissue. However, where and how the brain is a...
Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition [0.03%]
circHECTD1敲低抑制缺氧/葡萄糖剥夺再灌注诱导的内皮-间质转化
Guo-Hua He,Zhen Wang,Wei Xu et al.
Guo-Hua He et al.
Ischemic stroke (IS) has become a cerebrovascular disease which seriously threatens the elderly people. It has been reported that circRNAs participate in multiple diseases, including IS. However, the role of circHECTD1 in IS remains largely...
Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease [0.03%]
银杏内酯B通过促进自噬降解使NLRP3炎性小体失活以改善阿尔茨海默病学习记忆障碍
Li Shao,Chen Dong,Deqin Geng et al.
Li Shao et al.
The NLR family, pyrin domain containing 3 (NLRP3) inflammasome drives the progression of Alzheimer's disease (AD). Ginkgolide B (GB) is a potential anti-inflammatory compound that controls neuro-inflammation. The aim of this study was to ev...
Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis [0.03%]
牛磺酸补充通过保护神经元和减少星形胶质细胞增生改善宫内生长受限幼鼠海马代谢
Qiong Fang,Jing Liu,Lang Chen et al.
Qiong Fang et al.
Taurine as an essential amino acid in the brain could play an important role in protecting the fetal brain of intrauterine growth restriction (IUGR). The hippocampus with IUGR showed neural metabolic disorder and structure changed that affe...
Effect of curcumin nanoparticles on streptozotocin-induced male Wistar rat model of Alzheimer's disease [0.03%]
姜黄素纳米颗粒对链佐星诱导的雄性Wistar阿尔茨海默病模型的影响
Neveen A Noor,Eman N Hosny,Yasser A Khadrawy et al.
Neveen A Noor et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disease that afflicts millions of people all over the world. Intracerebroventricular (ICV) injection of a sub-diabetogenic dose of streptozotocin (STZ) was established as an experi...